{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,12]],"date-time":"2026-07-12T05:07:42Z","timestamp":1783832862124,"version":"3.55.0"},"reference-count":32,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2025,8,19]],"date-time":"2025-08-19T00:00:00Z","timestamp":1755561600000},"content-version":"vor","delay-in-days":18,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2025,8,1]],"date-time":"2025-08-01T00:00:00Z","timestamp":1754006400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal of Medical Virology"],"published-print":{"date-parts":[[2025,8]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    Chronic high Epstein\u2010Barr virus (EBV) load (CHL) carriage has been closely associated with EBV infection after pediatric liver transplantation. Elevated tacrolimus (Tac) blood concentrations increased the risk of EBV\u2010associated diseases. Tacrolimus intra\u2010patient variability (Tac\u2010IPV) help predict poor outcomes. This study examines whether Tac\u2010IPV correlate with CHL carriage in living\u2010donor\u2010dominant pediatric liver transplantation. We analyzed the clinical data of 153 pediatric liver transplant recipients receiving Tac treatment with a 2\u2010year follow\u2010up period. Tac\u2010IPV quantification as coefficient of variation (CV). CHL was defined as EBV DNA &gt;\u200916,000 copies\/mL in whole blood or &gt;\u2009200 copies\/10\n                    <jats:sup>5<\/jats:sup>\n                    peripheral blood mononuclear cells in \u2265\u200950% of samples over 6 months. The results showed that 81 cases (52.94%) of recipients developed CHL after liver transplantation. CV\u2010IPV (\n                    <jats:italic>OR<\/jats:italic>\n                    \u2009=\u20091.034, 95%\n                    <jats:italic>CI<\/jats:italic>\n                    : 1.006\u20131.063,\n                    <jats:italic>p<\/jats:italic>\n                    \u2009=\u20090.019) was an independent risk factor for CHL carriage. Additional risk factors included younger age, absence of mycophenolate mofetil use, and earlier timing of first EBV viremia. In conclusion, CHL carriage development in pediatric liver transplant recipients is positively correlated with Tac\u2010IPV.\n                  <\/jats:p>","DOI":"10.1002\/jmv.70562","type":"journal-article","created":{"date-parts":[[2025,8,19]],"date-time":"2025-08-19T09:16:28Z","timestamp":1755594988000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Chronic High Epstein\u2010Barr Viral Load Carriage Is Positively Correlated With Tacrolimus Intra\u2010Patient Variability After Pediatric Liver Transplantation"],"prefix":"10.1002","volume":"97","author":[{"given":"Anrui","family":"Wang","sequence":"first","affiliation":[{"name":"Department of Hepatobiliary Surgery Children's Hospital of Chongqing Medical University, Chongqing Key Laboratory of Pediatrics, National Clinical Research Center for Child Health and Disorders Ministry of Education Key Laboratory of Child Development and Disorders Chongqing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoke","family":"Dai","sequence":"additional","affiliation":[{"name":"Department of Hepatobiliary Surgery Children's Hospital of Chongqing Medical University, Chongqing Key Laboratory of Pediatrics, National Clinical Research Center for Child Health and Disorders Ministry of Education Key Laboratory of Child Development and Disorders Chongqing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chenyu","family":"Yang","sequence":"additional","affiliation":[{"name":"Department of Hepatobiliary Surgery Children's Hospital of Chongqing Medical University, Chongqing Key Laboratory of Pediatrics, National Clinical Research Center for Child Health and Disorders Ministry of Education Key Laboratory of Child Development and Disorders Chongqing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bingqian","family":"Tan","sequence":"additional","affiliation":[{"name":"Department of Hepatobiliary Surgery Children's Hospital of Chongqing Medical University, Chongqing Key Laboratory of Pediatrics, National Clinical Research Center for Child Health and Disorders Ministry of Education Key Laboratory of Child Development and Disorders Chongqing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mingman","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Hepatobiliary Surgery Children's Hospital of Chongqing Medical University, Chongqing Key Laboratory of Pediatrics, National Clinical Research Center for Child Health and Disorders Ministry of Education Key Laboratory of Child Development and Disorders Chongqing 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