{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,5]],"date-time":"2026-05-05T06:51:39Z","timestamp":1777963899559,"version":"3.51.4"},"reference-count":34,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2025,2,24]],"date-time":"2025-02-24T00:00:00Z","timestamp":1740355200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100000024","name":"Canadian Institutes of Health Research","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000024","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal of Medical Virology"],"published-print":{"date-parts":[[2025,3]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>Congenital cytomegalovirus infections (cCMV) are an important cause of childhood neurodevelopmental deficits. Most cCMV are the result of maternal non\u2010primary infections during pregnancy, which can be due to reactivation or reinfection. To identify the rate of CMV reinfection during pregnancy and its risk factors. We performed a secondary analysis of CMV seropositive participants from two prospective cohort studies in Quebec, Canada. Antibody responses to four strain\u2010specific CMV epitopes located in glycoproteins B and H were measured by enzyme\u2010linked immunosorbent assay. CMV reinfection was defined as the appearance of an antibody response to a new epitope in the third compared to the first trimester. Risk factors for reinfection were assessed. Among 1614 participants, CMV reinfection was identified in 2.7% of participants, representing an incidence of 54.99 per 1000 person\u2010years at risk (95% confidence interval 39.95\u201373.82). Age, marital status, household income, continent of birth or ethnicity were not associated with reinfection during pregnancy. The incidence of CMV reinfection during pregnancy is like what has been reported for primary infection in Quebec. A greater understanding of the patterns of reinfection is needed to inform strategies to reduce the burden of disease from cCMV.<\/jats:p>","DOI":"10.1002\/jmv.70261","type":"journal-article","created":{"date-parts":[[2025,3,11]],"date-time":"2025-03-11T18:41:58Z","timestamp":1741718518000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Reinfection With Cytomegalovirus During Pregnancy: A Prospective Cohort Study in Canada"],"prefix":"10.1002","volume":"97","author":[{"ORCID":"https:\/\/orcid.org\/0009-0003-3672-3593","authenticated-orcid":false,"given":"Juliette","family":"St\u2010Georges","sequence":"first","affiliation":[{"name":"Women and Children's Infectious Diseases Center Azrieli CHU Sainte\u2010Justine Research Center Montreal Qu\u00e9bec Canada"},{"name":"Department of Obstetrics and Gynecology Universit\u00e9 de Montr\u00e9al Montr\u00e9al Qu\u00e9bec Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Safari Joseph","family":"Balegamire","sequence":"additional","affiliation":[{"name":"Women and Children's Infectious Diseases Center Azrieli CHU Sainte\u2010Justine Research Center Montreal Qu\u00e9bec Canada"},{"name":"Department of Social and Preventive Medicine \u00c9cole de Sant\u00e9 Publique de l'Universit\u00e9 de Montr\u00e9al Montr\u00e9al Qu\u00e9bec Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ariane","family":"Larouche","sequence":"additional","affiliation":[{"name":"Women and Children's Infectious Diseases Center Azrieli CHU Sainte\u2010Justine Research Center Montreal Qu\u00e9bec Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Suresh","family":"Boppana","sequence":"additional","affiliation":[{"name":"Department of Pediatrics and Microbiology University of Alabama at Birmingham Birmingham Alabama USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christian","family":"Renaud","sequence":"additional","affiliation":[{"name":"Women and Children's Infectious Diseases Center Azrieli CHU Sainte\u2010Justine Research Center Montreal Qu\u00e9bec Canada"},{"name":"Departments of Microbiology and Pediatrics, CHU Sainte\u2010Justine Universit\u00e9 de Montr\u00e9al Montr\u00e9al Qu\u00e9bec Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Beno\u00eet","family":"M\u00e2sse","sequence":"additional","affiliation":[{"name":"Department of Social and Preventive Medicine \u00c9cole de Sant\u00e9 Publique de l'Universit\u00e9 de Montr\u00e9al Montr\u00e9al Qu\u00e9bec Canada"},{"name":"Applied Clinical Research Unit CHU Sainte Justine Research Center Montreal Qu\u00e9bec Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yves","family":"Giguere","sequence":"additional","affiliation":[{"name":"CHU de Qu\u00e9bec\u2010Universit\u00e9 Laval Research Center Quebec City Qu\u00e9bec Canada"},{"name":"Department of Molecular Biology, Medical Biochemistry and Pathology, Faculty of Medicine Universit\u00e9 Laval Quebec City Qu\u00e9bec Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jean\u2010Claude","family":"Forest","sequence":"additional","affiliation":[{"name":"CHU de Qu\u00e9bec\u2010Universit\u00e9 Laval Research Center Quebec City Qu\u00e9bec Canada"},{"name":"Department of Molecular Biology, Medical Biochemistry and Pathology, Faculty of Medicine Universit\u00e9 Laval Quebec City Qu\u00e9bec Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Valerie","family":"Lamarre","sequence":"additional","affiliation":[{"name":"Women and Children's Infectious Diseases Center Azrieli CHU Sainte\u2010Justine Research Center Montreal Qu\u00e9bec Canada"},{"name":"Departments of Microbiology and Pediatrics, CHU Sainte\u2010Justine Universit\u00e9 de Montr\u00e9al Montr\u00e9al Qu\u00e9bec Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fran\u00e7ois","family":"Audibert","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology Universit\u00e9 de Montr\u00e9al Montr\u00e9al Qu\u00e9bec Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Soren","family":"Gantt","sequence":"additional","affiliation":[{"name":"Women and Children's Infectious Diseases Center Azrieli CHU Sainte\u2010Justine Research Center Montreal Qu\u00e9bec Canada"},{"name":"Departments of Microbiology and Pediatrics, CHU Sainte\u2010Justine Universit\u00e9 de Montr\u00e9al Montr\u00e9al Qu\u00e9bec Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Isabelle","family":"Boucoiran","sequence":"additional","affiliation":[{"name":"Women and Children's Infectious Diseases Center Azrieli CHU Sainte\u2010Justine Research Center Montreal Qu\u00e9bec Canada"},{"name":"Department of Obstetrics and Gynecology Universit\u00e9 de Montr\u00e9al Montr\u00e9al Qu\u00e9bec Canada"},{"name":"Department of Social and Preventive Medicine \u00c9cole de Sant\u00e9 Publique de l'Universit\u00e9 de Montr\u00e9al Montr\u00e9al Qu\u00e9bec Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2025,2,24]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00705-022-05516-5"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1469-0691.2011.03564.x"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpeds.2013.12.007"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.1002\/rmv.535"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.1093\/cid\/cix337"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00430-015-0399-9"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.1093\/cid\/ciq085"},{"key":"e_1_2_11_9_1","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.02392-16"},{"key":"e_1_2_11_10_1","doi-asserted-by":"publisher","DOI":"10.1542\/peds.104.1.55"},{"key":"e_1_2_11_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/1471-0528.13050"},{"key":"e_1_2_11_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1701-2163(15)30331-5"},{"key":"e_1_2_11_13_1","doi-asserted-by":"publisher","DOI":"10.1111\/ppe.12320"},{"key":"e_1_2_11_14_1","doi-asserted-by":"publisher","DOI":"10.1542\/peds.108.2.e35"},{"key":"e_1_2_11_15_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0252309"},{"key":"e_1_2_11_16_1","doi-asserted-by":"publisher","DOI":"10.1017\/s0950268815003167"},{"key":"e_1_2_11_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.diagmicrobio.2018.12.017"},{"key":"e_1_2_11_18_1","doi-asserted-by":"publisher","DOI":"10.1128\/cvi.00281-08"},{"key":"e_1_2_11_19_1","doi-asserted-by":"publisher","DOI":"10.1086\/649903"},{"key":"e_1_2_11_20_1","doi-asserted-by":"publisher","DOI":"10.1093\/infdis\/jiu263"},{"key":"e_1_2_11_21_1","doi-asserted-by":"publisher","DOI":"10.3855\/jidc.539"},{"key":"e_1_2_11_22_1","unstructured":"The World Bank. The World by Income and Region 2024 https:\/\/datatopics.worldbank.org\/world-development-indicators\/the-world-by-income-and-region.html."},{"key":"e_1_2_11_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajog.2009.11.018"},{"key":"e_1_2_11_24_1","doi-asserted-by":"publisher","DOI":"10.1002\/rmv.1744"},{"key":"e_1_2_11_25_1","doi-asserted-by":"publisher","DOI":"10.1159\/000343167"},{"key":"e_1_2_11_26_1","doi-asserted-by":"publisher","DOI":"10.1056\/nejm198204223061601"},{"key":"e_1_2_11_27_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13643-022-02004-4"},{"key":"e_1_2_11_28_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12884-019-2360-1"},{"key":"e_1_2_11_29_1","doi-asserted-by":"publisher","DOI":"10.1002\/rmv.2034"},{"key":"e_1_2_11_30_1","doi-asserted-by":"publisher","DOI":"10.1080\/22221751.2021.1969290"},{"key":"e_1_2_11_31_1","doi-asserted-by":"publisher","DOI":"10.1093\/ve\/vew017"},{"key":"e_1_2_11_32_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.2221797120"},{"key":"e_1_2_11_33_1","doi-asserted-by":"publisher","DOI":"10.1016\/B978-1-4160-6400-8.00023-7"},{"key":"e_1_2_11_34_1","doi-asserted-by":"publisher","DOI":"10.3390\/pathogens11050568"},{"key":"e_1_2_11_35_1","doi-asserted-by":"publisher","DOI":"10.21769\/BioProtoc.4464"}],"container-title":["Journal of Medical Virology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/jmv.70261","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,12,8]],"date-time":"2025-12-08T13:09:04Z","timestamp":1765199344000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/jmv.70261"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,2,24]]},"references-count":34,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2025,3]]}},"alternative-id":["10.1002\/jmv.70261"],"URL":"https:\/\/doi.org\/10.1002\/jmv.70261","archive":["Portico"],"relation":{},"ISSN":["0146-6615","1096-9071"],"issn-type":[{"value":"0146-6615","type":"print"},{"value":"1096-9071","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,2,24]]},"assertion":[{"value":"2024-11-17","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-02-11","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-02-24","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e70261"}}