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We investigated whether PLWH who underwent autologous hematopoietic stem cell transplantation (ASCT) for lymphomas experienced significant morbidity over the past thirty years following HIV infection. We conducted a retrospective follow\u2010up study of 49 PLWH over a 10\u2010year period following ASCT. We collected survival data, examined the occurrence of long\u2010term events, assessed CD4\u2009+\u2009T\u2010cell immune recovery, and analysed the correlation between immune recovery and the events experienced by these patients. The data confirmed the significant long\u2010term effectiveness of ASCT, with an overall survival rate of 78% at 10 years post\u2010ASCT. Opportunistic infections, which occurred soon after ASCT and were associated with lower CD4\u2009+\u2009T\u2010cell counts, were successfully managed. However, lymphoma relapse, secondary malignancies, cardiovascular disease, and bone disease, which developed years after ASCT, were major causes of morbidity and mortality in this population. Our findings highlight the need for the development and validation of specific tests to predict risk and guide effective interventions for metabolic diseases, secondary malignancies, and lymphoma relapses in PLWH treated with ASCT for lymphoma.<\/jats:p>","DOI":"10.1002\/jmv.70165","type":"journal-article","created":{"date-parts":[[2025,1,15]],"date-time":"2025-01-15T04:12:16Z","timestamp":1736914336000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Long\u2010Term Clinical Outcomes After Autologous Hematopoietic Stem Cell Transplantation in 49 Individuals Living With HIV (PLWH) and Affected by High\u2010Risk or Relapsed Lymphoma: A European Experience of Continued Relevance for PLWH"],"prefix":"10.1002","volume":"97","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3451-075X","authenticated-orcid":false,"given":"Ernesto","family":"Zanet","sequence":"first","affiliation":[{"name":"Department of Medical Oncology 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