{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,12]],"date-time":"2026-07-12T05:07:42Z","timestamp":1783832862332,"version":"3.55.0"},"reference-count":62,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2025,8,16]],"date-time":"2025-08-16T00:00:00Z","timestamp":1755302400000},"content-version":"vor","delay-in-days":15,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2025,8,1]],"date-time":"2025-08-01T00:00:00Z","timestamp":1754006400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal of Medical Virology"],"published-print":{"date-parts":[[2025,8]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>The coronavirus disease 2019 (COVID\u201019) pandemic has triggered a global health crisis, with over 700 million confirmed cases and at least 7 million deaths reported by early 2024. Children are less vulnerable to severe SARS\u2010CoV\u20102 infection than adults and typically experience milder respiratory symptoms. However, a rare but significant complication, known as multisystem inflammatory syndrome in children (MIS\u2010C), can develop weeks after infection, characterized by a spectrum of inflammatory symptoms. This study employed whole\u2010exome sequencing and over\u2010representation analysis to identify genetic variants of potential clinical significance related to MIS\u2010C or severe COVID\u201019 in a group of children with acute respiratory distress syndrome (ARDS), all of whom were unvaccinated for COVID\u201019. We observed the enrichment of potentially pathogenic genetic variants in genes related to carbohydrate metabolism, particularly glycogen breakdown, in severe COVID\u201019 pediatric patients, and in genes related to cholesterol and lipoprotein metabolism in MIS\u2010C patients. These findings offer insights into the genetic underpinnings of MIS\u2010C and severe COVID\u201019, suggesting potential genes and biological pathways for further research.<\/jats:p>","DOI":"10.1002\/jmv.70556","type":"journal-article","created":{"date-parts":[[2025,8,16]],"date-time":"2025-08-16T13:01:48Z","timestamp":1755349308000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Genetic Variants Affect Distinct Metabolic Pathways in Pediatric Multisystem Inflammatory Syndrome and Severe COVID\u201019"],"prefix":"10.1002","volume":"97","author":[{"given":"Alysson Henrique","family":"Urbanski","sequence":"first","affiliation":[{"name":"Instituto Carlos Chagas FIOCRUZ Curitiba Paran\u00e1 Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fl\u00e1via Cristina de Paula","family":"Freitas","sequence":"additional","affiliation":[{"name":"Instituto Carlos Chagas FIOCRUZ Curitiba Paran\u00e1 Brazil"},{"name":"Universidade Federal de S\u00e3o Carlos S\u00e3o Carlos S\u00e3o Paulo Brazil"},{"name":"Departamento de Bioqu\u00edmica e Biologia Tecidual, Instituto de Biologia Universidade Estadual de Campinas Campinas S\u00e3o Paulo Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tiago Minuzzi Freire da Fontoura","family":"Gomes","sequence":"additional","affiliation":[{"name":"Instituto Carlos Chagas FIOCRUZ Curitiba Paran\u00e1 Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michelle Orane","family":"Schemberger","sequence":"additional","affiliation":[{"name":"Instituto Carlos Chagas FIOCRUZ Curitiba Paran\u00e1 Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"B\u00e1rbara Carvalho Santos dos","family":"Reis","sequence":"additional","affiliation":[{"name":"Laborat\u00f3rio de Alta Complexidade (LACIFF), Unidade de Pesquisa Cl\u00ednica, Instituto Fernandes Figueira FIOCRUZ  Rio de Janeiro Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Flavia Am\u00eandola An\u00edsio de","family":"Carvalho","sequence":"additional","affiliation":[{"name":"Laborat\u00f3rio de Alta Complexidade (LACIFF), Unidade de Pesquisa Cl\u00ednica, Instituto Fernandes Figueira FIOCRUZ  Rio de Janeiro Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roberta Soares","family":"Faccion","sequence":"additional","affiliation":[{"name":"Laborat\u00f3rio de Alta Complexidade (LACIFF), Unidade de Pesquisa Cl\u00ednica, Instituto Fernandes Figueira FIOCRUZ  Rio de Janeiro Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lucas de Almeida","family":"Machado","sequence":"additional","affiliation":[{"name":"Laborat\u00f3rio de Alta Complexidade (LACIFF), Unidade de Pesquisa Cl\u00ednica, Instituto Fernandes Figueira FIOCRUZ  Rio de Janeiro Brazil"},{"name":"Laborat\u00f3rio de Gen\u00f4mica Aplicada e Bioinova\u00e7\u00f5es (IOC), Instituto Oswaldo Cruz FIOCRUZ Rio de Janeiro Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Deborah Antunes dos","family":"Santos","sequence":"additional","affiliation":[{"name":"Laborat\u00f3rio de Gen\u00f4mica Aplicada e Bioinova\u00e7\u00f5es (IOC), Instituto Oswaldo Cruz FIOCRUZ Rio de Janeiro Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniela Prado","family":"Cunha","sequence":"additional","affiliation":[{"name":"Laborat\u00f3rio de Alta Complexidade (LACIFF), Unidade de Pesquisa Cl\u00ednica, Instituto Fernandes Figueira FIOCRUZ  Rio de Janeiro Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Margarida dos Santos","family":"Sal\u00fa","sequence":"additional","affiliation":[{"name":"Laborat\u00f3rio de Alta Complexidade (LACIFF), Unidade de Pesquisa Cl\u00ednica, Instituto Fernandes Figueira FIOCRUZ  Rio de Janeiro Brazil"},{"name":"Programa de P\u00f3s\u2010gradua\u00e7\u00e3o em Pesquisa Aplicada \u00e0 Sa\u00fade da Crian\u00e7a e da Mulher, Instituto Nacional de Sa\u00fade da Mulher da Crian\u00e7a e do Adolescente Fernandes Figueira (IFF), FIOCRUZ  Rio de Janeiro Brazil"},{"name":"Pediatric Intensive Care Unit Hospital Martag\u00e3o Gesteira Salvador Bahia Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniella Campelo Batalha Cox","family":"Moore","sequence":"additional","affiliation":[{"name":"Departamento de Pediatria, IFF Unidade de Pacientes Graves FIOCRUZ Rio de Janeiro RJ Brazil"},{"name":"Faculdade de Medicina Universidade Federal Fluminense Niter\u00f3i Rio de Janeiro RJ Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mayra Marinho","family":"Presibella","sequence":"additional","affiliation":[{"name":"Laborat\u00f3rio Central do Estado do Paran\u00e1 (LACEN) S\u00e3o Jos\u00e9 dos Pinhais Paran\u00e1 Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9128-8796","authenticated-orcid":false,"given":"Juliana Fontes","family":"Noguchi","sequence":"additional","affiliation":[{"name":"Faculdade Evang\u00e9lica Mackenzie Do Paran\u00e1 Curitiba Paran\u00e1 Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Henrique Lira","family":"Borges","sequence":"additional","affiliation":[{"name":"Faculdade Evang\u00e9lica Mackenzie Do Paran\u00e1 Curitiba Paran\u00e1 Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lais Kimie","family":"Tomiura","sequence":"additional","affiliation":[{"name":"Faculdade Evang\u00e9lica Mackenzie Do Paran\u00e1 Curitiba Paran\u00e1 Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luiza","family":"Silva de Castro","sequence":"additional","affiliation":[{"name":"Faculdade Evang\u00e9lica Mackenzie Do Paran\u00e1 Curitiba Paran\u00e1 Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Let\u00edcia Graziela Costa","family":"Santos","sequence":"additional","affiliation":[{"name":"Instituto Carlos Chagas FIOCRUZ Curitiba Paran\u00e1 Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Esdras Matheus Gomes da","family":"Silva","sequence":"additional","affiliation":[{"name":"Instituto Carlos Chagas FIOCRUZ Curitiba Paran\u00e1 Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vin\u00edcius Da Silva Coutinho","family":"Parreira","sequence":"additional","affiliation":[{"name":"Instituto Carlos Chagas FIOCRUZ Curitiba Paran\u00e1 Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luis Gustavo","family":"Morello","sequence":"additional","affiliation":[{"name":"Instituto Carlos Chagas FIOCRUZ Curitiba Paran\u00e1 Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fabricio Klerynton","family":"Marchini","sequence":"additional","affiliation":[{"name":"Instituto Carlos Chagas FIOCRUZ Curitiba Paran\u00e1 Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria Regina","family":"Tizzot","sequence":"additional","affiliation":[{"name":"Faculdade Evang\u00e9lica Mackenzie Do Paran\u00e1 Curitiba Paran\u00e1 Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mauricio Marcondes","family":"Ribas","sequence":"additional","affiliation":[{"name":"Hospital Universit\u00e1rio Evang\u00e9lico Mackenzie Curitiba Paran\u00e1 Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gilberto","family":"Pascolat","sequence":"additional","affiliation":[{"name":"Hospital Universit\u00e1rio Evang\u00e9lico Mackenzie Curitiba Paran\u00e1 Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carmen Australia Paredes Marcondes","family":"Ribas","sequence":"additional","affiliation":[{"name":"Faculdade Evang\u00e9lica Mackenzie Do Paran\u00e1 Curitiba Paran\u00e1 Brazil"},{"name":"Hospital Universit\u00e1rio Evang\u00e9lico Mackenzie Curitiba Paran\u00e1 Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"F\u00e1bio Fernandes da Rocha","family":"Vicente","sequence":"additional","affiliation":[{"name":"Federal University of Technology \u2010 Paran\u00e1 (UTFPR) Corn\u00e9lio Proc\u00f3pio Paran\u00e1 Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexandre Rossi","family":"Paschoal","sequence":"additional","affiliation":[{"name":"Federal University of Technology \u2010 Paran\u00e1 (UTFPR) Corn\u00e9lio Proc\u00f3pio Paran\u00e1 Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rubens","family":"Cat","sequence":"additional","affiliation":[{"name":"Departamento de Pediatria Universidade Federal do Paran\u00e1 Curitiba Paran\u00e1 Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Benilton de S\u00e1","family":"Carvalho","sequence":"additional","affiliation":[{"name":"Departamento de Estat\u00edstica Universidade Estadual de Campinas Campinas S\u00e3o Paulo Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jaqueline","family":"Carvalho de Oliveira","sequence":"additional","affiliation":[{"name":"Departamento de Gen\u00e9tica Universidade Federal do Paran\u00e1 Curitiba Paran\u00e1 Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marcus F.","family":"Oliveira","sequence":"additional","affiliation":[{"name":"Universidade Federal do Rio de Janeiro  Rio de Janeiro Brazil"},{"name":"Instituto Nacional de Ci\u00eancia e Tecnologia em Entomologia Molecular Rio de Janeiro Rio de Janeiro Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luiz Lehmann","family":"Coutinho","sequence":"additional","affiliation":[{"name":"Escola Superior de Agricultura Luiz de Queiroz (ESALQ) Universidade de S\u00e3o Paulo Piracicaba S\u00e3o Paulo Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ac\u00e1cia Maria Louren\u00e7o Francisco","family":"Nasr","sequence":"additional","affiliation":[{"name":"Secretaria da Sa\u00fade do Estado do Paran\u00e1 (SESA) Curitiba Paran\u00e1 Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Irina Nastassja","family":"Riediger","sequence":"additional","affiliation":[{"name":"Laborat\u00f3rio Central do Estado do Paran\u00e1 (LACEN) S\u00e3o Jos\u00e9 dos Pinhais Paran\u00e1 Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeanine Marie","family":"Nardin","sequence":"additional","affiliation":[{"name":"Escola de Medicina e Ci\u00eancias da Vida (EMCV) Pontif\u00edcia Universidade Cat\u00f3lica do Paran\u00e1 \u2013 PUCPR Curitiba Paran\u00e1 Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liya Regina","family":"Mikami","sequence":"additional","affiliation":[{"name":"Faculdade Evang\u00e9lica Mackenzie Do Paran\u00e1 Curitiba Paran\u00e1 Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ana Carolina Ramos","family":"Guimar\u00e3es","sequence":"additional","affiliation":[{"name":"Laborat\u00f3rio de Gen\u00f4mica Aplicada e Bioinova\u00e7\u00f5es (IOC), Instituto Oswaldo Cruz FIOCRUZ Rio de Janeiro Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4489-9148","authenticated-orcid":false,"given":"Patricia","family":"Savio de Araujo\u2010Souza","sequence":"additional","affiliation":[{"name":"Universidade Federal do Paran\u00e1 Curitiba Paran\u00e1 Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arnaldo","family":"Prata\u2010Barbosa","sequence":"additional","affiliation":[{"name":"Instituto D\u2032or de Pesquisa e Ensino  Rio de Janeiro Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zilton Farias Meira de","family":"Vasconcelos","sequence":"additional","affiliation":[{"name":"Laborat\u00f3rio de Alta Complexidade (LACIFF), Unidade de Pesquisa Cl\u00ednica, Instituto Fernandes Figueira FIOCRUZ  Rio de Janeiro Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Helisson","family":"Faoro","sequence":"additional","affiliation":[{"name":"Instituto Carlos Chagas FIOCRUZ Curitiba Paran\u00e1 Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hellen","family":"Geremias dos Santos","sequence":"additional","affiliation":[{"name":"Instituto Carlos Chagas FIOCRUZ Curitiba Paran\u00e1 Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5672-7848","authenticated-orcid":false,"given":"Fabio","family":"Passetti","sequence":"additional","affiliation":[{"name":"Instituto Carlos Chagas FIOCRUZ Curitiba Paran\u00e1 Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,8,16]]},"reference":[{"key":"e_1_2_9_2_1","unstructured":"Worldometers.info. Worldometer. (2025)."},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(20)30183-5"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1159\/000513400"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1097\/INF.0000000000002660"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(20)31129-6"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.3390\/children10060980"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa2021680"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.3389\/fgene.2022.928466"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.gene.2022.146790"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2022.09.005"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1186\/s10020-022-00583-5"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.3389\/fcimb.2023.1182257"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2020.07.033"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2021.06.024"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamanetworkopen.2022.14985"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.1093\/bioinformatics\/btu170"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.1093\/bioinformatics\/btq559"},{"key":"e_1_2_9_19_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13742-015-0047-8"},{"key":"e_1_2_9_20_1","doi-asserted-by":"publisher","DOI":"10.1145\/3107411.3108204"},{"key":"e_1_2_9_21_1","doi-asserted-by":"publisher","DOI":"10.1002\/humu.23220"},{"key":"e_1_2_9_22_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.adl3564"},{"key":"e_1_2_9_23_1","doi-asserted-by":"publisher","DOI":"10.1186\/gb-2005-6-5-r44"},{"key":"e_1_2_9_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajhg.2022.10.013"},{"key":"e_1_2_9_25_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrg3931"},{"key":"e_1_2_9_26_1","doi-asserted-by":"publisher","DOI":"10.1101\/gr.097857.109"},{"key":"e_1_2_9_27_1","doi-asserted-by":"publisher","DOI":"10.1038\/gim.2015.30"},{"key":"e_1_2_9_28_1","unstructured":"Franklin by QIAGEN https:\/\/franklin.genoox.com."},{"key":"e_1_2_9_29_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.xinn.2021.100141"},{"key":"e_1_2_9_30_1","doi-asserted-by":"publisher","DOI":"10.1093\/bioinformatics\/btu684"},{"key":"e_1_2_9_31_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-1-0716-0301-7_11"},{"key":"e_1_2_9_32_1","doi-asserted-by":"publisher","DOI":"10.1039\/C5MB00663E"},{"key":"e_1_2_9_33_1","first-page":"2825","article-title":"Scikit\u2010Learn: Machine Learning in Python","volume":"12","author":"Pedregosa F.","year":"2011","journal-title":"Journal of Machine Learning Research"},{"key":"e_1_2_9_34_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41592-019-0686-2"},{"key":"e_1_2_9_35_1","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gkae1010"},{"key":"e_1_2_9_36_1","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gkr703"},{"key":"e_1_2_9_37_1","doi-asserted-by":"publisher","DOI":"10.1002\/pro.3943"},{"key":"e_1_2_9_38_1","doi-asserted-by":"publisher","DOI":"10.1002\/pro.5560060807"},{"key":"e_1_2_9_39_1","doi-asserted-by":"publisher","DOI":"10.1134\/S1022795425700012"},{"key":"e_1_2_9_40_1","doi-asserted-by":"publisher","DOI":"10.1186\/s40246-022-00407-x"},{"key":"e_1_2_9_41_1","first-page":"583","article-title":"Long\u2010Term Cardiovascular Outcomes of COVID\u201019","volume":"28","author":"Xie Y.","year":"2022","journal-title":"Nature Medicine (New York, NY, United States)"},{"key":"e_1_2_9_42_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.heliyon.2023.e18575"},{"key":"e_1_2_9_43_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.2300566120"},{"key":"e_1_2_9_44_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cmet.2017.08.012"},{"key":"e_1_2_9_45_1","doi-asserted-by":"publisher","DOI":"10.3390\/cells9030715"},{"key":"e_1_2_9_46_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41556-017-0002-2"},{"key":"e_1_2_9_47_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.molcel.2022.06.002"},{"key":"e_1_2_9_48_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-020-15636-8"},{"key":"e_1_2_9_49_1","doi-asserted-by":"publisher","DOI":"10.1002\/eji.202149481"},{"key":"e_1_2_9_50_1","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2021.720283"},{"key":"e_1_2_9_51_1","doi-asserted-by":"publisher","DOI":"10.3390\/cancers11081097"},{"key":"e_1_2_9_52_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-021-86747-5"},{"key":"e_1_2_9_53_1","doi-asserted-by":"publisher","DOI":"10.1128\/jvi.00600-21"},{"key":"e_1_2_9_54_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-022-29951-9"},{"key":"e_1_2_9_55_1","doi-asserted-by":"publisher","DOI":"10.3389\/fcvm.2022.1033660"},{"key":"e_1_2_9_56_1","doi-asserted-by":"publisher","DOI":"10.1194\/jlr.TR119000267"},{"key":"e_1_2_9_57_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jbc.2023.104763"},{"key":"e_1_2_9_58_1","doi-asserted-by":"publisher","DOI":"10.1093\/cvr\/cvu150"},{"key":"e_1_2_9_59_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M801408200"},{"key":"e_1_2_9_60_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cmet.2017.04.005"},{"key":"e_1_2_9_61_1","doi-asserted-by":"publisher","DOI":"10.3389\/fcimb.2024.1444216"},{"key":"e_1_2_9_62_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pcbi.1002375"},{"key":"e_1_2_9_63_1","article-title":"Whole\u2010Exome Sequencing of Pediatric Patients With Multisystem Inflammatory Syndrome and Severe COVID\u201019","author":"Urbanski A. H.","year":"2025","journal-title":"NCBI BioProject"}],"container-title":["Journal of Medical Virology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/jmv.70556","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/jmv.70556","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/jmv.70556","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,7,12]],"date-time":"2026-07-12T05:03:37Z","timestamp":1783832617000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/jmv.70556"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,8]]},"references-count":62,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2025,8]]}},"alternative-id":["10.1002\/jmv.70556"],"URL":"https:\/\/doi.org\/10.1002\/jmv.70556","archive":["Portico"],"relation":{},"ISSN":["0146-6615","1096-9071"],"issn-type":[{"value":"0146-6615","type":"print"},{"value":"1096-9071","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,8]]},"assertion":[{"value":"2025-02-28","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-08-04","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-08-16","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e70556"}}