{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,29]],"date-time":"2026-05-29T14:13:06Z","timestamp":1780063986442,"version":"3.54.0"},"reference-count":20,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2025,7,18]],"date-time":"2025-07-18T00:00:00Z","timestamp":1752796800000},"content-version":"vor","delay-in-days":17,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2025,7,1]],"date-time":"2025-07-01T00:00:00Z","timestamp":1751328000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal of Medical Virology"],"published-print":{"date-parts":[[2025,7]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    <jats:italic>Orthohantavirus puumalaense<\/jats:italic>\n                    causes hemorrhagic fever with renal syndrome in Europe, with Puumala virus (PUUV) as its primary representative. Muju virus (MUJV), harbored by\n                    <jats:italic>Craseomys regulus<\/jats:italic>\n                    , an Arvicolinae rodent species endemic to the Republic of Korea (ROK), is also a genotype of\n                    <jats:italic>O. puumalaense<\/jats:italic>\n                    . However, their genomic diversity and zoonotic potential remain largely unknown. To investigate their prevalence, 185 voles were collected from 23 regions of the ROK between 2012 and 2023. Serological assays detected anti\u2010PUUV immunoglobulin G antibodies in five samples (3.1%), whereas reverse\u2010transcription polymerase chain reaction confirmed MUJV RNA in identical specimens (2.7%). Amplicon\u2010based nanopore sequencing facilitates near\u2010complete genome recovery, enabling high\u2010resolution comparative analysis. Phylogenetic analysis revealed distinct genetic lineages in Gangwon and Jeollabuk Provinces. Evolutionary rate estimates indicated greater sequence divergence in the S and L segments than in the M segment. A zoonotic risk assessment revealed that most MUJV variants exhibited moderate\u2010to\u2010high spillover potential. The molecular detection of MUJV in Cheorwon, Gangwon Province, expands its known geographic range and provides the first molecular evidence of MUJV circulation in this region. These findings highlight the need for continued surveillance and seroprevalence studies of MUJV to assess its potential for human exposure and public health relevance in the ROK.\n                  <\/jats:p>","DOI":"10.1002\/jmv.70503","type":"journal-article","created":{"date-parts":[[2025,7,18]],"date-time":"2025-07-18T07:52:45Z","timestamp":1752825165000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Molecular Evolution and Zoonotic Potential of Muju Virus (\n                    <i>Orthohantavirus puumalaense<\/i>\n                    ) in\n                    <i>Craseomys regulus<\/i>\n                    , Republic of Korea"],"prefix":"10.1002","volume":"97","author":[{"given":"Kyungmin","family":"Park","sequence":"first","affiliation":[{"name":"Department of Microbiology Korea University College of Medicine Seoul Republic of Korea"},{"name":"Institute for Viral Diseases Korea University College of Medicine Seoul Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Seong\u2010Gyu","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Microbiology Korea University College of Medicine Seoul Republic of Korea"},{"name":"BK21 Graduate Program, Department of Biomedical Sciences Korea University College of Medicine Seoul Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeong\u2010Ah","family":"Kim","sequence":"additional","affiliation":[{"name":"Division of Emerging Infectious Diseases Bureau of Infectious Diseases Diagnosis Control, Korea Disease Control and Prevention Agency Cheongju Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sara P.","family":"Prayitno","sequence":"additional","affiliation":[{"name":"Department of Microbiology, College of Medicine Hallym University Chuncheon Republic of 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