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Despite the genetic divergence between these variants, HIV\u20101\/M+O dual infections have resulted in the emergence of HIV\u20101\/MO intergroup recombinant forms, with 20 unique HIV\u20101\/MO recombinant forms (URF_MO) currently described, raising the question of a possible benefit of the recombination and the modalities of their emergence. This review summarized the current knowledge of HIV\u20101\/MO recombinant forms, including their virological and genetic characteristics, phylogenetic analysis, genome profiles, and breakpoints number and location. This study also identified the potential impacts of HIV\u20101\/MO recombination on diagnosis, monitoring, and treatment, as well as the replicative capacity of such recombinants. This review highlighted the greater diversity and complexity of HIV\u20101\/MO recombinants than originally thought, offering new research perspectives on their emergence and virological properties.<\/jats:p>","DOI":"10.1002\/jmv.70358","type":"journal-article","created":{"date-parts":[[2025,4,29]],"date-time":"2025-04-29T05:34:53Z","timestamp":1745904893000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Genetic Evolution Between HIV\u20101 Groups M and O: HIV\u20101\/MO Recombinant Forms"],"prefix":"10.1002","volume":"97","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1162-720X","authenticated-orcid":false,"given":"Alice","family":"Moisan","sequence":"first","affiliation":[{"name":"Univ Rouen Normandie, Universit\u00e9 de Caen Normandie, INSERM, Normandie Univ, DYNAMICURE UMR 1311, CHU Rouen, Department of Virology National Reference Center of HIV Rouen 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