{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,8]],"date-time":"2026-04-08T07:45:37Z","timestamp":1775634337173,"version":"3.50.1"},"reference-count":48,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2025,4,7]],"date-time":"2025-04-07T00:00:00Z","timestamp":1743984000000},"content-version":"vor","delay-in-days":6,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal of Medical Virology"],"published-print":{"date-parts":[[2025,4]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    This retrospective cohort study evaluated the association between obstructive sleep apnea (OSA) and the risk of respiratory syncytial virus (RSV) infection and its complications using data from the TriNetX US Collaborative Database. Patients diagnosed with OSA (n = 1\u2009061\u2009261) and matched controls (\n                    <jats:italic>n<\/jats:italic>\n                    \u2009=\u20093\u2009479\u2009494) were identified via ICD\u201010\u2010CM codes. Propensity score matching adjusted for 19 covariates to balance baseline characteristics. Over a follow\u2010up period ranging from 1 day to 1 year post\u2010index, patients with OSA demonstrated a significantly higher incidence of RSV infection (0.18% vs. 0.08%; HR: 2.194, 95% CI: 2.025\u20132.378,\n                    <jats:italic>p<\/jats:italic>\n                    \u2009&lt;\u20090.0001). Additionally, patients with OSA exhibited increased risks for severe RSV\u2010related complications, including respiratory failure (HR: 1.291, 95% CI: 1.147\u20131.453), hospitalization (HR: 1.114, 95% CI: 1.026\u20131.210), and admission to critical care (HR: 1.329, 95% CI: 1.118\u20131.579). Sensitivity analyses confirmed the robustness of these findings across various observation periods, database subsets, study timelines, and inclusion criteria. Subgroup analyses stratified by age and gender also consistently supported the primary results. These findings suggest that OSA is associated with elevated risks of RSV infection and related severe outcomes, indicating the need for further studies to validate these results and potentially classify OSA patients as a high\u2010risk group for RSV infection.\n                  <\/jats:p>","DOI":"10.1002\/jmv.70323","type":"journal-article","created":{"date-parts":[[2025,4,8]],"date-time":"2025-04-08T05:04:00Z","timestamp":1744088640000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Obstructive Sleep Apnea and Risk of Respiratory Syncytial Viral Infection: A Retrospective Multi\u2010Institution Cohort Study"],"prefix":"10.1002","volume":"97","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1710-256X","authenticated-orcid":false,"given":"Sunny Ssu\u2010Yu","family":"Chen","sequence":"first","affiliation":[{"name":"School of Medicine Chung Shan Medical University Taichung Taiwan"},{"name":"Institute of Neuroscience National Yang Ming Chiao Tung University Taipei Taiwan"},{"name":"Department of General Surgery, Da Vinci Minimally Invasive Surgery Center Chung Shan Medical University Hospital Taichung Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tina Ting\u2010An","family":"Lin","sequence":"additional","affiliation":[{"name":"School of Medicine Chung Shan Medical University Taichung Taiwan"},{"name":"Department of General Surgery, Da Vinci Minimally Invasive Surgery Center Chung Shan Medical University Hospital Taichung Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yi\u2010Lin","family":"Chiang","sequence":"additional","affiliation":[{"name":"Department of Medical Education Chung Shan Medical University Hospital Taichung Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chien\u2010Yun","family":"Chen","sequence":"additional","affiliation":[{"name":"School of Medicine National Yang Ming Chiao Tung University Taipei Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hui\u2010Yuan","family":"Chen","sequence":"additional","affiliation":[{"name":"Division of Medical Research, Kaohsiung Veterans General Hospital Kaohsiung Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6920-8799","authenticated-orcid":false,"given":"Yao\u2010Min","family":"Hung","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine Division of Nephrology, Taitung Hospital, Ministry of Health and Welfare Taitung Taiwan"},{"name":"Master Program in Biomedicine, College of Science and Engineering National Taitung University Taitung Taiwan"},{"name":"College of Health and Nursing Meiho University Pingtung Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1016-2233","authenticated-orcid":false,"given":"Renin","family":"Chang","sequence":"additional","affiliation":[{"name":"Division of Medical Research, Kaohsiung Veterans General Hospital Kaohsiung Taiwan"},{"name":"Department of Recreation and Sports Management Tajen University Pintung Taiwan"},{"name":"Institute of Medicine Chung Shan Medical University Taichung Taiwan"},{"name":"Department of Emergency Medicine Kaohsiung Veterans General Hospital Kaohsiung Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2025,4,7]]},"reference":[{"key":"e_1_2_12_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(13)60734-5"},{"key":"e_1_2_12_3_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199304293281704"},{"key":"e_1_2_12_4_1","doi-asserted-by":"publisher","DOI":"10.1183\/09031936.00043210"},{"key":"e_1_2_12_5_1","doi-asserted-by":"publisher","DOI":"10.1093\/aje\/kws342"},{"key":"e_1_2_12_6_1","doi-asserted-by":"publisher","DOI":"10.1001\/archinternmed.2009.266"},{"key":"e_1_2_12_7_1","first-page":"171","article-title":"Epidemiology of Adult Obstructive Sleep Apnoea Syndrome in India","volume":"131","author":"Sharma S. 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