{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,15]],"date-time":"2026-09-15T20:05:43Z","timestamp":1789502743986,"version":"build-2803163510"},"reference-count":26,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2025,1,21]],"date-time":"2025-01-21T00:00:00Z","timestamp":1737417600000},"content-version":"vor","delay-in-days":20,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal of Medical Virology"],"published-print":{"date-parts":[[2025,1]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>Human papillomavirus (HPV) infections rank as the most prevalent sexually transmitted infections globally. The Brazilian Ministry of Health recommends the topical use of 70%\u201390% trichloroacetic acid (TAA) for treating condyloma acuminata, yet this method suffers from a high recurrence rate of 36% and requires roughly six applications. Topical photodynamic therapy (PDT) has shown effectiveness in targeting subclinical lesions, but it also necessitates multiple sessions for complete lesion clearance. This randomized clinical trial evaluates the efficacy of 80% TAA monotherapy against a combined approach of ultrasonic scalpel excision followed by a single PDT session (US\u2009+\u2009PDT). The US\u2009+\u2009PDT group required fewer treatment sessions, exhibited superior cosmetic outcomes, and reported zero lesion recurrence during an 18\u2010month follow\u2010up, in contrast to the TAA group's recurrence rate of 33.3%. Notwithstanding, patient\u2010reported pain during PDT application emerged as a significant barrier, affecting treatment adherence and completion rates. Innovating new PDT protocols could potentially address this challenge, enhancing patient compliance and therapeutic success.<\/jats:p>","DOI":"10.1002\/jmv.70177","type":"journal-article","created":{"date-parts":[[2025,1,21]],"date-time":"2025-01-21T07:15:46Z","timestamp":1737443746000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Comparative Efficacy of Ultrasonic Scalpel Surgery With Photodynamic Therapy Versus Trichloroacetic Acid Application in Treating HPV\u2010Related Condyloma Acuminata: A Randomized Clinical Trial"],"prefix":"10.1002","volume":"97","author":[{"given":"Valter Fausto","family":"dos Santos","sequence":"first","affiliation":[{"name":"Interunit Graduate Program in Bioengineering University of Sao Paulo Sao Paulo Brazil"},{"name":"Department of Medicine Federal University of S\u00e3o Carlos S\u00e3o Carlos Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ian Carlos","family":"de Barros","sequence":"additional","affiliation":[{"name":"Department of Medicine Federal University of S\u00e3o Carlos S\u00e3o Carlos Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vera Lucia Damasceno","family":"Tomazella","sequence":"additional","affiliation":[{"name":"Department of Statistics Federal University of S\u00e3o Carlos S\u00e3o Carlos Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adriane Caroline Teixeira","family":"Portela","sequence":"additional","affiliation":[{"name":"Department of Statistics Federal University of S\u00e3o Carlos S\u00e3o Carlos Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Semira Silva","family":"de Arruda","sequence":"additional","affiliation":[{"name":"Interunit Graduate Program in Bioengineering University of Sao Paulo Sao Paulo Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hilde Harb","family":"Buzza","sequence":"additional","affiliation":[{"name":"Institute of Physics Pontificia Universidad Catolica de Chile Santiago Chile"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Natalia Mayumi","family":"Inada","sequence":"additional","affiliation":[{"name":"Sao Carlos Institute of Physics University of Sao Paulo Sao Paulo Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vanderlei Salvador","family":"Bagnato","sequence":"additional","affiliation":[{"name":"Sao Carlos Institute of Physics University of Sao Paulo Sao Paulo Brazil"},{"name":"Department of Biomedical Engineering Texas A&amp;M University College Station Texas USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5197-9162","authenticated-orcid":false,"given":"Mirian Denise","family":"Stringasci","sequence":"additional","affiliation":[{"name":"Sao Carlos Institute of Physics University of Sao Paulo Sao Paulo Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,1,21]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.297.8.813"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.virusres.2016.12.017"},{"key":"e_1_2_10_4_1","volume-title":"Condyloma Acuminata","author":"Pennycook K. 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