{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,12]],"date-time":"2026-06-12T17:36:59Z","timestamp":1781285819261,"version":"3.54.1"},"reference-count":43,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2025,2,12]],"date-time":"2025-02-12T00:00:00Z","timestamp":1739318400000},"content-version":"vor","delay-in-days":11,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal of Medical Virology"],"published-print":{"date-parts":[[2025,2]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:sec><jats:label\/><jats:p>Severe fever with thrombocytopenia syndrome (SFTS) is an infectious disease caused by a novel bunyavirus that poses a significant threat to human health. The aim of this study was to identify a precise and user\u2010friendly indicator for predicting the mortality of patients with SFTS. We retrospectively analyzed data from 181 hospitalized patients with SFTS. Inflammatory markers, including the neutrophil\u2010to\u2010lymphocyte ratio (NLR), lymphocyte\u2010to\u2010monocyte ratio (LMR), platelet\u2010to\u2010lymphocyte ratio (PLR), systemic inflammation index (SII), systemic inflammatory response index (SIRI), C\u2010reactive protein\u2010to\u2010albumin ratio (CAR), and inflammatory burden index (IBI), were compared between the survival group and the nonsurvival group. A receiver operating characteristic (ROC) curve was used to evaluate the diagnostic value of the IBI for the poor prognosis of SFTS patients. Survival analysis was performed using the Kaplan\u2012Meier (KM) method. Univariate and multivariate Cox regression models were used to explore factors influencing the prognosis of hospitalized patients with SFTS. The results indicate that patients with high IBI had significantly higher mortality rates than those with low IBI. ROC curve analysis revealed that the IBI had better predictive value than the other indicators did, with an optimal cutoff value of 0.878. Kaplan\u2013Meier survival analysis revealed that patients with high IBI had higher mortality rates and shorter survival times. Multivariate Cox regression analysis demonstrated that the IBI was an independent risk factor for poor prognosis in patients with SFTS. Therefore, the IBI can be used to help clinicians identify high\u2010risk individuals and implement timely therapeutic interventions.<\/jats:p><\/jats:sec>","DOI":"10.1002\/jmv.70225","type":"journal-article","created":{"date-parts":[[2025,2,12]],"date-time":"2025-02-12T13:44:21Z","timestamp":1739367861000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Inflammatory Burden Index as a Predictor of In\u2010Hospital Mortality in Patients With Severe Fever With Thrombocytopenia Syndrome"],"prefix":"10.1002","volume":"97","author":[{"ORCID":"https:\/\/orcid.org\/0009-0001-2378-1036","authenticated-orcid":false,"given":"Zhixian","family":"Yang","sequence":"first","affiliation":[{"name":"Department of Pediatrics The Second Affiliated Hospital of Anhui Medical University Hefei China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luonan","family":"Wang","sequence":"additional","affiliation":[{"name":"Faculty of Business, Economics and Law The University of Queensland Saint Lucia Queensland Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Baoyu","family":"Hong","sequence":"additional","affiliation":[{"name":"Department of Pediatrics The Second Affiliated Hospital of Anhui Medical University Hefei China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhicheng","family":"He","sequence":"additional","affiliation":[{"name":"Department of Pediatrics The Second Affiliated Hospital of Anhui Medical University Hefei China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qixing","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, The Fifth People's Hospital of Shanghai Fudan University Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tingting","family":"Shen","sequence":"additional","affiliation":[{"name":"Department of Pathology The First Affiliated Hospital of Anhui Medical University Hefei China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Junjie","family":"Shen","sequence":"additional","affiliation":[{"name":"The Second Clinical School of Medicine Anhui Medical University Hefei China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shichun","family":"Shen","sequence":"additional","affiliation":[{"name":"Department of Cardiology, The First Affiliated Hospital of USTC, Division of Life Sciences and Medicine University of Science and Technology of China Hefei China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yan","family":"Cheng","sequence":"additional","affiliation":[{"name":"Department of Pediatrics The Second Affiliated Hospital of Anhui Medical University Hefei China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chen","family":"Gong","sequence":"additional","affiliation":[{"name":"Department of Pediatrics The Second Affiliated Hospital of Anhui Medical University Hefei China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,2,12]]},"reference":[{"key":"e_1_2_12_2_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1010095"},{"key":"e_1_2_12_3_1","doi-asserted-by":"publisher","DOI":"10.1080\/22221751.2019.1710436"},{"key":"e_1_2_12_4_1","doi-asserted-by":"publisher","DOI":"10.1093\/infdis\/jit603"},{"key":"e_1_2_12_5_1","doi-asserted-by":"publisher","DOI":"10.3201\/eid2411.170756"},{"key":"e_1_2_12_6_1","doi-asserted-by":"publisher","DOI":"10.3201\/eid2505.181463"},{"issue":"56","key":"e_1_2_12_7_1","first-page":"82","article-title":"Prevalence of Severe Fever With Thrombocytopenia Syndrome Virus in Animals in Henan Province, China","volume":"8","author":"Huang X. 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