{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,8]],"date-time":"2026-10-08T22:03:39Z","timestamp":1791497019337,"version":"4.3.4"},"reference-count":38,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2025,6,6]],"date-time":"2025-06-06T00:00:00Z","timestamp":1749168000000},"content-version":"vor","delay-in-days":5,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal of Medical Virology"],"published-print":{"date-parts":[[2025,6]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    The symptoms of long COVID are well\u2010documented. However, the long\u2010term effects beyond 2 years remain poorly understood due to a lack of data. This systematic review and meta\u2010analysis examined the prevalence of persistent symptoms in COVID\u201019 survivors 3 years following initial SARS\u2010CoV\u20102 infection. PubMed, MEDLINE (Ovid), CENTRAL, Web of Science, Scopus, and Embase were searched from inception of the databases up to July 20, 2024, by two independent researchers for articles reporting on the prevalence of persistent symptoms 3 years' post\u2010infection of people who survived COVID\u201019 infection. We employed a random\u2010effect model for the pooled analysis, and the meta\u2010analytical effect size was prevalence for the applicable end\u2010points,\n                    <jats:italic>I<\/jats:italic>\n                    <jats:sup>2<\/jats:sup>\n                    statistics, and quality assessment of included studies using the Newcastle\u2010Ottawa Scale. Eleven articles were included after the literature search yielded 223 potentially relevant articles. We found that among patients with long COVID, fatigue, sleep disturbances, and dyspnea were the most common symptoms. Pooled analysis showed that the proportion of individuals experiencing at least one persistent symptom 3 years post\u2010COVID\u201019 is 20% (95% confidence interval [CI]: 8\u201343). The prevalence of persistent symptoms was dyspnea (12%; 95% CI: 10\u201315), fatigue (11%; 95% CI: 6\u201320), insomnia (11%; 95% CI: 2\u201337), loss of smell (7%; 95% CI: 5\u20138), loss of taste (7%; 95% CI: 3\u201316), and anxiety (6%; 95% CI: 1\u201332). Prevalence of other findings include impaired diffusion capacity (42%; 95% CI: 34\u201350) and impaired forced expiratory volume in 1\u2009s (10%; 95% CI: 8\u201312). Our findings confirm the persistence of unresolved symptoms 3 years post\u2010COVID\u201019 infection, with implications for future research, healthcare policy, and patient care.\n                  <\/jats:p>","DOI":"10.1002\/jmv.70429","type":"journal-article","created":{"date-parts":[[2025,6,6]],"date-time":"2025-06-06T08:20:09Z","timestamp":1749198009000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":50,"title":["Long\u2010Term Sequelae of COVID\u201019: A Systematic Review and Meta\u2010Analysis of Symptoms 3 Years Post\u2010SARS\u2010CoV\u20102 Infection"],"prefix":"10.1002","volume":"97","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4792-027X","authenticated-orcid":false,"given":"Masoud","family":"Rahmati","sequence":"first","affiliation":[{"name":"CEReSS\u2010Health Service Research and Quality of Life Center Assistance Publique\u2010Hopitaux de Marseille, Aix\u2010Marseille University Marseille 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