{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,25]],"date-time":"2026-06-25T21:32:11Z","timestamp":1782423131238,"version":"3.54.5"},"reference-count":33,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2025,6,30]],"date-time":"2025-06-30T00:00:00Z","timestamp":1751241600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2025,6,30]],"date-time":"2025-06-30T00:00:00Z","timestamp":1751241600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal of Medical Virology"],"published-print":{"date-parts":[[2025,7]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    Torque teno virus (TTV) DNA load in plasma is suggested as a marker for immunosuppression post\u2010transplantation. Crohn's disease (CD) arises from genetic susceptibility, environmental factors, and dysbiosis, causing immune responses. This study examines TTV DNA load in CD patients in remission and its correlation with relapse. Using quantitative real\u2010time polymerase chain reaction (PCR) and metagenomic analysis, the dynamic of plasma TTV DNA load was analyzed from a cohort of CD patients (\n                    <jats:italic>n<\/jats:italic>\n                    \u2009=\u200939) over 1 year and compared with controls (\n                    <jats:italic>n<\/jats:italic>\n                    \u2009=\u200949). At inclusion, TTV DNA was significantly higher in CD patients compare to control (Median [IQR]: 3.27 [2.43\u20133.67] and 2.05 [1.28\u20132.80] Log copies\/mL,\n                    <jats:italic>p<\/jats:italic>\n                    \u2009=\u20090.0004). Plasma TTV DNA load failed to predict disease relapse in CD patients. Augmented plasma TTV DNA levels in CD patients correlated with diminished circulating CD3\u2009+\u2009T cells and especially CD4\u2009+\u2009T cells. No preferential representation of TTV subspecies or Anelloviridae genera was detected in CD patients' plasma. This study revealed elevated TTV DNA levels in CD patients' plasma compared to healthy controls, underscoring the intriguing potential of TTV blood sampling as a biomarker in CD.\n                  <\/jats:p>","DOI":"10.1002\/jmv.70473","type":"journal-article","created":{"date-parts":[[2025,6,30]],"date-time":"2025-06-30T09:39:19Z","timestamp":1751276359000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Deep Characterisation of Circulating Torque Teno Virus DNA Load in Crohn's Disease Patients"],"prefix":"10.1002","volume":"97","author":[{"given":"Margaux","family":"Goens","sequence":"first","affiliation":[{"name":"Service de Gastroent\u00e9rologie, h\u00e9patologie et nutrition p\u00e9diatriques, Centre constitutif des maladies Rare Digestives, Hospices Civils de Lyon, Femme M\u00e8re\u2010Enfant\u2010Hospital Bron France"},{"name":"Joint Research Unit, Hospices Civils de Lyon\u2010bioM\u00e9rieux, H\u00f4pital Lyon Sud Pierre\u2010B\u00e9nite France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8455-0952","authenticated-orcid":false,"given":"William","family":"Mouton","sequence":"additional","affiliation":[{"name":"Joint Research Unit, Hospices Civils de Lyon\u2010bioM\u00e9rieux, H\u00f4pital Lyon Sud Pierre\u2010B\u00e9nite France"},{"name":"Centre international de recherche en infectiologie (CIRI) Universit\u00e9 de Lyon, Inserm U1111, Universit\u00e9 Claude Bernard Lyon 1, CNRS UMR5308, \u00c9cole normale sup\u00e9rieure de Lyon Lyon France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guy","family":"Oriol","sequence":"additional","affiliation":[{"name":"Joint Research Unit, Hospices Civils de Lyon\u2010bioM\u00e9rieux, H\u00f4pital Lyon Sud Pierre\u2010B\u00e9nite 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