{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T01:20:45Z","timestamp":1791854445962,"version":"4.3.4"},"reference-count":44,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2025,6,30]],"date-time":"2025-06-30T00:00:00Z","timestamp":1751241600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2025,6,30]],"date-time":"2025-06-30T00:00:00Z","timestamp":1751241600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal of Medical Virology"],"published-print":{"date-parts":[[2025,7]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>Human adenoviruses of species B (HAdV\u2010B) can cause upper respiratory tract infections and conjunctivitis, but also severe lower respiratory tract infections (LRTI). Although HAdV\u2010associated LRTI are non\u2010notifiable in Germany, typing data of our Adenovirus Reference Laboratory indicated an HAdV\u2010B3 epidemic in 2023, with 67 samples initially typed as HAdV\u2010B3 compared to &lt;\u200910\/year in the previous years. Circulation of a novel, highly virulent HAdV\u2010B3 strain was suspected and complete viral genomic sequencing performed, revealing a recombinant phylogeny of the penton gene (P), which originated from HAdV\u2010B7, whereas hexon (H) and fiber (F) genes originated from HAdV\u2010B3. Therefore, this virus was acknowledged by the Adenovirus Working Group as the novel recombinant genotype 114 (P7H3F3). Interestingly, BLAST search of the HAdV\u2010B114 prototype sequence showed 99.91% identity to the old HAdV\u2010B genome type 3a. Additionally, multiple complete adenovirus genomic sequences labeled as HAdV\u2010B3 during the last two decades had &gt;\u200999.8% identity, suggesting long\u2010term circulation of HAdV\u2010B114 although the recombinant phylogeny of its penton region had not been recognized. This detailed analysis of an HAdV epidemic associated with ocular and respiratory infections, including severe LRTI, led to the discovery of a novel genotype HAdV\u2010B114, which is rather a neglected, re\u2010emergent than an emerging virus.<\/jats:p>","DOI":"10.1002\/jmv.70464","type":"journal-article","created":{"date-parts":[[2025,6,30]],"date-time":"2025-06-30T09:59:54Z","timestamp":1751277594000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":13,"title":["An Epidemic of Respiratory and Ocular Infections Caused by the Reemergence of a Recombinant Human Adenovirus, the Novel Type HAdV\u2010B114 (P7H3F3)"],"prefix":"10.1002","volume":"97","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3791-4709","authenticated-orcid":false,"given":"Tina","family":"Ganzenmueller","sequence":"first","affiliation":[{"name":"Institute for Medical Virology, University Hospital Tuebingen Tuebingen Germany"},{"name":"German Center for 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