{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T06:13:31Z","timestamp":1790230411491,"version":"4.1.0"},"reference-count":57,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2025,4,10]],"date-time":"2025-04-10T00:00:00Z","timestamp":1744243200000},"content-version":"vor","delay-in-days":9,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal of Medical Virology"],"published-print":{"date-parts":[[2025,4]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>West Africa serves as a critical region for the co\u2010circulation of mosquito\u2010borne flaviviruses, which often precipitate sporadic outbreaks. This study investigated the seropositivity to dengue virus serotypes 1\u20134 (DENV\u20101\u20134), Zika virus (ZIKV), yellow fever virus (YFV), and West Nile virus (WNV) in three regions of Senegal: Sindia, Thies, and Kedougou. We retrospectively analyzed 470 serum samples for flavivirus immunoglobulin G (IgG) using a DENV\u20102 envelope (E) ELISA. Our findings revealed an overall flavivirus seroprevalence of 37.23%. Among the DENV\u20102 E IgG positive samples, the proportion of subjects with IgG to DENV\u20101\u20134, ZIKV, YFV, or WNV NS1 was 57.14%, 12.57%, 80.57%, and 17.14%, respectively, with 66.86% harboring neutralizing antibodies against two or more flaviviruses. We also identified that residents in Sindia (ZIKV, aOR, 9.428; 95% CI: 1.882\u201347.223 and WNV, aOR, 6.039; 95% CI: 1.855\u201319.658) and Kedougou (ZIKV, aOR, 7.487; 95% CI: 1.658\u201333.808 and WNV, aOR, 1.142; 95% CI: 0.412\u20133.164) were at significant risk for ZIKV and WNV exposure. This study underscores the complexity of flavivirus epidemiology in West Africa and the necessity for enhanced surveillance to inform public health strategies.<\/jats:p>","DOI":"10.1002\/jmv.70338","type":"journal-article","created":{"date-parts":[[2025,4,10]],"date-time":"2025-04-10T08:32:55Z","timestamp":1744273975000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Seropositivity to Dengue, Zika, Yellow Fever, and West Nile Viruses in Senegal, West Africa"],"prefix":"10.1002","volume":"97","author":[{"given":"Sebastian","family":"Gallon","sequence":"first","affiliation":[{"name":"Rutgers Global Health Institute Rutgers University New Brunswick New Jersey USA"},{"name":"Department of Medicine, Division of Allergy, Immunology, and Infectious Diseases and Child Health Institute of New Jersey Rutgers Robert Wood Johnson Medical School New Brunswick New Jersey 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