{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,5]],"date-time":"2026-02-05T11:29:56Z","timestamp":1770290996924,"version":"3.49.0"},"reference-count":36,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2025,5,20]],"date-time":"2025-05-20T00:00:00Z","timestamp":1747699200000},"content-version":"vor","delay-in-days":19,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal of Medical Virology"],"published-print":{"date-parts":[[2025,5]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:p>In chronic hepatitis B (CHB) patients under antiviral treatment, liver injury, as evidenced by elevated alanine transaminase (ALT), is associated with unfavorable outcomes and needs effective treatment. The interaction between gut microbiota and liver injury in CHB patients remains unclear. Using a case\u2010control design, 28 cases with elevated ALT and 28 matched controls with normal ALT were randomly selected from CHB patients with viral control. Clinical characteristics were comparable between groups. Metagenomic sequencing revealed that <jats:italic>Bacteroides fragilis<\/jats:italic> was decreased in cases and exhibited the greatest disparity between cases and controls. Mice colonized by gut microbiota from cases exhibited more severe liver damage in both LPS\u2010induced and MCD diet\u2010induced liver injury models, and had a lower abundance of <jats:italic>B. fragilis<\/jats:italic> compared to mice colonized by gut microbiota from controls. Oral gavage of <jats:italic>B. fragilis<\/jats:italic> improved both LPS\u2010induced and MCD diet\u2010induced liver injury. Metabolomics analysis revealed that the levels of 7\u2010Ketolithocholic acid (7\u2010Keto\u2010LCA) were positively correlated with <jats:italic>B. fragilis<\/jats:italic> and significantly increased in the cultural supernatant of <jats:italic>B. fragilis<\/jats:italic>. Consistently, 7\u2010Keto\u2010LCA exerted protective effects against both LPS\u2010induced and MCD diet\u2010induced liver damage. Targeting gut microbiota might be a promising therapeutic treatment for alleviation residual liver inflammation in CHB patients with viral control.<\/jats:p>","DOI":"10.1002\/jmv.70395","type":"journal-article","created":{"date-parts":[[2025,5,20]],"date-time":"2025-05-20T09:50:57Z","timestamp":1747734657000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Reduction of <i>Bacteroides fragilis<\/i> in Gut Microbiome of Chronic Hepatitis B Patients Promotes Liver Injury"],"prefix":"10.1002","volume":"97","author":[{"given":"Qiuhong","family":"You","sequence":"first","affiliation":[{"name":"State Key Laboratory of Multi\u2010organ Injury Prevention and Treatment, Key Laboratory of Infectious Diseases Research in South China, Ministry of Education, Guangdong Provincial Key Laboratory of Viral Hepatitis Research, Guangdong Provincial Clinical Research Center for Viral Hepatitis, Guangdong Institute of Hepatology, 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