{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,4]],"date-time":"2026-08-04T15:47:55Z","timestamp":1785858475303,"version":"3.56.0"},"reference-count":30,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2025,3,3]],"date-time":"2025-03-03T00:00:00Z","timestamp":1740960000000},"content-version":"vor","delay-in-days":2,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal of Medical Virology"],"published-print":{"date-parts":[[2025,3]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    In this report, the clinical performance of Liferiver HarmoniaHPV and Liferiver VenusHPV was evaluated under the VALHUDES framework. Five hundred and twenty\u2010three\u00a0women collected first\u2010void urine (FVU) with Colli\u2010Pee and vaginal samples with Evalyn Brush or Qvintip. Cervical samples were taken with the Cervex Brush by a clinician. Both vaginal and cervical samples were resuspended in 20\u2009mL ThinPrep. Triplet samples from 499 women were tested with HarmoniaHPV and VenusHPV tests. The clinical accuracy of HarmoniaHPV did not differ in FVU and vaginal self\u2010samples versus cervical samples. The relative sensitivity for CIN2+ on FVU and vaginal samples was 0.95 [95% CI 0.89\u20131.02] and 0.95 [95% CI 0.88\u20131.02], respectively. Relative specificity for &lt;\u2009CIN2 was 0.95 [0.86\u20131.04] on FVU and 0.93 [0.86\u20131.01] on vaginal samples. VenusHPV demonstrated lower sensitivity on both self\u2010sample types, whereas the specificity was similar to cervical samples. Post\u2010hoc adjustment of the VenusHPV\n                    <jats:italic>C<\/jats:italic>\n                    <jats:sub>t<\/jats:sub>\n                    \u2010values improved sensitivity (ratio FVU\/cervical\u2009=\u20090.94 [95% CI 0.88\u20131.00]; ratio vaginal\/cervical\u2009=\u20090.96 [95% CI 0.92\u20131.01]) without compromising specificity (ratio FVU\/cervical\u2009=\u20091.00 [0.92\u20131.09]; ratio vaginal\/cervical\u2009=\u20090.95 [95% CI 0.88\u20131.02]) on both self\u2010samples. In conclusion, HarmoniaHPV and VenusHPV tests demonstrated similar clinical accuracy on FVU and vaginal self\u2010 versus cervical samples, although VenusHPV test required cut\u2010off optimization.\n                  <\/jats:p>","DOI":"10.1002\/jmv.70273","type":"journal-article","created":{"date-parts":[[2025,3,12]],"date-time":"2025-03-12T02:26:07Z","timestamp":1741746367000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Accuracy of Liferiver HarmoniaHPV and VenusHPV Assays on Urine and Vaginal Self\u2010Samples"],"prefix":"10.1002","volume":"97","author":[{"given":"Ardashel","family":"Latsuzbaia","sequence":"first","affiliation":[{"name":"Unit of Cancer Epidemiology, Belgian Cancer Centre, Sciensano Brussels Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1842-7478","authenticated-orcid":false,"given":"Severien","family":"Van 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