{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,2]],"date-time":"2026-10-02T22:33:38Z","timestamp":1790980418229,"version":"4.1.0"},"reference-count":44,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2025,7,25]],"date-time":"2025-07-25T00:00:00Z","timestamp":1753401600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2025,7,25]],"date-time":"2025-07-25T00:00:00Z","timestamp":1753401600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100003196","name":"Ministero della Salute","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003196","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal of Medical Virology"],"published-print":{"date-parts":[[2025,8]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    This study investigates the prevalence of beta (\u03b2) and gamma (\u03b3) human papillomavirus (HPV) types in cervical and anal samples from women living with HIV and examines their association with alpha (\u03b1) HPV and cytological lesions. Cervical and anal swabs were collected from 138 women. Detection of \u03b2\u2010 and \u03b3\u2010HPV types were performed using bead\u2010based assays, and data analysis included only samples with adequate DNA quality, as confirmed by \u03b2\u2010globin amplification. The analysis revealed higher rates of \u03b2\u2010HPV in anal samples (51.7%) compared to cervical samples (30.3%), with \u03b2\u20101 species being predominant in both sites. Furthermore, \u03b3\u2010HPV types were more prevalent in anal samples (36.5%) than in cervical site (16.9%), with \u03b3\u201010 being the most frequently detected species. Concordance between cervical and anal samples for specific \u03b2\u2010HPV types (\u03ba\u2009=\u20090.20, 95% CI: 0.03\u20130.36) and \u03b3\u2010HPV types (\u03ba\u2009=\u20090.17, 95% CI: 0.003\u20130.36) was poor. Co\u2010infections with both \u03b2\u2010 and \u03b3\u2010HPV types in cervical samples was significantly associated with co\u2010infection at the anal site (OR 7.7; 95% CI: 1.44\u201338.25;\n                    <jats:italic>p<\/jats:italic>\n                    \u2009=\u20090.01). There was no statistically significant association (\n                    <jats:italic>p<\/jats:italic>\n                    \u2009&gt;\u20090.05) between \u03b2\u2010HPV positivity and neoplastic precancerous lesions (LSIL or HSIL) at either the cervical or anal site. Similarly, \u03b3\u2010HPV positivity showed no significant association (\n                    <jats:italic>p<\/jats:italic>\n                    \u2009&gt;\u20090.05) with cytological abnormalities in cervical or anal samples. In conclusion, while the prevalence of \u03b2\u2010 and \u03b3\u2010HPV types is higher in the anal region among HIV\u2010positive women, the absence of a strong association with neoplastic lesions underscores their limited oncogenic potential compared to high\u2010risk \u03b1\u2010HPV types.\n                  <\/jats:p>","DOI":"10.1002\/jmv.70518","type":"journal-article","created":{"date-parts":[[2025,7,25]],"date-time":"2025-07-25T07:05:02Z","timestamp":1753427102000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Co\u2010Infection Patterns of Beta, Gamma, and Alpha HPV Types in Cervical and Anal Sites in HIV\u2010Positive Women"],"prefix":"10.1002","volume":"97","author":[{"given":"Verdiana","family":"Zulian","sequence":"first","affiliation":[{"name":"Laboratory of Virology National Institute for Infectious Diseases \u201cLazzaro Spallanzani\u201d (IRCCS) Rome Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Silvia","family":"Pauciullo","sequence":"additional","affiliation":[{"name":"Laboratory of Virology National Institute for Infectious Diseases \u201cLazzaro Spallanzani\u201d (IRCCS) Rome Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniele","family":"Colombo","sequence":"additional","affiliation":[{"name":"Pathology Unit National Institute for Infectious Diseases \u201cLazzaro Spallanzani\u201d (IRCCS) Rome Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sandrine","family":"McKay\u2010Chopin","sequence":"additional","affiliation":[{"name":"Epigenomics and Mechanisms Branch International Agency for Research on Cancer (IARC) Lyon France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Catia","family":"Sias","sequence":"additional","affiliation":[{"name":"Laboratory of Virology National Institute for Infectious Diseases \u201cLazzaro Spallanzani\u201d (IRCCS) Rome Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Franca","family":"Del Nonno","sequence":"additional","affiliation":[{"name":"Pathology Unit National Institute for Infectious Diseases \u201cLazzaro Spallanzani\u201d (IRCCS) Rome Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alessandra","family":"Scarabello","sequence":"additional","affiliation":[{"name":"Clinical and Research Infectious Diseases Department National Institute for Infectious Diseases \u201cLazzaro Spallanzani\u201d (IRCCS) Rome Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anna Rosa","family":"Garbuglia","sequence":"additional","affiliation":[{"name":"Laboratory of Virology National Institute for Infectious Diseases \u201cLazzaro Spallanzani\u201d (IRCCS) Rome Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tarik","family":"Gheit","sequence":"additional","affiliation":[{"name":"Epigenomics and Mechanisms Branch International Agency for Research on Cancer (IARC) Lyon France"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,7,25]]},"reference":[{"key":"e_1_2_11_2_1","unstructured":"WHO World Health Organization. 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