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Using VALENCIA classification, the study identified different community state types (CSTs) of vaginal microbiota, with CST IV subtypes (<jats:italic>Staphylococcus<\/jats:italic> dominated) showing high diversity and increased pathogenic bacteria. Results showed a higher microbial diversity in women with CIN compared to HPV\u2010negative women, with specific microbial profiles like <jats:italic>Enterococcus faecalis<\/jats:italic> and <jats:italic>Staphylococcus aureus<\/jats:italic> correlating with HPV infection severity. LEfSe and STAMP analyses revealed that particular bacterial species, such as <jats:italic>Fannyhessea vaginae<\/jats:italic> and <jats:italic>Sneathia vaginalis<\/jats:italic>, could serve as biomarkers for HPV and CIN status. Furthermore, <jats:italic>Streptococcus<\/jats:italic> and <jats:italic>Staphylococcus<\/jats:italic> were associated with HPV genotypes \u03b17 and \u03b19, respectively. These findings highlight how the composition of vaginal microbiota may influence HPV persistence and CIN progression, emphasizing the need for further research into microbial dysbiosis as a potential target for cervical cancer prevention and management.<\/jats:p>","DOI":"10.1002\/jmv.70190","type":"journal-article","created":{"date-parts":[[2025,1,27]],"date-time":"2025-01-27T14:08:26Z","timestamp":1737986906000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Exploring the Interplay Between Cervicovaginal Microbiome, HPV Infection, and Cervical Intraepithelial Neoplasia in Taiwanese Women"],"prefix":"10.1002","volume":"97","author":[{"ORCID":"https:\/\/orcid.org\/0009-0006-6939-8389","authenticated-orcid":false,"given":"Chung\u2010Yao","family":"Yang","sequence":"first","affiliation":[{"name":"Hygeia Touch Inc. 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