{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,12]],"date-time":"2026-06-12T15:11:17Z","timestamp":1781277077117,"version":"3.54.1"},"reference-count":42,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2025,2,13]],"date-time":"2025-02-13T00:00:00Z","timestamp":1739404800000},"content-version":"vor","delay-in-days":12,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal of Medical Virology"],"published-print":{"date-parts":[[2025,2]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:p>Influenza A virus infection can cause acute respiratory distress syndrome (ARDS), and to date, viral pneumonia has been the main cause of ARDS. Bone marrow mesenchymal stem cells have shown promise for treating lung injury caused by avian influenza virus infection. At present, studies of the use of other stem cell types to treat human influenza virus\u2010mediated lung damage are sparse. We assessed the use of umbilical cord mesenchymal stem cells (UC\u2010MSCs) to treat damage from serious H1N1 influenza virus infections in cell and animal\u2010based experiments. Maximum viral titers, inflammatory factor expression levels, differential expression of alveolar cell\u2010related proteins, animal weight and survival rate, lung histopathology, and other indicators were evaluated. Compared with the control group, in cellular experiments, UC\u2010MSCs could effectively inhibit H1N1 influenza viral replication and repair damaged host cells. In animal experiments, UC\u2010MSCs reduced expression of pro\u2010inflammatory cytokines, reduced entry of inflammatory cells into the lungs, alleviated lung inflammation, significantly reduced the extent of lung injury in mice, and improved lung histopathology, improving overall survival. A positive role of umbilical cord\u2010derived mesenchymal stem cells in treating lung injury caused by H1N1 influenza virus infection that is worthy of clinical promotion has been demonstrated.<\/jats:p>","DOI":"10.1002\/jmv.70214","type":"journal-article","created":{"date-parts":[[2025,2,14]],"date-time":"2025-02-14T07:55:11Z","timestamp":1739519711000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Umbilical Cord Mesenchymal Stem Cells Could Reduce Lung Damage Caused by H1N1 Influenza Virus Infection"],"prefix":"10.1002","volume":"97","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7188-2256","authenticated-orcid":false,"given":"Chun Yan","family":"Guo","sequence":"first","affiliation":[{"name":"Shaanxi Provincial Key Laboratory of Infection and Immune Diseases Shaanxi Provincial People's Hospital Xi'an Shaanxi China"},{"name":"Shaanxi Province Research Center of Cell Immunological Engineering and Technology Shaanxi Provincial People's Hospital Xi'an Shaanxi China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yi","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Hematology Shaanxi Provincial People's Hospital Xi'an Shaanxi China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qing","family":"Feng","sequence":"additional","affiliation":[{"name":"Shaanxi Provincial Key Laboratory of Infection and Immune Diseases Shaanxi Provincial People's Hospital Xi'an Shaanxi China"},{"name":"Shaanxi Province Research Center of Cell Immunological Engineering and Technology Shaanxi Provincial People's Hospital Xi'an Shaanxi China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Li Jun","family":"Sun","sequence":"additional","affiliation":[{"name":"Shaanxi Provincial Key Laboratory of Infection and Immune Diseases Shaanxi Provincial People's Hospital Xi'an Shaanxi China"},{"name":"Shaanxi Province Research Center of Cell Immunological Engineering and Technology Shaanxi Provincial People's Hospital Xi'an Shaanxi China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yang Meng","family":"Feng","sequence":"additional","affiliation":[{"name":"Shaanxi Provincial Key Laboratory of Infection and Immune Diseases Shaanxi Provincial People's Hospital Xi'an Shaanxi China"},{"name":"Shaanxi Province Research Center of Cell Immunological Engineering and Technology Shaanxi Provincial People's Hospital Xi'an Shaanxi China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yi Han","family":"Dong","sequence":"additional","affiliation":[{"name":"School of Medicine Yan'an University Yan'an Shaanxi China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cui Xiang","family":"Xu","sequence":"additional","affiliation":[{"name":"Shaanxi Provincial Key Laboratory of Infection and Immune Diseases Shaanxi Provincial People's Hospital Xi'an Shaanxi China"},{"name":"Shaanxi Province Research Center of Cell Immunological Engineering and Technology Shaanxi Provincial People's Hospital Xi'an Shaanxi China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,2,13]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11262-020-01822-9"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cnur.2019.02.009"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1101\/2024.08.13.607799"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cub.2024.05.053"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.nmni.2024.101434"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1007\/s13577-023-00923-5"},{"issue":"6","key":"e_1_2_9_8_1","first-page":"991","article-title":"Morphoproteomic Features of Pulmonary Influenza A (H1N1) With Therapeutic Implications: A Case Study","volume":"52","author":"Brown R. 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