{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T14:49:56Z","timestamp":1786978196780,"version":"build-2736575974"},"reference-count":31,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2025,2,6]],"date-time":"2025-02-06T00:00:00Z","timestamp":1738800000000},"content-version":"vor","delay-in-days":5,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal of Medical Virology"],"published-print":{"date-parts":[[2025,2]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    Little is known on the dynamics of human papillomavirus (HPV) viral load during pregnancy and on the impact of viral load on HPV vertical transmission. We described viral loads for several genotypes during pregnancy and analyse its association with vertical transmission. Data were analysed from the HERITAGE study, a cohort of pregnant women recruited between 2010 and 2016 in three centres in Canada. Vaginal samples were collected at the first and third trimesters of pregnancy, placental samples were collected at birth, and conjunctival, oral, pharyngeal, and genital samples were collected in children at birth and 3 months were tested for HPV DNA and viral load by Linear Array essay. The association between viral load and vertical transmission was measured using logistic regression. Odd ratios (ORs) and their 95% Confidence intervals (CI) were adjusted for age of the mother. We included women in the cohort infected with the 13 most common genotypes during pregnancy (\n                    <jats:italic>n<\/jats:italic>\n                    \u2009=\u2009287). A decrease in HPV viral load was observed during pregnancy (median difference between the third and first trimester of pregnancy\u2009=\u2009\u22120.005 copies\/cell [\n                    <jats:italic>p<\/jats:italic>\n                    \u2009&lt;\u20090.05]). Women with more than 2 HPV copies\/cell (compared to those with \u2264\u20092 copies) at first trimester had a statistically significant higher risk of vertical transmission (adjusted OR\u2009=\u20096.41; 95% CI: 1.10\u201337.34 for any genotypes and OR\u2009=\u200917.17; 95% CI: 1.18\u2013250.28 for HPV\u201016). Viral load values analysed continuously or categorized with different cut\u2010offs showed comparable results. HPV viral load varied during pregnancy and was strongly associated with HPV vertical transmission. The results provide a better understanding of risk factors associated with vertical transmission.\n                  <\/jats:p>","DOI":"10.1002\/jmv.70221","type":"journal-article","created":{"date-parts":[[2025,2,6]],"date-time":"2025-02-06T06:24:56Z","timestamp":1738823096000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Viral Load of Human Papillomavirus (HPV) During Pregnancy and Its Association With HPV Vertical Transmission"],"prefix":"10.1002","volume":"97","author":[{"given":"Em\u00e9ra Alice","family":"B\u00e9nard","sequence":"first","affiliation":[{"name":"Department of Social and Preventive Medicine Universit\u00e9 de Montr\u00e9al Montreal Canada"},{"name":"Centre de Recherche du Centre Hospitalier Universitaire Sainte\u2010Justine, Universit\u00e9 de Montr\u00e9al Montreal Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ana Maria","family":"Carceller","sequence":"additional","affiliation":[{"name":"Centre de Recherche du Centre Hospitalier Universitaire Sainte\u2010Justine, Universit\u00e9 de Montr\u00e9al Montreal Canada"},{"name":"Centre Hospitalier Universitaire Sainte\u2010Justine, Universit\u00e9 de Montr\u00e9al Montreal Canada"},{"name":"Department of Pediatrics Centre Hospitalier Universitaire Sainte\u2010Justine, Universit\u00e9 de Montr\u00e9al Montreal Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marie\u2010H\u00e9l\u00e8ne","family":"Mayrand","sequence":"additional","affiliation":[{"name":"Centre de Recherche du Centre Hospitalier de l'Universit\u00e9 de Montr\u00e9al Montreal Canada"},{"name":"Department of Obstetrics and Gynecology Universit\u00e9 de Montr\u00e9al Montreal Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jacques","family":"Lacroix","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Centre Hospitalier Universitaire Sainte\u2010Justine, Universit\u00e9 de Montr\u00e9al Montreal Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joseph","family":"Niyibizi","sequence":"additional","affiliation":[{"name":"Department of Social and Preventive Medicine Universit\u00e9 de Montr\u00e9al Montreal Canada"},{"name":"Centre de Recherche du Centre Hospitalier Universitaire Sainte\u2010Justine, Universit\u00e9 de Montr\u00e9al Montreal Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Louise","family":"Laporte","sequence":"additional","affiliation":[{"name":"Centre de Recherche du Centre Hospitalier Universitaire Sainte\u2010Justine, Universit\u00e9 de Montr\u00e9al Montreal Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emilie","family":"Com\u00e8te","sequence":"additional","affiliation":[{"name":"Centre de Recherche du Centre Hospitalier de l'Universit\u00e9 de Montr\u00e9al Montreal Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2025-8928","authenticated-orcid":false,"given":"Fran\u00e7ois","family":"Coutl\u00e9e","sequence":"additional","affiliation":[{"name":"Department of Social and Preventive Medicine Universit\u00e9 de Montr\u00e9al Montreal Canada"},{"name":"Centre de Recherche du Centre Hospitalier Universitaire Sainte\u2010Justine, Universit\u00e9 de Montr\u00e9al Montreal Canada"},{"name":"Centre de Recherche du Centre Hospitalier de l'Universit\u00e9 de Montr\u00e9al Montreal Canada"},{"name":"D\u00e9partement Clinique de M\u00e9decine de Laboratoire et de M\u00e9decine Services de Biologie Mol\u00e9culaire et D'Infectiologie"},{"name":"Centre Hospitalier de l'Universit\u00e9 de Montr\u00e9al Montr\u00e9al Qu\u00e9bec Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3293-7837","authenticated-orcid":false,"given":"Helen","family":"Trottier","sequence":"additional","affiliation":[{"name":"Department of Social and Preventive Medicine Universit\u00e9 de Montr\u00e9al Montreal Canada"},{"name":"Centre de Recherche du Centre Hospitalier Universitaire Sainte\u2010Justine, Universit\u00e9 de Montr\u00e9al Montreal Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"name":"The HERITAGE study group","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,2,6]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1097\/OLQ.0b013e3181666b05"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.5858\/2003-127-930-HPEAPH"},{"key":"e_1_2_11_4_1","unstructured":"P.Goggin FC F.Defay G.Lambert S.Mathieu\u2010Chartier V.Gilca andC.Sauvageau. 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