{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,29]],"date-time":"2026-05-29T14:15:13Z","timestamp":1780064113737,"version":"3.54.0"},"reference-count":42,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2025,7,16]],"date-time":"2025-07-16T00:00:00Z","timestamp":1752624000000},"content-version":"vor","delay-in-days":15,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2025,7,1]],"date-time":"2025-07-01T00:00:00Z","timestamp":1751328000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal of Medical Virology"],"published-print":{"date-parts":[[2025,7]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>Nirmatrelvir\/ritonavir (NMV\u2010r) is an oral antiviral agent authorized for treating acute COVID\u201019, but its effectiveness in reducing long COVID risk remains uncertain. This multicenter retrospective cohort study aimed to evaluate the association between NMV\u2010r and the risk of long COVID. Electronic health record data from the TriNetX US Collaborative Network were used. Adults aged \u2265\u200918 years with a positive COVID\u201019 test between January 1, 2022 and June 30, 2024 were included. NMV\u2010r users were those who received NMV\u2010r within 5 days of testing positive, while those who did not receive NMV\u2010r within this period were the nonusers. The outcome was time to the first diagnosis of incident post\u2010COVID conditions, including general, pulmonary, cardiac, thromboembolic, neurologic, mental, musculoskeletal, gastrointestinal, and kidney symptoms. Propensity score matching was performed to balance baseline characteristics and Cox proportional hazards models were used to estimate the risk of long COVID between NMV\u2010r users and nonusers. Both groups included 218\u2009825 patients after matching. Overall, the risk of long COVID was similar between NMV\u2010r users and nonusers (HR, 0.99; 95% CI, 0.98\u20131.01). Symptom\u2010specific analyses revealed mixed effects, with NMV\u2010r use associated with an increased risk of cough and sleeping disorders but a decreased risk for other long COVID symptoms. Sensitivity analyses showed consistent results with the main analysis. In conclusion, NMV\u2010r use was not associated with a reduced risk of long COVID. Future research is needed to explore its heterogeneous effects on post\u2010COVID conditions.<\/jats:p>","DOI":"10.1002\/jmv.70494","type":"journal-article","created":{"date-parts":[[2025,7,17]],"date-time":"2025-07-17T04:15:51Z","timestamp":1752725751000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Association of Nirmatrelvir\/Ritonavir and the Risk of Long COVID Among US Adults: A Multicenter Retrospective Cohort Study"],"prefix":"10.1002","volume":"97","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3485-9775","authenticated-orcid":false,"given":"Chun\u2010Tse","family":"Hung","sequence":"first","affiliation":[{"name":"School of Pharmacy, College of Pharmacy Taipei Medical University Taipei Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Li\u2010Min","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Pharmacy Taipei Medical University Hospital Taipei Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuarn\u2010Jang","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Division of Infectious Diseases, Shuang Ho Hospital Taipei Medical University Taipei Taiwan"},{"name":"Department of Internal Medicine, School of Medicine, Division of Infectious Diseases, College of Medicine Taipei Medical University Taipei Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chi\u2010Won","family":"Suk","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Division of Pulmonary Medicine, Taipei Municipal Wan Fang Hospital Taipei Medical University Taipei Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chin\u2010Yee","family":"Kok","sequence":"additional","affiliation":[{"name":"School of Pharmacy, College of Pharmacy Taipei Medical University Taipei Taiwan"},{"name":"Department of Pharmacy Taipei Medical University Hospital Taipei Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,7,16]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMsb2408466"},{"key":"e_1_2_11_3_1","doi-asserted-by":"crossref","unstructured":"N. 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