{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,29]],"date-time":"2026-05-29T14:13:28Z","timestamp":1780064008677,"version":"3.54.0"},"reference-count":48,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2025,7,1]],"date-time":"2025-07-01T00:00:00Z","timestamp":1751328000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2025,7,1]],"date-time":"2025-07-01T00:00:00Z","timestamp":1751328000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal of Medical Virology"],"published-print":{"date-parts":[[2025,7]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    In Guinea\u2010Bissau, cervical cancer (CC) screening is unimplemented and data on high\u2010risk human papillomavirus (hr\u2010HPV) prevalence among women living with HIV (WLWH) are limited. This study assessed the acceptability of first\u2010void urine (FVU) and vaginal self\u2010sampling for HPV testing and the HPV prevalence and among WLWH in Guinea\u2010Bissau. This multicenter cross\u2010sectional study included a total of 498 WLWH aged 18\u201364 years. At nine HIV\u2010clinics, women self\u2010collected paired FVU and vaginal samples (VS), using the Colli\u2010Pee and Evalyn Brush device, respectively. The Allplex HPV\u2010HR assay was used for HPV DNA testing. Acceptability and preferences were assessed using questionnaires and hr\u2010HPV genotype concordance was analyzed using Cohen's kappa (\n                    <jats:italic>\u03ba<\/jats:italic>\n                    ). Overall, 78% (\n                    <jats:italic>n<\/jats:italic>\n                    \u2009=\u2009389\/498) tested hr\u2010HPV positive (FVU and\/or VS). Good hr\u2010HPV genotype concordance was observed (range 0.64\u20130.78) between sample types. HPV52 and HPV58 were the most prevalent genotypes (both 21%) followed by HPV66 and HPV16 (both 18%). Both modalities were well\u2010accepted regarding comfort and ease of use, however, the urine device was preferred. Clinic\u2010based FVU and VS self\u2010sampling was feasible and well\u2010accepted by WLWH, with urine sampling as the most preferred modality. The high hr\u2010HPV prevalence underscores the urgency of integrating HPV\u2010based CC screening and treatment into HIV care.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:bold>Trial Registration:<\/jats:bold>\n                    NCT05783167 (clinicaltrials.gov)\n                  <\/jats:p>","DOI":"10.1002\/jmv.70466","type":"journal-article","created":{"date-parts":[[2025,7,1]],"date-time":"2025-07-01T09:50:48Z","timestamp":1751363448000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Feasibility of First\u2010Void Urinary and Vaginal Self\u2010Sampling for High\u2010Risk Human Papillomavirus Testing Among Women Living With Human Immunodeficiency Virus in Guinea\u2010Bissau\u2014A Multicenter Cross\u2010Sectional Study"],"prefix":"10.1002","volume":"97","author":[{"ORCID":"https:\/\/orcid.org\/0009-0005-4042-4427","authenticated-orcid":false,"given":"Kia L\u00e6rke","family":"Madsen","sequence":"first","affiliation":[{"name":"Bandim Health Project, INDEPTH Network Bissau Guinea\u2010Bissau"},{"name":"Aarhus University Aarhus Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mette","family":"Tranberg","sequence":"additional","affiliation":[{"name":"Department of Public Health Programs University Clinic for Cancer Screening, Randers Regional Hospital Randers Denmark"},{"name":"Department of Pathology Randers Regional Hospital Randers Denmark"},{"name":"Department of Clinical Medicine Aarhus University Aarhus Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pia","family":"N\u00f8rgaard","sequence":"additional","affiliation":[{"name":"Department of Pathology Randers Regional Hospital Randers Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Candida","family":"Medina","sequence":"additional","affiliation":[{"name":"National HIV Program Ministry of Health Bissau Guinea\u2010Bissau"},{"name":"Hospital Nacional Sim\u00e3o Mendes Bissau Guinea\u2010Bissau"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Merete","family":"Storgaard","sequence":"additional","affiliation":[{"name":"Department of Infectious Diseases Aarhus University Hospital Aarhus Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alex","family":"Vorsters","sequence":"additional","affiliation":[{"name":"Centre for the Evaluation of Vaccination, Vaccine &amp; Infectious Disease Institute, Faculty of Medicine and Health Sciences University of Antwerp Wilrijk Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1842-7478","authenticated-orcid":false,"given":"Severien","family":"Van Keer","sequence":"additional","affiliation":[{"name":"Centre for the Evaluation of Vaccination, Vaccine &amp; Infectious Disease Institute, Faculty of Medicine and Health Sciences University of Antwerp Wilrijk Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bo Langhoff","family":"H\u00f8nge","sequence":"additional","affiliation":[{"name":"Bandim Health Project, INDEPTH Network Bissau Guinea\u2010Bissau"},{"name":"Department of Infectious Diseases Aarhus University Hospital Aarhus Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sanne","family":"Jespersen","sequence":"additional","affiliation":[{"name":"Bandim Health Project, INDEPTH Network Bissau Guinea\u2010Bissau"},{"name":"Aarhus University Aarhus Denmark"},{"name":"Department of Infectious Diseases Aarhus University Hospital Aarhus Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,7,1]]},"reference":[{"key":"e_1_2_13_2_1","doi-asserted-by":"publisher","DOI":"10.1086\/376996"},{"key":"e_1_2_13_3_1","unstructured":"UNAIDS The Little\u2010Known Links Between Cervical Cancer and HIV(UNAIDS 2022) https:\/\/www.unaids.org\/en\/cervical_cancer."},{"key":"e_1_2_13_4_1","unstructured":"World Health Organization (WHO) Human Papillomavirus (HPV) and Cervical Cancer(WHO 2022) https:\/\/www.who.int\/news-room\/fact-sheets\/detail\/human-papillomavirus-(hpv)-and-cervical-cancer."},{"key":"e_1_2_13_5_1","first-page":"6","article-title":"Incidence and Risk Factors Associated With Cervical Cancer in Sub\u2010Saharan Africa: A Systematic Review","volume":"3","author":"Kamiza A.","year":"2020","journal-title":"Archives of Women and Health Care"},{"key":"e_1_2_13_6_1","unstructured":"WHO WHO Guideline for Screening and Treatment of Cervical Pre\u2010Cancer Lesions for Cervical Cancer Prevention Second Edition(World Health Organization 2021). 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