{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,17]],"date-time":"2026-02-17T04:04:40Z","timestamp":1771301080606,"version":"3.50.1"},"reference-count":52,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2025,2,25]],"date-time":"2025-02-25T00:00:00Z","timestamp":1740441600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal of Medical Virology"],"published-print":{"date-parts":[[2025,3]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    <jats:italic>Mayaro virus<\/jats:italic>\n                    (MAYV) is an arthritogenic arbovirus that causes a debilitating illness that can progress to a chronic rheumatic disease characterized by persistent viral replication in macrophages within joint tissues. Here, we report that MAYV\u2010infected macrophages release decondensed DNA traps (DNA extracellular traps, DETs) through a mechanism driven by the production of reactive oxygen species and peptidyl arginine deiminase activation, resembling the classical mechanism of pathogen clearance by activated neutrophils. Unlike traditional pathogen clearance observed for NETs released by neutrophils, MAYV\u2010induced DETs did not inactivate the virus. Instead, DET\u2010ensnared viruses are internalized by neighboring uninfected macrophages, increasing the number of infected cells. Collectively, these findings suggest that MAYV\u2010containing DETs act as a \u201cTrojan horse\u201d that facilitates viral dissemination within inflamed tissues, connecting macrophage\u2010mediated inflammatory response to viral persistence in the articular tissue in chronic MAYV disease.\n                  <\/jats:p>","DOI":"10.1002\/jmv.70262","type":"journal-article","created":{"date-parts":[[2025,3,11]],"date-time":"2025-03-11T18:54:17Z","timestamp":1741719257000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["DNA Extracellular Traps Released by Mayaro Virus\u2010Infected Macrophages Act as a Platform for Virus Dissemination"],"prefix":"10.1002","volume":"97","author":[{"given":"Ana S.","family":"Carvalho","sequence":"first","affiliation":[{"name":"Instituto de Bioqu\u00edmica M\u00e9dica Leopoldo de Meis Universidade Federal do Rio de Janeiro Rio de Janeiro Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gean Carlo","family":"Pereira\u2010Silva","sequence":"additional","affiliation":[{"name":"Institudo de Microbiologia Paulo de Goes Universidade Federal do Rio de Janeiro Rio de Janeiro Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Julia M. 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