{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,11]],"date-time":"2026-04-11T05:33:15Z","timestamp":1775885595881,"version":"3.50.1"},"reference-count":45,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2025,1,27]],"date-time":"2025-01-27T00:00:00Z","timestamp":1737936000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal of Medical Virology"],"published-print":{"date-parts":[[2025,2]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:sec><jats:label\/><jats:p>Patients with diabetes are at increased risk of HBV infection; however, the effects of HBV infection and anti\u2010HBV therapy on the management of type 1 diabetes (T1D), type 2 diabetes (T2D), and latent autoimmune diabetes in adults (LADA) remain unclear.<\/jats:p><\/jats:sec><jats:sec><jats:label\/><jats:p>From 2016 to 2023, we recruited a multicenter cohort of 355 HBV\u2010infected inpatients, including 136 with T1D, 140 with T2D, and 79 with LADA. The control group included 525 HBV\u2010uninfected inpatients, comparing 171 with T1D, 204 with T2D and 150 with LADA. We employed propensity\u2010score matching between cases and controls to minimize confounding effects. Hemoglobin A1c (HbA1c) was monitored at baseline and at months 1, 2, and 3.<\/jats:p><\/jats:sec><jats:sec><jats:label\/><jats:p>At baseline, median HbA1c was significantly higher in HBV\u2010infected patients compared to their HBV\u2010uninfected controls: T1D (10.4% vs<jats:italic>.<\/jats:italic> 7.5%, <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.01), T2D (9.6% <jats:italic>vs.<\/jats:italic> 8.6%, <jats:italic>p<\/jats:italic>\u2009=\u20090.01), and LADA (9.4% vs<jats:italic>.<\/jats:italic> 8.4%, <jats:italic>p<\/jats:italic>\u2009=\u20090.03). Baseline HbA1c levels were significantly lower in HBV\u2010treated patients compared to those HBV\u2010untreated patients, regardless of whether they were on antidiabetic therapy (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.05). A 90\u2010day follow\u2010up consistently indicated lower HbA1c levels at baseline, as well as at months 1, 2, and 3 among HBV\u2010treated patients with T1D, T2D, or LADA. Both univariate and multivariate analyses identified HBV therapy (OR\u2009=\u20090.44, <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001) and antidiabetic treatment(OR\u2009=\u20090.51, <jats:italic>p<\/jats:italic>\u2009=\u20090.031) as protective factors for glycemic control in HBV\u2010infected patients with diabetes.<\/jats:p><\/jats:sec><jats:sec><jats:label\/><jats:p>Poor glycemic control is found in HBV\u2010infected patients with diabetes, but the intervention of anti\u2010HBV therapy and antidiabetic treatment contributes to improved glycemic control in HBV\u2010infected patients with T1D, T2D, or LADA.<\/jats:p><\/jats:sec>","DOI":"10.1002\/jmv.70185","type":"journal-article","created":{"date-parts":[[2025,1,27]],"date-time":"2025-01-27T14:05:51Z","timestamp":1737986751000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["The Effect of HBV Therapy on Glycemic Control in HBV\u2010Infected Patients With Diabetes: A 90\u2010day Multicenter Study"],"prefix":"10.1002","volume":"97","author":[{"given":"Qi","family":"Liu","sequence":"first","affiliation":[{"name":"Department of Metabolism and Endocrinology, The Second Xiangya Hospital National Clinical Research Center for Metabolic Diseases, Key Laboratory of Diabetes Immunology, Ministry of Education Changsha China"},{"name":"Xiangya School of Public Health, Central South University Changsha China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jie","family":"Huang","sequence":"additional","affiliation":[{"name":"Xiangya School of Public Health, Central South University Changsha China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jingyi","family":"Hu","sequence":"additional","affiliation":[{"name":"Department of Metabolism and Endocrinology, The Second Xiangya Hospital National Clinical Research Center for Metabolic Diseases, Key Laboratory of Diabetes Immunology, Ministry of Education Changsha 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