{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,29]],"date-time":"2026-05-29T14:12:58Z","timestamp":1780063978147,"version":"3.54.0"},"reference-count":36,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2025,7,10]],"date-time":"2025-07-10T00:00:00Z","timestamp":1752105600000},"content-version":"vor","delay-in-days":9,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2025,7,1]],"date-time":"2025-07-01T00:00:00Z","timestamp":1751328000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal of Medical Virology"],"published-print":{"date-parts":[[2025,7]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>Cytomegalovirus encephalitis (CMVE) is a rare but severe complication following hematopoietic stem cell transplantation (HSCT). However, a comprehensive investigation of its clinical characteristics and potential risk factors remains limited. Our study aims to characterize the clinical features of CMVE patients after HSCT and further explore the risk factors for its incidence. We performed a retrospective nested case\u2010control study on 13 CMVE patients and 52 cases of age\u2010 and gender\u2010matched controls by a ratio of 1:4. Clinical data and lab parameters were collected and analyzed. A total of 21 pre\u2010 and posttransplantation factors were selected and analyzed by logistic regression for risk factor exploration. Our results show the median age of CMVE patients was 35 years, and the median time from HSCT to diagnosis of CMVE was 134 days. Eight patients (62%) were diagnosed with CMV viremia and five patients (38.5%) presented with EBV infections prior to the diagnosis of CMVE. The most common manifestations were altered consciousness and nausea\/vomiting. Imaging findings showed lesions primarily located in the basal ganglia and centrum semiovale. Most of patients had elevated protein and glucose levels in cerebrospinal fluid (CSF). Multivariate logistic regression analysis further showed that posttransplant EBV infection was associated with an increased risk of CMVE. Additionally, patients with medium reconstitution of CD4+CD28+ T cells or high reconstitution were associated with a reduced risk of CMVE compared with poor reconstitution patients. Our findings highlighted the necessity of EBV loads and CD4+CD28+ T cells construction monitoring after HSCT to be alert to the occurrence of CMVE and immediate clinical diagnosis and treatment.<\/jats:p>","DOI":"10.1002\/jmv.70489","type":"journal-article","created":{"date-parts":[[2025,7,10]],"date-time":"2025-07-10T11:37:26Z","timestamp":1752147446000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Epstein\u2013Barr Virus Infection and CD4+CD28+ T Cells Immune Construction Status Were Associated With the Incidence of Cytomegalovirus Encephalitis in Patients After Hematopoietic Stem Cell Transplantation"],"prefix":"10.1002","volume":"97","author":[{"ORCID":"https:\/\/orcid.org\/0009-0001-0670-4186","authenticated-orcid":false,"given":"Rui","family":"Ma","sequence":"first","affiliation":[{"name":"Department of Clinical Laboratory Peking University People's Hospital Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jing\u2010hong","family":"Feng","sequence":"additional","affiliation":[{"name":"Department of Clinical Laboratory Peking University People's Hospital Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wen\u2010yi","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Clinical Laboratory Peking University People's Hospital Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yan","family":"Long","sequence":"additional","affiliation":[{"name":"Department of Clinical Laboratory Peking University People's Hospital Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,7,10]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jns.2018.02.029"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood.2019000956"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.2217\/fmb-2017-0095"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41579-021-00582-z"},{"issue":"1","key":"e_1_2_10_6_1","first-page":"78","article-title":"Risk Factors for the Development of Cytomegalovirus Disease After Allogeneic Stem Cell Transplantation","volume":"91","author":"Ljungman P.","year":"2006","journal-title":"Haematologica"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1155\/2012\/375075"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41409-023-02151-9"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1038\/bmt.2015.306"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cmi.2015.06.009"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00277-020-04201-4"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1093\/cid\/ciw668"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11684-017-0548-1"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcv.2021.104936"},{"issue":"2","key":"e_1_2_10_15_1","first-page":"513","article-title":"[Clinical Study of Cytomegalovirus Infection After Allogeneic Hematopoietic Stem Cell Transplantation]","volume":"31","author":"Xiong Y. Y.","year":"2023","journal-title":"Zhongguo Shi Yan Xue Ye Xue Za Zhi"},{"key":"e_1_2_10_16_1","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.00403-07"},{"key":"e_1_2_10_17_1","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.77.8.4588-4596.2003"},{"key":"e_1_2_10_18_1","doi-asserted-by":"publisher","DOI":"10.1136\/jitc-2023-008375"},{"key":"e_1_2_10_19_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.140.6.1753"},{"key":"e_1_2_10_20_1","doi-asserted-by":"publisher","DOI":"10.1128\/MCB.01869-08"},{"key":"e_1_2_10_21_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.0800455"},{"key":"e_1_2_10_22_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2023.1139517"},{"key":"e_1_2_10_23_1","doi-asserted-by":"publisher","DOI":"10.3324\/haematol.2014.113415"},{"key":"e_1_2_10_24_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2025.1464096"},{"key":"e_1_2_10_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.hemonc.2017.05.001"},{"key":"e_1_2_10_26_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13287-020-01615-9"},{"key":"e_1_2_10_27_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2015-01-622837"},{"key":"e_1_2_10_28_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.retram.2019.01.001"},{"key":"e_1_2_10_29_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcyt.2020.01.005"},{"key":"e_1_2_10_30_1","doi-asserted-by":"publisher","DOI":"10.1093\/cei\/uxac047"},{"key":"e_1_2_10_31_1","doi-asserted-by":"publisher","DOI":"10.1093\/labmed\/lmz030"},{"key":"e_1_2_10_32_1","doi-asserted-by":"publisher","DOI":"10.1111\/1469-0691.12120"},{"issue":"8","key":"e_1_2_10_33_1","first-page":"651","article-title":"[Prevalence of EBV Infection in Patients With Allogeneic Hematopoietic Stem Cell Transplantation]","volume":"34","author":"Han T. T.","year":"2013","journal-title":"Zhonghua Xue Ye Xue Za Zhi"},{"key":"e_1_2_10_34_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.bmt.1705585"},{"key":"e_1_2_10_35_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.humimm.2004.02.022"},{"key":"e_1_2_10_36_1","doi-asserted-by":"publisher","DOI":"10.1136\/bcr-2022-249902"},{"key":"e_1_2_10_37_1","doi-asserted-by":"publisher","DOI":"10.1007\/s40475-022-00255-8"}],"container-title":["Journal of Medical Virology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/jmv.70489","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/jmv.70489","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/jmv.70489","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,29]],"date-time":"2026-05-29T13:51:05Z","timestamp":1780062665000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/jmv.70489"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,7]]},"references-count":36,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2025,7]]}},"alternative-id":["10.1002\/jmv.70489"],"URL":"https:\/\/doi.org\/10.1002\/jmv.70489","archive":["Portico"],"relation":{},"ISSN":["0146-6615","1096-9071"],"issn-type":[{"value":"0146-6615","type":"print"},{"value":"1096-9071","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,7]]},"assertion":[{"value":"2025-03-15","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-06-24","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-07-10","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e70489"}}