{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,30]],"date-time":"2026-10-30T22:10:09Z","timestamp":1793398209296,"version":"4.5.0"},"reference-count":49,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2025,8,30]],"date-time":"2025-08-30T00:00:00Z","timestamp":1756512000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal of Medical Virology"],"published-print":{"date-parts":[[2025,9]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    B cell is a crucial component of adaptive immunity that plays a paramount role in the progression and prognosis of chronic hepatitis B virus (HBV) infection. However, detailed and systematic overviews of B cells are lacking, hindering their clinical applications in fighting against HBV. This study aims to provide a landscape of B cell responses in the context of chronic HBV infection. The phenotype, function, and transcriptome features of the peripheral and intrahepatic B cells in cross\u2010sectional and longitudinal cohorts of patients with chronic HBV infection were characterized using single\u2010cell RNA sequencing analysis coupled with flow cytometry. B cells displayed varying degrees of altered function at different natural stages of chronic HBV infection, as evidenced by their inhibitory phenotype, reduced B cell receptor (BCR) signaling, resulting in decreased production of antiviral cytokines, attenuated differentiation into memory B cells, weakened interactions with T cells. Additionally, in patients with chronic HBV infection, intrahepatic B cells exhibited augmented BCR signaling, cytokine secretion, differentiation, and intensified interactions with other immune cells, compared to their peripheral counterparts. It is noteworthy that CCR7\n                    <jats:sup>+<\/jats:sup>\n                    B cells, characterized by high expression of activation markers and IL\u20106, exhibited enhanced survival capacity and were elevated in treatment\u2010responsive patients. Our study provides a detailed insight into the B cell response in chronic HBV infection and highlights the potential clinical application of CCR7\u2010expressing B cell\u2010oriented anti\u2010HBV therapy.\n                  <\/jats:p>","DOI":"10.1002\/jmv.70572","type":"journal-article","created":{"date-parts":[[2025,8,30]],"date-time":"2025-08-30T07:20:37Z","timestamp":1756538437000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Single\u2010Cell Profiling of Peripheral and Intrahepatic B Cells Reveals Altered Responses and a CCR7\u207a Subset Linked to Antiviral Potential in Chronic HBV Infection"],"prefix":"10.1002","volume":"97","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1075-6322","authenticated-orcid":false,"given":"Shihong","family":"Zhong","sequence":"first","affiliation":[{"name":"Department of Infectious Diseases, Nanfang Hospital Southern Medical University, State Key Laboratory of Organ 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