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This article explores the potential of amphiphilic non\u2010cationic porphyrin\u2010fullerene dyads as HIV\u20101 inhibitors under both PDT (light\u2010treated) and non\u2010PDT (dark) conditions. The amphiphilic P\u2010F dyads,\n                    <jats:bold>PB<\/jats:bold>\n                    <jats:sub>\n                      <jats:bold>3<\/jats:bold>\n                    <\/jats:sub>\n                    <jats:bold>C<\/jats:bold>\n                    <jats:sub>\n                      <jats:bold>60<\/jats:bold>\n                    <\/jats:sub>\n                    and\n                    <jats:bold>PB<\/jats:bold>\n                    <jats:sub>\n                      <jats:bold>3<\/jats:bold>\n                    <\/jats:sub>\n                    <jats:bold>C<\/jats:bold>\n                    <jats:sub>\n                      <jats:bold>70<\/jats:bold>\n                    <\/jats:sub>\n                    , demonstrated enhanced efficacy in inhibiting the entry and production of HIV\u20101 (subtypes B and C). Under light\u2010harvested conditions, the dyads exhibited potent inhibitory effects (EC\n                    <jats:sub>50<\/jats:sub>\n                    for\n                    <jats:bold>PB<\/jats:bold>\n                    <jats:sub>\n                      <jats:bold>3<\/jats:bold>\n                    <\/jats:sub>\n                    <jats:bold>C<\/jats:bold>\n                    <jats:sub>\n                      <jats:bold>60<\/jats:bold>\n                    <\/jats:sub>\n                    and\n                    <jats:bold>PB<\/jats:bold>\n                    <jats:sub>\n                      <jats:bold>3<\/jats:bold>\n                    <\/jats:sub>\n                    <jats:bold>C<\/jats:bold>\n                    <jats:sub>\n                      <jats:bold>70<\/jats:bold>\n                    <\/jats:sub>\n                    \u2009&lt;\u200910\u2009nM) and also maintained significant inhibition under non\u2010PDT conditions (EC\n                    <jats:sub>50<\/jats:sub>\n                    for\n                    <jats:bold>PB<\/jats:bold>\n                    <jats:sub>\n                      <jats:bold>3<\/jats:bold>\n                    <\/jats:sub>\n                    <jats:bold>C<\/jats:bold>\n                    <jats:sub>\n                      <jats:bold>60<\/jats:bold>\n                    <\/jats:sub>\n                    \u2009=\u20091.43\u2009\u03bcM and\n                    <jats:bold>PB<\/jats:bold>\n                    <jats:sub>\n                      <jats:bold>3<\/jats:bold>\n                    <\/jats:sub>\n                    <jats:bold>C<\/jats:bold>\n                    <jats:sub>\n                      <jats:bold>70<\/jats:bold>\n                    <\/jats:sub>\n                    \u2009=\u20091.50\u2009\u03bcM), while displaying notably reduced toxicity compared to their water\u2010soluble porphyrin precursor. The P\u2010F dyads exhibited substantial efficacy in neutralizing the T20\u2010resistant strain 9491, both at the entry and postentry phases, thereby addressing the challenge of drug resistance.\n                  <\/jats:p>","DOI":"10.1002\/jmv.70181","type":"journal-article","created":{"date-parts":[[2025,1,27]],"date-time":"2025-01-27T08:56:55Z","timestamp":1737968215000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Fullerene (C\n                    <sub>60<\/sub>\n                    &amp; C\n                    <sub>70<\/sub>\n                    )\u2010\n                    <i>Meso<\/i>\n                    \u2010Tris\u20104\u2010Carboxyphenyl Porphyrin Dyads Inhibit Entry of Wild\u2010Type and Drug\u2010Resistant HIV\u20101 Clades B and C"],"prefix":"10.1002","volume":"97","author":[{"given":"Debdulal","family":"Sharma","sequence":"first","affiliation":[{"name":"Department of Chemistry Assam University Silchar India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Madhu","family":"Rai","sequence":"additional","affiliation":[{"name":"Faculty of Life Sciences and Biotechnology South Asian University New Delhi India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aradhana","family":"Singh","sequence":"additional","affiliation":[{"name":"Faculty of Life Sciences and Biotechnology South Asian University New Delhi India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4243-9623","authenticated-orcid":false,"given":"Ritu","family":"Gaur","sequence":"additional","affiliation":[{"name":"Faculty of Life Sciences and Biotechnology South Asian University New Delhi India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7512-8664","authenticated-orcid":false,"given":"Devashish","family":"Sengupta","sequence":"additional","affiliation":[{"name":"Department of Chemistry Assam University Silchar India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,1,27]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1080\/17460441.2023.2246872"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.3390\/microorganisms11010221"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.2147\/PPA.S445164"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.34172\/jrhs.2023.115"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12981-023-00572-6"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2023.1294966"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.46.12.3917-3925.2002"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1039\/b503535j"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bmcl.2020.127675"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.inorgchem.2c00975"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1002\/chem.202101098"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bmcl.2022.128699"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejmech.2019.04.051"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.1002\/cbic.200300773"},{"issue":"1","key":"e_1_2_10_16_1","first-page":"47","article-title":"Inhibition of Human Immunodeficiency Virus\u20101 Reverse Transcriptase by Heme and Synthetic Heme Analogs","volume":"108","author":"Staudinger R.","year":"1996","journal-title":"Proceedings of the Association of American Physicians"},{"key":"e_1_2_10_17_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.bioconjchem.1c00123"},{"key":"e_1_2_10_18_1","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2012.00129"},{"key":"e_1_2_10_19_1","doi-asserted-by":"publisher","DOI":"10.3390\/molecules25194368"},{"key":"e_1_2_10_20_1","doi-asserted-by":"publisher","DOI":"10.1177\/095632029200300505"},{"key":"e_1_2_10_21_1","doi-asserted-by":"publisher","DOI":"10.1021\/jp066494p"},{"key":"e_1_2_10_22_1","doi-asserted-by":"publisher","DOI":"10.1021\/jm00096a020"},{"key":"e_1_2_10_23_1","volume-title":"The Synthesis of Boronated Porphyrins as Inhibitors of HIV\u20101 Protease","author":"Schaeck J. 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