{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,26]],"date-time":"2026-10-26T01:58:23Z","timestamp":1792979903190,"version":"4.5.0"},"reference-count":39,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2025,4,8]],"date-time":"2025-04-08T00:00:00Z","timestamp":1744070400000},"content-version":"vor","delay-in-days":7,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal of Medical Virology"],"published-print":{"date-parts":[[2025,4]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>Tenofovir alafenamide (TAF) is widely used for chronic hepatitis B (CHB) treatment due to its improved renal and bone safety compared to tenofovir disoproxil fumarate (TDF). However, emerging evidence suggests that TAF may adversely affect lipid metabolism, raising concerns about potential cardiovascular risks. A systematic review and meta\u2010analysis following PRISMA guidelines was conducted. Studies comparing lipid profile changes in CHB patients receiving TAF, TDF, or entecavir (ETV) were retrieved from PubMed, Cochrane, and Embase. Primary outcomes included changes in total cholesterol (TC), triglycerides (TG), low\u2010density lipoprotein (LDL), and high\u2010density lipoprotein (HDL). Sensitivity analyses were performed to assess potential confounders, including lipid\u2010lowering therapy. Trial sequential analysis (TSA) was used to evaluate the sufficiency of evidence. A total of 23 studies (5 RCTs, 18 observational) were included. Observational data showed significant increases in TC (MD\u2009=\u200910.74\u2009mg\/dL), TG (MD\u2009=\u200911.56\u2009mg\/dL), LDL (MD\u2009=\u20093.08\u2009mg\/dL), and HDL (MD\u2009=\u20097.51\u2009mg\/dL) with TAF versus TDF. Meta\u2010analysis of RCTs confirmed these findings, showing TC (MD\u2009=\u200918.28\u2009mg\/dL), LDL (MD\u2009=\u200913.09\u2009mg\/dL), and HDL (MD\u2009=\u20094.95\u2009mg\/dL) elevations. TAF is associated with increased lipid levels, likely due to the loss of TDF's lipid\u2010lowering effect. While its cardiovascular risk remains uncertain, clinicians should monitor lipid profiles in CHB patients on TAF, particularly those at high cardiovascular risk.<\/jats:p>","DOI":"10.1002\/jmv.70331","type":"journal-article","created":{"date-parts":[[2025,4,8]],"date-time":"2025-04-08T08:01:32Z","timestamp":1744099292000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Impact of Tenofovir Alafenamide on Lipid Profiles in Chronic Hepatitis B Patients: Systematic Review and Meta\u2010Analysis"],"prefix":"10.1002","volume":"97","author":[{"given":"Ping\u2010Yu","family":"Hsu","sequence":"first","affiliation":[{"name":"Department of Pharmacy Chi\u2010Mei Medical Center Tainan Taiwan"},{"name":"Department of Statistics National Cheng Kung University Tainan Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hui\u2010Chen","family":"Su","sequence":"additional","affiliation":[{"name":"Department of 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