{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,27]],"date-time":"2026-05-27T15:21:29Z","timestamp":1779895289451,"version":"3.53.1"},"reference-count":26,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2025,6,12]],"date-time":"2025-06-12T00:00:00Z","timestamp":1749686400000},"content-version":"vor","delay-in-days":11,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal of Medical Virology"],"published-print":{"date-parts":[[2025,6]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:p>Children with an early severe respiratory syncytial virus (RSV) infection have an increased risk of wheezing later in life. This longitudinal study aimed to investigate whether children with a mild RSV infection taken care of in a primary health care setting had an increased incidence of wheezing in the 2 years following infection compared to children with other respiratory infections (RSV\u2010negative). Nasal swabs of children with acute respiratory infections were examined for 23 pathogens by multiplex PCR. 216 RSV\u2010positive and RSV\u2010negative (<jats:italic>N<\/jats:italic>\u2009=\u2009201) matched for age, gender and time of diagnosis were followed for 2 years using telemedical control to record the occurrence of wheezing, hospitalization and frequency of respiratory tract infections. RSV\u2010positive patients showed a 48% lower risk (OR 0.520, <jats:italic>p<\/jats:italic>\u2009=\u20090.03) of developing wheezing in the 2\u2010year observation period compared to the RSV\u2010negative group; Rhinovirus\u2010positive patients had a trendwise increased risk (OR 1.47, <jats:italic>p<\/jats:italic>\u2009=\u20090.0872). These data were also reflected in a reduced prescription rate of short acting beta agonists in the RSV group. In conclusion, mild RSV infections led to fewer wheezing episodes in RSV\u2010positive compared to RSV\u2010negative patients. Rhinovirus infections appear to increase wheezing. Our data are consistent with the idea that there could be a dose\u2010effect relationship with RSV infections.<\/jats:p>","DOI":"10.1002\/jmv.70441","type":"journal-article","created":{"date-parts":[[2025,6,12]],"date-time":"2025-06-12T08:49:23Z","timestamp":1749718163000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Long Term Sequelae of Mild RSV Infections in Healthy Children Aged 0\u20133 Years in the Primary Care Setting\u2014A Prospective Two Year Follow Up Observational Study"],"prefix":"10.1002","volume":"97","author":[{"given":"Paulina","family":"Ehlmaier","sequence":"first","affiliation":[{"name":"First Vienna Pediatric Medical Center Vienna Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter","family":"Voitl","sequence":"additional","affiliation":[{"name":"First Vienna Pediatric Medical Center Vienna Austria"},{"name":"Medical University of Vienna Vienna Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Angela","family":"Riepl","sequence":"additional","affiliation":[{"name":"First Vienna Pediatric Medical Center Vienna Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lena","family":"Lischka","sequence":"additional","affiliation":[{"name":"First Vienna Pediatric Medical Center Vienna Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julian J. 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