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To precisely evaluate the health status of convalescent patients with COVID\u201019, we analyzed symptom and proteome data of 442 plasma samples from healthy controls, hospitalized patients, and convalescent patients 6 or 12 months after SARS\u2010CoV\u20102 infection. Symptoms analysis revealed distinct relationships in convalescent patients. Results of plasma protein expression levels showed that C1QA, C1QB, C2, CFH, CFHR1, and F10, which regulate the complement system and coagulation, remained highly expressed even at the 12\u2010month follow\u2010up compared with their levels in healthy individuals. By combining symptom and proteome data, 442 plasma samples were categorized into three subtypes: S1 (metabolism\u2010healthy), S2 (COVID\u201019 retention), and S3 (long COVID). We speculated that convalescent patients reporting hair loss could have a better health status than those experiencing headaches and dyspnea. Compared to other convalescent patients, those reporting sleep disorders, appetite decrease, and muscle weakness may need more attention because they were classified into the S2 subtype, which had the most samples from hospitalized patients with COVID\u201019. Subtyping convalescent patients with COVID\u201019 may enable personalized treatments tailored to individual needs. This study provides valuable plasma proteomic datasets for further studies associated with long COVID.<\/jats:p>","DOI":"10.1002\/jmv.70203","type":"journal-article","created":{"date-parts":[[2025,4,10]],"date-time":"2025-04-10T08:55:51Z","timestamp":1744275351000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Proteomic Analysis of 442 Clinical Plasma Samples From Individuals With Symptom Records Revealed Subtypes of Convalescent Patients Who Had COVID\u201019"],"prefix":"10.1002","volume":"97","author":[{"given":"Jiangfeng","family":"Liu","sequence":"first","affiliation":[{"name":"Haihe Laboratory of Cell Ecosystem Tianjin China"},{"name":"State Key Laboratory of Common Mechanism Research for Major Diseases, Department of Biochemistry and Molecular Biology School of Basic Medicine, Institute of Basic Medical Sciences Chinese Academy of Medical Sciences, Peking Union Medical College Beijing 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