{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T14:48:18Z","timestamp":1786978098390,"version":"build-2736575974"},"reference-count":29,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2025,6,27]],"date-time":"2025-06-27T00:00:00Z","timestamp":1750982400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2025,6,27]],"date-time":"2025-06-27T00:00:00Z","timestamp":1750982400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal of Medical Virology"],"published-print":{"date-parts":[[2025,7]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>Co\u2010infection with HIV and chronic viral hepatitis (HBV and HCV) contributes to increased morbidity and complicates treatment outcomes. However, in Southwest China, a high\u2010burden region epidemiological data on HIV\/HBV and HIV\/HCV co\u2010infection remain limited. We conducted a retrospective cohort study including 146\u2009537 HIV\u20101 infected individuals in Guangxi from 2003 to 2024. We compared co\u2010infection prevalence and risk factors in two time periods (before 2013 and after 2013). Logistic regression was used to identify risk factors for co\u2010infection. CD4\u2009+\u2009T cell recovery was analyzed using generalized estimating equation (GEE) models. The overall prevalence of HIV\/HCV and HIV\/HBV co\u2010infection was 5.41% and 9.92%, respectively. HIV\/HCV co\u2010infection significantly declined from 9.69% before 2013% to 3.03% after 2013, especially among sexually transmitted cases. HIV\/HBV co\u2010infection remained relatively stable. Intravenous drug users (IDU), low education level, and age 30\u201349 years were major risk factors. Coinfected patients showed poorer CD4\u2009+\u2009T cell recovery, especially those with HIV\/HCV. HIV\/HCV co\u2010infection has decreased over time in Guangxi, while HIV\/HBV remains prevalent. Co\u2010infection negatively impacts immune recovery. Targeted prevention and early treatment strategies are needed, especially for high\u2010risk populations such as IDUs.<\/jats:p>","DOI":"10.1002\/jmv.70465","type":"journal-article","created":{"date-parts":[[2025,6,27]],"date-time":"2025-06-27T08:10:22Z","timestamp":1751011822000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Epidemiological Trends and CD4+T Cell Recovery in HIV\u20101 Patients With HCV\/HBV Co\u2010Infection: A Retrospective Cohort Study in Southwest China (2003\u20132024)"],"prefix":"10.1002","volume":"97","author":[{"given":"Xianwu","family":"Pang","sequence":"first","affiliation":[{"name":"Guangxi Key Laboratory of Major Infectious Disease Prevention and Control and Biosafety Emergency Response, Guangxi Key Laboratory of AIDS Prevention and Control and Achievement Transformation Guangxi Zhuang Autonomous Region Center for Disease Control and Prevention Nanning China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qin","family":"He","sequence":"additional","affiliation":[{"name":"Guangxi Key Laboratory of Major Infectious Disease Prevention and Control and Biosafety Emergency Response, Guangxi Key Laboratory of AIDS Prevention and Control and Achievement Transformation Guangxi Zhuang Autonomous Region Center for Disease Control and Prevention Nanning China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jinghua","family":"Huang","sequence":"additional","affiliation":[{"name":"Guangxi Key Laboratory of Major Infectious Disease Prevention and Control and Biosafety Emergency Response, Guangxi Key Laboratory of AIDS Prevention and Control and Achievement Transformation Guangxi Zhuang Autonomous Region Center for Disease Control and Prevention Nanning China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kailing","family":"Tang","sequence":"additional","affiliation":[{"name":"Guangxi Key Laboratory of Major Infectious Disease Prevention and Control and Biosafety Emergency Response, Guangxi Key Laboratory of AIDS Prevention and Control and Achievement Transformation Guangxi Zhuang Autonomous Region Center for Disease Control and Prevention Nanning China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jie","family":"Ma","sequence":"additional","affiliation":[{"name":"Guangxi Key Laboratory of Major Infectious Disease Prevention and Control and Biosafety Emergency Response, Guangxi Key Laboratory of AIDS Prevention and Control and Achievement Transformation Guangxi Zhuang Autonomous Region Center for Disease Control and Prevention Nanning China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ningye","family":"Fang","sequence":"additional","affiliation":[{"name":"Guangxi Key Laboratory of Major Infectious Disease Prevention and Control and Biosafety Emergency Response, Guangxi Key Laboratory of AIDS Prevention and Control and Achievement Transformation Guangxi Zhuang Autonomous Region Center for Disease Control and Prevention Nanning China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haomin","family":"Xie","sequence":"additional","affiliation":[{"name":"Guangxi Key Laboratory of Major Infectious Disease Prevention and Control and Biosafety Emergency Response, Guangxi Key Laboratory of AIDS Prevention and Control and Achievement Transformation Guangxi Zhuang Autonomous Region Center for Disease Control and Prevention Nanning China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jingxi","family":"Su","sequence":"additional","affiliation":[{"name":"Guangxi Key Laboratory of Major Infectious Disease Prevention and Control and Biosafety Emergency Response, Guangxi Key Laboratory of AIDS Prevention and Control and Achievement Transformation Guangxi Zhuang Autonomous Region Center for Disease Control and Prevention Nanning China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dabin","family":"Liang","sequence":"additional","affiliation":[{"name":"Guangxi Key Laboratory of Major Infectious Disease Prevention and Control and Biosafety Emergency Response, Guangxi Key Laboratory of AIDS Prevention and Control and Achievement Transformation Guangxi Zhuang Autonomous Region Center for Disease Control and Prevention Nanning China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qiuying","family":"Zhu","sequence":"additional","affiliation":[{"name":"Guangxi Key Laboratory of Major Infectious Disease Prevention and Control and Biosafety Emergency Response, Guangxi Key Laboratory of AIDS Prevention and Control and Achievement Transformation Guangxi Zhuang Autonomous Region Center for Disease Control and Prevention Nanning China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4414-9611","authenticated-orcid":false,"given":"Shujia","family":"Liang","sequence":"additional","affiliation":[{"name":"Guangxi Key Laboratory of Major Infectious Disease Prevention and Control and Biosafety Emergency Response, Guangxi Key Laboratory of AIDS Prevention and Control and Achievement Transformation Guangxi Zhuang Autonomous Region Center for Disease Control and Prevention Nanning China"},{"name":"Guangxi Key Laboratory for the Prevention and Control of Viral Hepatitis Guangxi Zhuang Autonomous Region Center for Disease Control and Prevention Nanning China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,6,27]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1473-3099(16)30325-5"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/jvh.13217"},{"key":"e_1_2_11_4_1","first-page":"953","article-title":"NCAIDS\/STD National AIDS Venereal Disease in the Second Quarter of 2023","volume":"29","year":"2023","journal-title":"Journal China AIDS Sex Transmitted Diseases"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/S2468-1253(23)00197-8"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/S2468-1253(21)00472-6"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.2174\/1570162X17666190703163838"},{"issue":"2","key":"e_1_2_11_8_1","first-page":"111","article-title":"Chinese Center for Disease Control and Prevention. Update on the AIDS\/STD Epidemic in China in December 2017","volume":"24","year":"2018","journal-title":"Chin J AIDS STD"},{"key":"e_1_2_11_9_1","unstructured":"The Peoples Government of Guangxi Zhuang Autonomous Region. Implementation Plan of Guangxi AIDS Conquering Project (2010\u20102014); 2010.http:\/\/www.gxzf.gov.cn\/zwgk\/zfwj\/zzqrmzfwj_25542\/t950471.shtml."},{"key":"e_1_2_11_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.vaccine.2013.03.045"},{"key":"e_1_2_11_11_1","unstructured":"Department of Disease Prevention and Control National Health Commission of the People's Republic of China. China has Achieved Remarkable Results in Controlling Hepatitis B. 2013.http:\/\/www.nhfpc.gov.cn\/jkj\/s3582\/201307\/518216575e544109b2caca07fca3b430.shtml."},{"key":"e_1_2_11_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.drugalcdep.2012.05.028"},{"key":"e_1_2_11_13_1","doi-asserted-by":"publisher","DOI":"10.1097\/QAD.0000000000002374"},{"key":"e_1_2_11_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/S2352-3018(22)00098-4"},{"issue":"11","key":"e_1_2_11_15_1","first-page":"1079","article-title":"Effects of Differential First\u2010Line Antiretroviral Therapy (ART) Regimens on Mortality Among Hiv\/Aids Children in Southwest China: A 15\u2010year Retrospective Cohort Study","volume":"36","author":"Chen Q. 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