{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T20:00:37Z","timestamp":1790193637208,"version":"4.1.0"},"reference-count":31,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2025,7,7]],"date-time":"2025-07-07T00:00:00Z","timestamp":1751846400000},"content-version":"vor","delay-in-days":6,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2025,7,1]],"date-time":"2025-07-01T00:00:00Z","timestamp":1751328000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal of Medical Virology"],"published-print":{"date-parts":[[2025,7]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>Despite causative links to lymphoproliferative disorders, little is known about early events governing KSHV infection in B lymphocytes. IL\u20106 signaling plays a critical role in KSHV\u2010mediated disease, with human IL\u20106 (hIL6) levels correlating with viral load and disease progression. This dynamic is even more complex due to the coexistence of hIL6 and KSHV\u2010encoded viral IL\u20106 (vIL6) in these diseases. We hypothesize that hIL6 and vIL6 play critical, separable and collective roles in the early stages of KSHV infection in B cells. In this study, we use our ex vivo model of KSHV infection in human tonsil lymphocytes to investigate the relative contributions of vIL6 and hIL6 to early infection events in human B cells. We demonstrate that vIL6 and hIL6 collectively suppress KSHV infection in B cells restricting the distribution of KSHV within B cell subsets. We show that vIL6 manipulates hIL6 expression in a subset\u2010specific manner, and that vIL6 and hIL6 differentially influence the differentiation of germinal center and plasmablasts. Taken together, these results suggest a novel paradigm in which KSHV uses vIL6 to abrogate the GC\u2010mediated maturation pathway for antibody secreting cells that is driven by hIL6 signaling.<\/jats:p>","DOI":"10.1002\/jmv.70479","type":"journal-article","created":{"date-parts":[[2025,7,7]],"date-time":"2025-07-07T11:35:34Z","timestamp":1751888134000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["KSHV vIL6 Inhibits Functional B Cell Maturation During De Novo Infection"],"prefix":"10.1002","volume":"97","author":[{"given":"Wajd","family":"Zakir","sequence":"first","affiliation":[{"name":"Biomedical and Pharmaceutical Sciences Chapman University School of Pharmacy Irvine California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jessica M.","family":"Osborn","sequence":"additional","affiliation":[{"name":"Department of Family Medicine Oregon Health and Science University Portland Oregon USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8444-8536","authenticated-orcid":false,"given":"Jennifer E.","family":"Totonchy","sequence":"additional","affiliation":[{"name":"Biomedical and Pharmaceutical Sciences Chapman University School of Pharmacy Irvine California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,7,7]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12275-017-7075-2"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.ppat.1008968"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2022.1010274"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.3390\/v14102295"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.3390\/v13081512"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.3389\/fcimb.2020.607663"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41584-020-0419-z"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.02723-09"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.01192-15"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1038\/nm0397-287"},{"key":"e_1_2_9_12_1","unstructured":"Molecular Mimicry of Human Cytokine and Cytokine Response Pathway Genes by KSHV | Science [Internet]. 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