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HPIV\u20103 quantification and whole\u2010genome sequencing were performed on HPIV\u20103 positive respiratory samples. Clinical characteristics, infection progression, incidence rates of respiratory viruses within the hospital and detection of respiratory viruses were documented, along with the reinforcement of infection prevention and control (IPC) measures implemented. Between November 2022, and January 2023, HPIV\u20103 was identified in 20 of 113 hematology patients (17.7%), of whom 80% had multiple myeloma. A majority of HPIV\u20103\u2010positive patients developed pneumonia (60%), and mortality was notably higher (35%) compared to patients who were negative (3%, <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.0001). Respiratory HPIV\u20103 viral loads were similar between patients with and without pneumonia. In parallel, HPIV\u20103 incidence in the hospital overall was lower than in the hematology unit (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.0001). Air virus screening showed the detection of HPIV\u20103 in the air in different areas, and whole\u2010genome sequencing confirmed the circulation of a single HPIV\u20103 strain. Strengthened IPC measures were associated with the containment of the outbreak. HPIV\u20103 has high epidemic potential in patients with multiple myeloma and causes severe infections. Our findings highlight the need for routine HPIV\u20103 testing in hematology units.<\/jats:p>","DOI":"10.1002\/jmv.70411","type":"journal-article","created":{"date-parts":[[2025,5,22]],"date-time":"2025-05-22T03:39:39Z","timestamp":1747885179000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Clinical and Epidemiological Insights into a Parainfluenza Virus Type 3 Outbreak in Multiple Myeloma Patients"],"prefix":"10.1002","volume":"97","author":[{"ORCID":"https:\/\/orcid.org\/0009-0003-3508-4558","authenticated-orcid":false,"given":"Sarah","family":"Timsit","sequence":"first","affiliation":[{"name":"Virology Department AP\u2010HP, H\u00f4pital Saint Louis Paris France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Guillaume","family":"Mellon","sequence":"additional","affiliation":[{"name":"Infection Prevention and Control Unit, AP\u2010HP, H\u00f4pital Saint\u2010Louis Paris 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