{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,29]],"date-time":"2026-05-29T14:13:42Z","timestamp":1780064022508,"version":"3.54.0"},"reference-count":30,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2025,7,2]],"date-time":"2025-07-02T00:00:00Z","timestamp":1751414400000},"content-version":"vor","delay-in-days":1,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2025,7,1]],"date-time":"2025-07-01T00:00:00Z","timestamp":1751328000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal of Medical Virology"],"published-print":{"date-parts":[[2025,7]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    High\u2010risk HPV (hrHPV) is the necessary cause of cervical cancer with HPV16\/18 accounting for around 70% of the cases worldwide, while other non\u2010HPV16\/18 hrHPV genotypes prevail in ~95% of high\u2010grade lesions. Understanding regional genotype distribution of hrHPV types not covered by the nonavalent vaccine is crucial for evaluating vaccine effectiveness and enhancing population\u2010based screening (PBS). The objective of the present study is to update hrHPV genotype prevalence in a non\u2010vaccinated cohort of 1200 hrHPV\u2010positive women from the Dutch PBS using INNO\u2010LiPA HPV Genotyping Extra\u2010II to identify 32 individual HPV genotypes in self\u2010sampled material. HrHPV prevalence for all 32 genotypes, also grouped by bivalent, quadrivalent, and nonavalent vaccine types (2vHPV, 4vHPV, and 9vHPV), was reported by histologic diagnosis and age. The most common genotypes were HPV16 (394,33%), especially in younger women, followed by HPV31 (216,18%) and HPV52 (199,17%). 2vHPV genotypes were found in 23% (\n                    <jats:italic>n<\/jats:italic>\n                    \u2009=\u200990) of NILM cases, 27% (\n                    <jats:italic>n<\/jats:italic>\n                    \u2009=\u200984) of CIN0\/CIN1, 45% (\n                    <jats:italic>n<\/jats:italic>\n                    \u2009=\u200974) of CIN2, 71% (\n                    <jats:italic>n<\/jats:italic>\n                    \u2009=\u2009219) of CIN3, and 92% (\n                    <jats:italic>n<\/jats:italic>\n                    \u2009=\u200912) of cervical cancers. In comparison, 9vHPV genotypes appeared in 60% (\n                    <jats:italic>n<\/jats:italic>\n                    \u2009=\u2009240) of NILM, 69% (\n                    <jats:italic>n<\/jats:italic>\n                    \u2009=\u2009218) of CIN0\/CIN1, 88% (\n                    <jats:italic>n<\/jats:italic>\n                    \u2009=\u2009145) of CIN2, 94% (\n                    <jats:italic>n<\/jats:italic>\n                    \u2009=\u2009289) of CIN3, and all cervical cancers (\n                    <jats:italic>n<\/jats:italic>\n                    \u2009=\u200913). HrHPV types not included in 9vHPV had an overall prevalence of 19% (\n                    <jats:italic>n<\/jats:italic>\n                    \u2009=\u2009225), with 88% (197\/225) found in NILM or CIN0\/CIN1. This study highlights vaccine\u2010type HPV in all cancer cases and many high\u2010grade lesions, reinforcing the need for improved vaccination efforts and broader protection.\n                  <\/jats:p>","DOI":"10.1002\/jmv.70461","type":"journal-article","created":{"date-parts":[[2025,7,2]],"date-time":"2025-07-02T06:50:26Z","timestamp":1751439026000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Distribution of Human Papillomavirus Genotypes in Real\u2010World Cervical Self\u2010Collected Scrapings From the Dutch Cervical Cancer Screening Program"],"prefix":"10.1002","volume":"97","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4520-1706","authenticated-orcid":false,"given":"Kelly Melisa","family":"Casta\u00f1eda","sequence":"first","affiliation":[{"name":"Department of Epidemiology University of Groningen, University Medical Center Groningen Groningen the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jolien","family":"de Waard","sequence":"additional","affiliation":[{"name":"Department of Pathology &amp; Medical Biology University of Groningen, University Medical Center Groningen Groningen the Netherlands"},{"name":"Department of Gynecologic Oncology, Cancer Research Center Groningen University of Groningen, University Medical Centre Groningen Groningen the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lorian","family":"Slagter\u2010Menkema","sequence":"additional","affiliation":[{"name":"Department of Pathology &amp; Medical Biology University of Groningen, University Medical Center Groningen Groningen the Netherlands"},{"name":"Department of Otorhinolaryngology University of Groningen, University Medical Center Groningen Groningen the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mirjam","family":"Mastik","sequence":"additional","affiliation":[{"name":"Department of Pathology &amp; Medical Biology University of Groningen, University Medical Center Groningen Groningen the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Floris Adriaan","family":"Vuijk","sequence":"additional","affiliation":[{"name":"MSD B.V. Haarlem the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rudolf Lambertus Maria","family":"Bekkers","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology Radboud University Medical Center, Nijmegen Nijmegen the Netherlands"},{"name":"Department of Obstetrics and Gynecology Catharina Hospital Eindhoven the Netherlands"},{"name":"GROW School forty Oncology and Reproduction Maastricht University Maastricht the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Geertruida Hendrika","family":"de Bock","sequence":"additional","affiliation":[{"name":"Department of Epidemiology University of Groningen, University Medical Center Groningen Groningen the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gijsbertha Barendina Alida","family":"Wisman","sequence":"additional","affiliation":[{"name":"Department of Gynecologic Oncology, Cancer Research Center Groningen University of Groningen, University Medical Centre Groningen Groningen the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ed","family":"Schuuring","sequence":"additional","affiliation":[{"name":"Department of Pathology &amp; Medical Biology University of Groningen, University Medical Center Groningen Groningen the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,7,2]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.3322\/CAAC.21660"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/J.VACCINE.2012.06.083"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.1002\/PATH.4424"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.1177\/0956462420958577"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.1002\/HED.23808"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.1002\/IJC.27485"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/J.CMI.2021.04.031"},{"key":"e_1_2_11_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/J.PVR.2015.06.003"},{"key":"e_1_2_11_10_1","doi-asserted-by":"publisher","DOI":"10.1371\/JOURNAL.PONE.0272205"},{"key":"e_1_2_11_11_1","doi-asserted-by":"publisher","DOI":"10.1080\/01443615.2018.1493441"},{"key":"e_1_2_11_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/J.PVR.2016.05.004"},{"issue":"2","key":"e_1_2_11_13_1","article-title":"Et Al. 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