{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,13]],"date-time":"2026-07-13T18:31:33Z","timestamp":1783967493253,"version":"3.55.0"},"reference-count":21,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2025,4,9]],"date-time":"2025-04-09T00:00:00Z","timestamp":1744156800000},"content-version":"vor","delay-in-days":8,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal of Medical Virology"],"published-print":{"date-parts":[[2025,4]]},"abstract":"ABSTRACT<\/jats:title>\n \n To improve access to colposcopy for women with abnormal cervical cancer screening results, this study evaluated the diagnostic accuracy of the internally developed Siriraj portable digital cervicography device for detecting cervical intraepithelial neoplasia grade 2 or worse (CIN2\n +<\/jats:sup>\n ) and compared its performance with standard colposcopy. Consenting eligible women underwent examination using both the Siriraj portable digital cervicography device and standard colposcopy. Images from each method were independently evaluated by a physician blinded to the other images and histology results. The primary outcome was the diagnostic performance of both methods for detecting CIN2\n +<\/jats:sup>\n . Diagnostic accuracy was compared using Cochran's\n Q<\/jats:italic>\n test, with a significance threshold of\n p<\/jats:italic>\n \u2009<\u20090.05. A total of 450 women participated, with histologically confirmed CIN2\n +<\/jats:sup>\n in 91 cases (20.1%), including 45 women diagnosed with cervical intraepithelial neoplasia grade 3 or worse (CIN3\n +<\/jats:sup>\n ). Incorporating colposcopic impressions, the modified Reid's colposcopic index, and the modified Swede score, the Siriraj portable digital cervicography device demonstrated a diagnostic accuracy of 81.3% for CIN2\n +<\/jats:sup>\n , whereas standard colposcopy ranged from 79.1% to 81.6%. No significant difference in diagnostic accuracy was found among the six evaluative methods (\n p<\/jats:italic>\n \u2009=\u20090.558). The Siriraj portable digital cervicography device shows promise as an alternative to standard colposcopy for detecting CIN2\n +<\/jats:sup>\n , particularly in low\u2010resource settings. While it enables remote evaluation by trained colposcopists, its diagnostic performance remains dependent on expert image interpretation. Standardizing biopsy protocols and integrating AI\u2010assisted analysis could further enhance its clinical utility.\n <\/jats:p>\n \n Trial Registration:<\/jats:bold>\n TCTR20230907004; registered on September 7, 2023;\n https:\/\/thaiclinicaltrials.org<\/jats:ext-link>\n .\n <\/jats:p>","DOI":"10.1002\/jmv.70339","type":"journal-article","created":{"date-parts":[[2025,4,9]],"date-time":"2025-04-09T09:02:56Z","timestamp":1744189376000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Diagnostic Accuracy of the Siriraj Portable Digital Cervicography Device Versus Standard Colposcopy for Detecting CIN2\n +<\/sup>\n Lesions"],"prefix":"10.1002","volume":"97","author":[{"given":"Methawee","family":"Ularnwong","sequence":"first","affiliation":[{"name":"Department of Obstetrics & Gynecology, Division of Gynecologic Oncology, Faculty of Medicine Siriraj Hospital Mahidol University Bangkok Thailand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Suchanan","family":"Hanamornroongruang","sequence":"additional","affiliation":[{"name":"Department of Pathology, Faculty of Medicine Siriraj Hospital Mahidol University Bangkok Thailand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9888-7479","authenticated-orcid":false,"given":"Irene","family":"Ruengkhachorn","sequence":"additional","affiliation":[{"name":"Department of Obstetrics & Gynecology, Division of Gynecologic Oncology, Faculty of Medicine Siriraj Hospital Mahidol University Bangkok Thailand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wathirada","family":"Karnchanabanyong","sequence":"additional","affiliation":[{"name":"Department of Obstetrics & Gynecology, Division of Gynecologic Oncology, Faculty of Medicine Siriraj Hospital Mahidol University Bangkok Thailand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sompop","family":"Kuljarusnont","sequence":"additional","affiliation":[{"name":"Department of Obstetrics & Gynecology, Division of Gynecologic Oncology, Faculty of Medicine Siriraj Hospital Mahidol University Bangkok Thailand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pattama","family":"Chaopotong","sequence":"additional","affiliation":[{"name":"Department of Obstetrics & Gynecology, Division of Gynecologic Oncology, Faculty of Medicine Siriraj Hospital Mahidol University Bangkok Thailand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nida","family":"Jareemit","sequence":"additional","affiliation":[{"name":"Department of Obstetrics & Gynecology, Division of Gynecologic Oncology, Faculty of Medicine Siriraj Hospital Mahidol University Bangkok Thailand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pornprom","family":"Ittiamornlert","sequence":"additional","affiliation":[{"name":"Department of Obstetrics & Gynecology, Division of Gynecologic Oncology, Faculty of Medicine Siriraj Hospital Mahidol University Bangkok Thailand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sarocha","family":"Boonkate","sequence":"additional","affiliation":[{"name":"Department of Obstetrics & Gynecology, Division of Gynecologic Oncology, Faculty of Medicine Siriraj Hospital Mahidol University Bangkok Thailand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sirakarn","family":"Rochwipaporn","sequence":"additional","affiliation":[{"name":"Department of Nursing, Division of Obstetrics and Gynaecological Nursing, Faculty of Medicine Siriraj Hospital Mahidol University Bangkok Thailand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vilaiwan","family":"Surapo","sequence":"additional","affiliation":[{"name":"Department of Nursing, Division of Obstetrics and Gynaecological Nursing, Faculty of Medicine Siriraj Hospital Mahidol University Bangkok Thailand"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,4,9]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.3322\/caac.21834"},{"key":"e_1_2_10_3_1","unstructured":"WHO WHO Guideline for Screening and Treatment of Cervical Pre\u2010Cancer Lesions for Cervical Cancer Prevention(WHO 2021) https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/34314129."},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1097\/LGT.0000000000000525"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.3390\/curroncol30060425"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejogrb.2023.08.369"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1097\/LGT.0000000000000342"},{"issue":"4","key":"e_1_2_10_8_1","first-page":"1145","article-title":"Digital Cervicography by Simply Portable Device as an Alternative Test for Cervical Cancer Screening in Rural Area of Thailand","volume":"19","author":"Singhakum N.","year":"2018","journal-title":"Asian Pacific Journal of Cancer Prevention: APJCP"},{"key":"e_1_2_10_9_1","unstructured":"Cervical Screening: Programme and Colposcopy Management \u201c4. 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