{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,16]],"date-time":"2026-06-16T06:28:28Z","timestamp":1781591308662,"version":"3.54.5"},"reference-count":62,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2025,7,10]],"date-time":"2025-07-10T00:00:00Z","timestamp":1752105600000},"content-version":"vor","delay-in-days":9,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2025,7,1]],"date-time":"2025-07-01T00:00:00Z","timestamp":1751328000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal of Medical Virology"],"published-print":{"date-parts":[[2025,7]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    Prolonged exposure to the High\u2010risk Human Papillomavirus (HPV) leads to the development of cervical carcinoma. Numerous factors aid in this virus's acquisition, persistence, and clearance. This study aims to determine the association of vaginal microbiota and socio\u2010demographic factors with oncogenic HPV infections among women from Eastern region of India. Cervical scrapes and vaginal swab samples were collected from women (\n                    <jats:italic>n<\/jats:italic>\n                    \u2009=\u2009300) having some gynecological complaints with informed consent. Cervical cytology and HPV types were screened among them. A subset of samples (\n                    <jats:italic>n<\/jats:italic>\n                    \u2009=\u200912) were subjected for next generation sequencing based 16S rRNA profiling to determine the vaginal bacterial diversity among the HPV\u2212positive and HPV\u2212negative women with normal cervical cytology. The taxonomic profiling, diversity and relative abundance of bacterial species were determined subsequently. With appropriate statistical tests, vaginal bacterial diversity along with socio\u2010demographic risk factors was correlated with HPV infections. A PCR\u2010based approach further detected the bacterial taxa that were exclusively present among the groups in the whole data set. HPV infection was identified among 11.60% of individuals, with the dominance of\n                    <jats:italic>HPV18<\/jats:italic>\n                    (80%) among carcinogenic HPV. 16S rRNA profiling revealed that the HPV\u2010positive group had lower abundance of Firmicutes phylum and higher abundance of Proteobacteria and Actinobacteria phyla than the HPV\u2010negative group. A positive correlation between Genus\n                    <jats:italic>Acinetobacter<\/jats:italic>\n                    and HPV positivity was established, presenting higher susceptibility for oncogenic\n                    <jats:italic>HPV16\/18<\/jats:italic>\n                    (\n                    <jats:italic>p<\/jats:italic>\n                    \u2009=\u20090.016; relative mean abundance\u2009=\u200919.67). PCR\u2010based detection of this genus in the whole data set (\n                    <jats:italic>n<\/jats:italic>\n                    \u2009=\u2009300), a statistically significant association with oncogenic\n                    <jats:italic>HPV16\/18<\/jats:italic>\n                    infection (\n                    <jats:italic>p<\/jats:italic>\n                    \u2009\u2264\u20090.01, odds ratio\u2009(OR)=\u200922.48 [95% CI\u2009=\u20095.23\u201396.63]) was found. Among sociodemographic factors, Tobacco users (16.67%, 4\/24; OR\u2009=\u20096.70 [95% CI: 1.86\u201324.18];\n                    <jats:italic>p<\/jats:italic>\n                    \u2009=\u20090.001) and field\u2010workers (15.79%, 3\/19; OR\u2009=\u20095.67 [95% CI: 1.40\u201322.99];\n                    <jats:italic>p<\/jats:italic>\n                    \u2009=\u20090.007) were associated with a higher risk of\n                    <jats:italic>HPV18<\/jats:italic>\n                    infections. Assessment of geography\u2010specific vaginal microbiota and other lifestyle induced risk factors might contribute to acquire chronic infection of oncogenic HPV and progression to cervical cancer.\n                  <\/jats:p>","DOI":"10.1002\/jmv.70472","type":"journal-article","created":{"date-parts":[[2025,7,10]],"date-time":"2025-07-10T11:15:37Z","timestamp":1752146137000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Association of Vaginal Microbiota and Sociodemographic Factors With Cervical Human Papillomavirus in the Eastern Region of India"],"prefix":"10.1002","volume":"97","author":[{"given":"Suvanjana","family":"Ghosh","sequence":"first","affiliation":[{"name":"Biomedical Genetics Laboratory, Department of Zoology The University of Burdwan Bardhaman India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anindita","family":"Goswami","sequence":"additional","affiliation":[{"name":"Biomedical Genetics Laboratory, Department of Zoology The University of Burdwan Bardhaman India"},{"name":"Department of Allied Health Sciences Adamas University Kolkata India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arghya","family":"Bandyopadhyay","sequence":"additional","affiliation":[{"name":"Department of Pathology Burdwan Medical College &amp; Hospital Bardhaman India"},{"name":"Department of Pathology NRS Medical College &amp; Hospital Kolkata India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Raju Gopal","family":"Saha","sequence":"additional","affiliation":[{"name":"Department of Obstetrics &amp; Gynaecology Burdwan Medical College &amp; Hospital Bardhaman India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0005-9229-6885","authenticated-orcid":false,"given":"Paramita","family":"Mandal","sequence":"additional","affiliation":[{"name":"Biomedical Genetics Laboratory, Department of Zoology The University of Burdwan Bardhaman India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,7,10]]},"reference":[{"key":"e_1_2_11_2_1","unstructured":"L.Bruni G.Albero andB.Serrano 2023ICO\/IARC Information Centre on HPV and Cancer (HPV Information Centre). Human Papillomavirus and Related Diseases in the World. Summary Report 10 March 2023."},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.3322\/caac.21834"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(07)61416-0"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.3390\/cancers13112691"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12879-016-2136-4"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.7314\/APJCP.2015.16.18.8187"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1525-1438.2007.00827.x"},{"key":"e_1_2_11_9_1","doi-asserted-by":"publisher","DOI":"10.22207\/JPAM.17.4.25"},{"key":"e_1_2_11_10_1","doi-asserted-by":"publisher","DOI":"10.1097\/PGP.0b013e3182399391"},{"key":"e_1_2_11_11_1","doi-asserted-by":"publisher","DOI":"10.1002\/jmv.27436"},{"key":"e_1_2_11_12_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0219173"},{"key":"e_1_2_11_13_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0063514"},{"key":"e_1_2_11_14_1","doi-asserted-by":"publisher","DOI":"10.1128\/CMR.16.1.1-17.2003"},{"key":"e_1_2_11_15_1","doi-asserted-by":"publisher","DOI":"10.1097\/00008469-200210000-00007"},{"key":"e_1_2_11_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(78)90750-X"},{"key":"e_1_2_11_17_1","doi-asserted-by":"publisher","DOI":"10.21147\/j.issn.1000-9604.2020.06.05"},{"key":"e_1_2_11_18_1","doi-asserted-by":"publisher","DOI":"10.1177\/17455065221075904"},{"key":"e_1_2_11_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.canep.2018.03.005"},{"key":"e_1_2_11_20_1","first-page":"1","article-title":"Human Papillomaviruses","volume":"90","author":"H.IARC Working Group on the Evaluation of Carcinogenic Risks to Humans","year":"2007","journal-title":"IARC Monographs on the Evaluation of Carcinogenic Risks to Humans"},{"key":"e_1_2_11_21_1","doi-asserted-by":"publisher","DOI":"10.1159\/000511477"},{"key":"e_1_2_11_22_1","doi-asserted-by":"publisher","DOI":"10.18332\/tid\/140093"},{"key":"e_1_2_11_23_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00384-014-1922-y"},{"key":"e_1_2_11_24_1","doi-asserted-by":"publisher","DOI":"10.1038\/srep16865"},{"key":"e_1_2_11_25_1","doi-asserted-by":"publisher","DOI":"10.1186\/s40168-016-0203-0"},{"issue":"11","key":"e_1_2_11_26_1","first-page":"21080","article-title":"Characteristics of Bacterial Vaginosis Infection in Cervical Lesions With High Risk Human Papillomavirus Infection","volume":"8","author":"Lu H.","year":"2015","journal-title":"International Journal of Clinical and Experimental Medicine"},{"issue":"6","key":"e_1_2_11_27_1","first-page":"7035","article-title":"Microbiota Dysbiosis Is Associated With HPV\u2010Induced Cervical Carcinogenesis","volume":"16","author":"Kwasniewski W.","year":"2018","journal-title":"Oncology Letters"},{"key":"e_1_2_11_28_1","doi-asserted-by":"publisher","DOI":"10.1111\/1471-0528.15854"},{"key":"e_1_2_11_29_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-017-09842-6"},{"key":"e_1_2_11_30_1","first-page":"1","article-title":"Comparative Analysis of Vaginal Microbiome Associated With Oncogenic HPV Infection Among Different Ethnic Groups of Women of the Eastern Region of India","author":"Goswami A.","year":"2024","journal-title":"Indian Journal of Microbiology"},{"key":"e_1_2_11_31_1","doi-asserted-by":"publisher","DOI":"10.1099\/mic.0.026054-0"},{"key":"e_1_2_11_32_1","doi-asserted-by":"publisher","DOI":"10.4103\/0971-5851.96961"},{"key":"e_1_2_11_33_1","doi-asserted-by":"publisher","DOI":"10.4103\/0971-5851.92808"},{"key":"e_1_2_11_34_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ypmed.2016.12.030"},{"key":"e_1_2_11_35_1","unstructured":"L.Bruni G.Albero B.Serrano et al. ICO\/IARC Information Centre on HPV and Cancer (HPV Information Centre). Human Papillomavirus and Related Diseases in [India]. Summary Report 22 October 2021."},{"issue":"1","key":"e_1_2_11_36_1","first-page":"27","article-title":"Study on the Effect of Socio\u2010Demographic Parameters on Disease Prevalence Among Tribal Communities in West Bengal","volume":"17","author":"Goswami A.","year":"2019","journal-title":"India Studies of Tribes and Tribals"},{"key":"e_1_2_11_37_1","doi-asserted-by":"publisher","DOI":"10.18203\/2320-1770.ijrcog20190971"},{"key":"e_1_2_11_38_1","doi-asserted-by":"publisher","DOI":"10.4103\/ijmr.IJMR_2023_17"},{"key":"e_1_2_11_39_1","doi-asserted-by":"publisher","DOI":"10.1200\/jgo.18.41100"},{"key":"e_1_2_11_40_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10552-008-9230-x"},{"key":"e_1_2_11_41_1","doi-asserted-by":"publisher","DOI":"10.4103\/0976-7800.191012"},{"key":"e_1_2_11_42_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijgo.2004.07.013"},{"key":"e_1_2_11_43_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-019-50410-x"},{"key":"e_1_2_11_44_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.micpath.2020.104617"},{"key":"e_1_2_11_45_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13104-020-05422-6"},{"key":"e_1_2_11_46_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12967-024-04916-2"},{"key":"e_1_2_11_47_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMra070741"},{"key":"e_1_2_11_48_1","doi-asserted-by":"publisher","DOI":"10.3389\/fonc.2019.00608"},{"key":"e_1_2_11_49_1","doi-asserted-by":"publisher","DOI":"10.1038\/s42003-021-02557-5"},{"key":"e_1_2_11_50_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-023-32809-9"},{"key":"e_1_2_11_51_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41419-021-04396-y"},{"key":"e_1_2_11_52_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2020.02184"},{"key":"e_1_2_11_53_1","doi-asserted-by":"publisher","DOI":"10.1128\/CMR.00058-16"},{"key":"e_1_2_11_54_1","doi-asserted-by":"publisher","DOI":"10.15620\/cdc:82532"},{"key":"e_1_2_11_55_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.lanmic.2024.07.003"},{"key":"e_1_2_11_56_1","doi-asserted-by":"publisher","DOI":"10.4103\/jcrt.JCRT_737_17"},{"key":"e_1_2_11_57_1","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2180-8-216"},{"key":"e_1_2_11_58_1","doi-asserted-by":"publisher","DOI":"10.1136\/ijgc-2018-000032"},{"key":"e_1_2_11_59_1","doi-asserted-by":"publisher","DOI":"10.1002\/jmv.29451"},{"key":"e_1_2_11_60_1","doi-asserted-by":"publisher","DOI":"10.1002\/cam4.70440"},{"key":"e_1_2_11_61_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12905-025-03599-1"},{"key":"e_1_2_11_62_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12905-023-02504-y"},{"key":"e_1_2_11_63_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.bjc.6602348"}],"container-title":["Journal of Medical Virology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/jmv.70472","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/jmv.70472","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/jmv.70472","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,29]],"date-time":"2026-05-29T13:52:07Z","timestamp":1780062727000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/jmv.70472"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,7]]},"references-count":62,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2025,7]]}},"alternative-id":["10.1002\/jmv.70472"],"URL":"https:\/\/doi.org\/10.1002\/jmv.70472","archive":["Portico"],"relation":{},"ISSN":["0146-6615","1096-9071"],"issn-type":[{"value":"0146-6615","type":"print"},{"value":"1096-9071","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,7]]},"assertion":[{"value":"2025-02-05","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-06-18","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-07-10","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e70472"}}