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In addition to conventional pulmonary lesions, a range of neurological injury symptoms have been identified in clinical practice, but the aetiology of neurological disorders linked to SARS\u2010CoV\u20102 infection remains poorly understood. Syrian hamsters, which are highly susceptible to SARS\u2010CoV\u20102 infection, exhibit a disease phenotype similar to that observed in human COVID\u201019 patients. In this study, a hamster model of COVID\u201019 infection was used to analyze molecular changes in different tissues at various time points post infection with distinct strains using proteomic and phosphoproteomic approaches. Multi\u2010omics analysis showed that SARS\u2010COV\u20102 infection triggers sustained downregulation of the abundance and phosphorylation levels of neuronal and synapse\u2010associated proteins in the brain, suggesting that neuronal damage persists even during the recovery period. Additionally, infections with SARS\u2010CoV\u20102 may contribute to the onset of long\u2010term symptoms of COVID\u201019 by impacting energy metabolism, neurotransmitter release, and synaptic transmission pathways. This study provides a comprehensive molecular profile of hamsters infected with different SARS\u2010CoV\u20102 strains in different tissues, offering foundational insights into the pathogenic mechanisms of COVID\u201019.<\/jats:p>","DOI":"10.1002\/jmv.70410","type":"journal-article","created":{"date-parts":[[2025,5,28]],"date-time":"2025-05-28T02:59:15Z","timestamp":1748401155000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Dynamic Molecular Changes in Brain, Lung, and Heart of Hamsters Infected With SARS\u2010CoV\u20102: Insights From a Severe and Recovery Phase Model"],"prefix":"10.1002","volume":"97","author":[{"given":"Wanjun","family":"Peng","sequence":"first","affiliation":[{"name":"State Key Laboratory of Common Mechanism Research for Major Diseases, Department of Biochemistry and Molecular Biology, Chinese Academy of Medical Sciences and Peking Union Medical College Institute of Basic Medical Sciences 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