{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,17]],"date-time":"2026-07-17T23:31:37Z","timestamp":1784331097862,"version":"3.55.0"},"reference-count":36,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2025,3,21]],"date-time":"2025-03-21T00:00:00Z","timestamp":1742515200000},"content-version":"vor","delay-in-days":20,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal of Medical Virology"],"published-print":{"date-parts":[[2025,3]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>Human herpesvirus 6B (HHV\u20106B) encephalitis is a rare but severe complication of hematopoietic cell transplantation. This study investigated the pathogenesis of HHV\u20106B encephalitis by comparing plasma proteomic profiles of four pediatric patients with HHV\u20106B encephalitis to three with asymptomatic HHV\u20106B reactivation following umbilical cord blood transplantation (UCBT). Plasma proteomic profiling was conducted using liquid chromatography\u2010mass spectrometry. Overall, 260 proteins were identified and quantified in plasma samples. At the onset of HHV\u20106B encephalitis and asymptomatic reactivation, 20 and 24 proteins, respectively, were significantly upregulated compared to their respective pre\u2010onset levels. Of these, 11 proteins were uniquely upregulated in HHV\u20106B encephalitis. S100\u2010A9 and S100\u2010A8 were the most and second\u2010most upregulated proteins in HHV\u20106B encephalitis, respectively. Elevated plasma S100A8\/A9 heterodimer levels were confirmed via enzyme\u2010linked immunosorbent assay in three of the four patients with HHV\u20106B encephalitis. Pathway analysis identified neutrophil degranulation as the most enriched category among upregulated proteins in HHV\u20106B encephalitis. Additionally, proteins related to the protein\u2010lipid complex remodeling pathway were more prominently upregulated in HHV\u20106B encephalitis than in asymptomatic reactivation. Proteomic analysis revealed distinct plasma protein profiles between HHV\u20106B encephalitis and asymptomatic HHV\u20106B reactivation in pediatric UCBT recipients. The inflammatory response mediated by S100A8\/A9 proteins may play a critical role in the pathogenesis of HHV\u20106B encephalitis. These findings indicate that proteomic analysis may provide novel insights into the host response to HHV\u20106B reactivation and the subsequent development of HHV\u20106B encephalitis.<\/jats:p>","DOI":"10.1002\/jmv.70311","type":"journal-article","created":{"date-parts":[[2025,3,23]],"date-time":"2025-03-23T06:57:39Z","timestamp":1742713059000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Plasma Proteomic Profiles of Pediatric Patients With Human Herpesvirus 6B Encephalitis Following Umbilical Cord Blood Transplantation"],"prefix":"10.1002","volume":"97","author":[{"given":"Kazunori","family":"Haruta","sequence":"first","affiliation":[{"name":"Department of Pediatrics Nagoya University Graduate School of Medicine Nagoya Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuto","family":"Fukuda","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Nagoya University Graduate School of Medicine Nagoya Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hisateru","family":"Yamaguchi","sequence":"additional","affiliation":[{"name":"Department of Medical Technology Yokkaichi Nursing and Medical Care University Yokkaichi Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3942-7098","authenticated-orcid":false,"given":"Yoshiki","family":"Kawamura","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Fujita Health University School of Medicine Toyoake Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takako","family":"Suzuki","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Nagoya University Graduate School of Medicine Nagoya Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuka","family":"Torii","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Nagoya University Graduate 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