{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,13]],"date-time":"2025-10-13T15:42:06Z","timestamp":1760370126140,"version":"3.43.0"},"reference-count":41,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2025,5,22]],"date-time":"2025-05-22T00:00:00Z","timestamp":1747872000000},"content-version":"vor","delay-in-days":21,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal of Medical Virology"],"published-print":{"date-parts":[[2025,5]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:p>Understanding whether individuals with mental illness, who face challenges related to healthcare barriers, are more vulnerable to postacute sequelae of COVID\u201019 is limited. Here, we investigated the potential association between pre\u2010existing mental illness and postacute sequelae of COVID\u201019 across 12 major health domains and 141 specific diseases in COVID\u201019 survivors. The large\u2010scale, population\u2010based cohorts from South Korea (K\u2010COV\u2010N cohort) used in the study included 8\u2009632\u2009221 individuals aged 20 years or older who were infected with SARS\u2010CoV\u20102 between January 1, 2020, and December 31, 2022. The risk of postacute sequelae of COVID\u201019 was assessed in the 1:2 propensity score\u2010matched cohorts, comprising 12 major health domains and 141 diseases based on the ICD\u201010 code, following mental illness among patients with COVID\u201019. We assessed the time attenuation effect of major health outcomes after 30 days following SARS\u2010CoV\u20102 infection. Multiple subgroup analyses were conducted by severity of mental illness, COVID\u201019 severity, vaccination, and SARS\u2010CoV\u20102 strain. After 1:2 exposure\u2010driven propensity score matching, we identified 1\u2009341\u2009320 participants with mental illness (mean age, 49.51 [SD, 13.82] years; 62.27% female) and 2\u2009653\u2009597 controls (mean age, 48.78 [SD, 13.75] years; 62.03% female). Individuals with mental illness exhibited significantly higher risks across all 12 major health domains, including: infectious and parasitic events (adjusted hazard ratio [aHR], 1.36 [95% CI, 1.33\u20131.38]), blood and immune\u2010related events (1.21 [1.17\u20131.26]), endocrine, nutritional, and metabolic events (1.21 [1.18\u20131.24]), nerve\u2010related events (2.13 [2.07\u20132.19]), eye\u2010related events (1.29 [1.25\u20131.34]), ear and mastoid events (1.52 [1.50\u20131.54]), circulatory events (1.25 [1.17\u20131.35]), respiratory events (1.26 [1.24\u20131.29]), digestive events (1.41 [1.40\u20131.41]), skin\u2010related events (1.34 [1.30\u20131.38]), musculoskeletal events (1.42 [1.41\u20131.43]), and genitourinary events (1.54 [1.18\u20132.01]). Of the 141 postacute sequelae of COVID\u201019, 133 showed significantly increased risks. The association was strongest within the first 6\u201312 months after SARS\u2010CoV\u20102 infection, with risks progressively attenuating beyond 12 months and nearly disappearing after 18 months. Subgroup analysis revealed that individuals with mild mental illness exhibited higher aHRs for 11 of the 12 health outcome domains compared with those with severe mental illness. Altogether, our findings show the increased risk of postacute sequelae of COVID\u201019 across 12 major health domains in individuals with mental illness among COVID\u201019 survivors. These findings highlight the need for targeted monitoring and intervention strategies to address the vulnerabilities of this population, particularly during the post\u2010COVID\u201019 period.<\/jats:p>","DOI":"10.1002\/jmv.70406","type":"journal-article","created":{"date-parts":[[2025,5,22]],"date-time":"2025-05-22T03:34:18Z","timestamp":1747884858000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Postacute Sequelae of COVID\u201019 Across 12 Major Health Domains and 141 Diseases in Individuals With Mental Illness Among COVID\u201019 Survivors: A Population\u2010Based Cohort Study in South Korea"],"prefix":"10.1002","volume":"97","author":[{"given":"Jiseung","family":"Kang","sequence":"first","affiliation":[{"name":"School of Health and Environmental Science Korea University College of Health Science Seoul South Korea"},{"name":"Department of Health and Safety Convergence Science Korea University Graduate School 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