{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,10]],"date-time":"2026-09-10T01:47:21Z","timestamp":1789004841667,"version":"build-2803163510"},"reference-count":12,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2025,3,20]],"date-time":"2025-03-20T00:00:00Z","timestamp":1742428800000},"content-version":"vor","delay-in-days":19,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal of Medical Virology"],"published-print":{"date-parts":[[2025,3]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>Human coronavirus OC43 (HCoV\u2010OC43) is predominantly associated with mild respiratory infections. HCoV\u2010OC43 also has neuroinvasive properties, and severe encephalitis has been described in immunocompromised patients, with fatal outcomes due to the lack of specific antiviral treatment. We report a case of severe febrile encephalitis attributed to HCoV\u2010OC43 that progressively worsened over 3 months in a 65\u2010year\u2010old immunocompromised man. Clinical symptoms improved remarkably after treatment with remdesivir, with an increase of the Glasgow Coma Score from 8 to 14 within 7 days.<\/jats:p>","DOI":"10.1002\/jmv.70314","type":"journal-article","created":{"date-parts":[[2025,3,20]],"date-time":"2025-03-20T03:15:46Z","timestamp":1742440546000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Remdesivir for the Treatment of Human Coronavirus OC43 Encephalitis"],"prefix":"10.1002","volume":"97","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3631-184X","authenticated-orcid":false,"given":"Jacques","family":"Fourgeaud","sequence":"first","affiliation":[{"name":"Universit\u00e9 Paris Cit\u00e9, URP 7328 FETUS Paris France"},{"name":"Microbiology Department AP\u2010HP, H\u00f4pital Necker\u2010Enfants malades Paris 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