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This retrospective analysis included all elderly individuals with COVID\u201019 admitted to the Second Medical Center of PLA General Hospital from December 2022 to January 2023. The follow\u2010up period ended on March 30, 2023. During this time, epidemiological, demographic, laboratory, and outcome data were analyzed descriptively. Proteomic sequencing was performed on super\u2010elderly patients who died from COVID\u201019 at different stages of the disease. A total of 352 elderly COVID\u201019 patients, with a mean age of 89.84\u2009\u00b1\u20098.54 years, were included in this study. During a median follow\u2010up period of 98 days, 79 patients died. Deceased patients were older and more likely to have cardiovascular and cerebrovascular diseases, with a lower prevalence of lipid\u2010lowering therapy. The number of deaths in the acute and post\u2010acute phases were 34 and 45, respectively. Proteomics data suggest that the immune systems of patients who died in the acute phase underwent a more rapid and severe onslaught. Patients in the post\u2010acute phase showed higher levels of viral genome replication and a more robust immune response. However, the over\u2010activation of the immune system led to systemic organ dysfunction. Effective management of comorbidities may improve the prognosis of COVID\u201019 in super\u2010elderly patients. The continuous replication of the SARS\u2010CoV\u20102 virus and its subsequent impact on the immune system are critical determinants of survival time in this demographic.<\/jats:p>","DOI":"10.1002\/jmv.70207","type":"journal-article","created":{"date-parts":[[2025,2,9]],"date-time":"2025-02-09T12:39:42Z","timestamp":1739104782000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Clinical and Multiorgan Proteomics Characteristics of the Diverse Fatal Phase in Super Elderly Patients With SARS\u2010CoV\u20102 Infection: A Descriptive Study"],"prefix":"10.1002","volume":"97","author":[{"given":"Shuxia","family":"Wang","sequence":"first","affiliation":[{"name":"Department of Geriatrics, The Second Medical Center &amp; National Clinical Research Center for Geriatric Diseases Chinese PLA General Hospital Beijing 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