{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,16]],"date-time":"2026-02-16T15:49:21Z","timestamp":1771256961073,"version":"3.50.1"},"reference-count":23,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2025,2,1]],"date-time":"2025-02-01T00:00:00Z","timestamp":1738368000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal of Medical Virology"],"published-print":{"date-parts":[[2025,2]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:p>Kaposi's sarcoma\u2010associated herpesvirus (KSHV) is the etiologic agent of several human cancers, including primary effusion lymphoma (PEL), usually seen in immunocompromised patients while lack of effective therapeutic options. Interleukin\u20101 (IL\u20101) family is a major mediator for inflammatory responses and has functional role in both innate and adaptive immunity. We previously showed high activation of multiple IL\u20101 signaling molecules during KSHV latent and lytic stages, as well as in clinical samples from patients with KSHV\u2010related malignancies. In the current study, we identified RP\u201054745, a potential antirheumatic compound as IL\u20101 inhibitor, effectively repressed KSHV\u2009+\u2009PEL cell growth through inducing tumor cell apoptosis. By using an established PEL xenograft model, we found that RP\u201054745 treatment suppressed tumor expansion in mice. Also, RP\u201054745 treatment significantly reduced hyperinflammation in tumor microenvironment including myeloid cells and neutrophils infiltration, as well as blocking IL\u20101 signaling molecules expression in vivo. In addition, our transcriptome analysis revealed novel cellular genes and mechanisms for anticancer activities of RP\u201054745. Taken together, our data indicate targeting IL\u20101 production and signaling may represent promising therapeutic strategies against these virus\u2010associated diseases.<\/jats:p>","DOI":"10.1002\/jmv.70200","type":"journal-article","created":{"date-parts":[[2025,2,1]],"date-time":"2025-02-01T13:40:17Z","timestamp":1738417217000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Identification of RP\u201054745, an IL\u20101 Inhibitor Displaying Anticancer Activities for KSHV\u2010Related Primary Effusion Lymphoma"],"prefix":"10.1002","volume":"97","author":[{"given":"Lu","family":"Dai","sequence":"first","affiliation":[{"name":"Department of Pathology, Winthrop P. Rockefeller Cancer Institute University of Arkansas for Medical Sciences Little Rock Arkansas USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Amrita","family":"Choudhary","sequence":"additional","affiliation":[{"name":"Little Rock Central High School Little Rock Arkansas USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jiaojiao","family":"Fan","sequence":"additional","affiliation":[{"name":"Department of Pathology, Winthrop P. Rockefeller Cancer Institute University of Arkansas for Medical Sciences Little Rock Arkansas USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lu","family":"Huang","sequence":"additional","affiliation":[{"name":"Department of Microbiology and Immunology University of Arkansas for Medical Sciences Little Rock Arkansas USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhen","family":"Lin","sequence":"additional","affiliation":[{"name":"Department of Pathology &amp; Laboratory Medicine Tulane University Health Sciences Center, Tulane Cancer Center New Orleans Louisiana USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9905-1275","authenticated-orcid":false,"given":"Zhiqiang","family":"Qin","sequence":"additional","affiliation":[{"name":"Department of Pathology, Winthrop P. Rockefeller Cancer Institute University of Arkansas for Medical Sciences Little Rock Arkansas USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2025,2]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.chom.2014.02.011"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.coviro.2022.101270"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.37349\/etat.2024.00242"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-3-031-59815-9_36"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.3389\/fcimb.2022.1049624"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.3389\/fcimb.2020.587929"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.03282-12"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1128\/mBio.00917-17"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2015-07-658823"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.ppat.1000742"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.3390\/cancers11060759"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF01991239"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF01991240"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.2147\/JIR.S488340"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0018487"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-3-319-27472-0_1"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13045-018-0645-x"},{"key":"e_1_2_9_19_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood.2024024144"},{"key":"e_1_2_9_20_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2019-01-893339"},{"key":"e_1_2_9_21_1","doi-asserted-by":"publisher","DOI":"10.1128\/mBio.02843-20"},{"key":"e_1_2_9_22_1","doi-asserted-by":"publisher","DOI":"10.1128\/mbio.03011-23"},{"key":"e_1_2_9_23_1","doi-asserted-by":"publisher","DOI":"10.1186\/1479-5876-11-173"},{"key":"e_1_2_9_24_1","doi-asserted-by":"publisher","DOI":"10.3390\/antiox11081509"}],"container-title":["Journal of Medical Virology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/jmv.70200","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,12]],"date-time":"2025-04-12T07:20:40Z","timestamp":1744442440000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/jmv.70200"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,2]]},"references-count":23,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2025,2]]}},"alternative-id":["10.1002\/jmv.70200"],"URL":"https:\/\/doi.org\/10.1002\/jmv.70200","archive":["Portico"],"relation":{},"ISSN":["0146-6615","1096-9071"],"issn-type":[{"value":"0146-6615","type":"print"},{"value":"1096-9071","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,2]]},"assertion":[{"value":"2024-11-22","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-01-18","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-02-01","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e70200"}}