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HLH triggered by the evolving respiratory syncytial virus (RSV) is rare. HLH is characterized by excessive immune activation and is life\u2010threatening with high mortality. We show that tocilizumab led to a rapid clinical improvement in a multirefractory RSV\u2010induced HLH patient. Tocilizumab appears to be a promising therapeutic option and is well\u2010tolerated.<\/jats:p>","DOI":"10.1002\/jmv.70577","type":"journal-article","created":{"date-parts":[[2025,8,23]],"date-time":"2025-08-23T11:24:16Z","timestamp":1755948256000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Successful Treatment With Tocilizumab for Refractory RS\u2010Virus\u2010Induced Hemophagocytic Lymphohistiocytosis in Multiple Myeloma"],"prefix":"10.1002","volume":"97","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6381-9908","authenticated-orcid":false,"given":"Henk\u2010Jan","family":"Boiten","sequence":"first","affiliation":[{"name":"Department of Hematology Franciscus Gasthuis and Vlietland Schiedam the Netherlands"},{"name":"Department of Internal Medicine\u2014Hematology Franciscus Gasthuis and Vlietland Schiedam the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert F.","family":"Hoedemaeker","sequence":"additional","affiliation":[{"name":"Department of Pathology Pathan Rotterdam the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ward (EJ)","family":"Libourel","sequence":"additional","affiliation":[{"name":"Department of Hematology Franciscus Gasthuis and Vlietland Schiedam the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,8,23]]},"reference":[{"key":"e_1_2_1_9_2_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood.2018894618"},{"key":"e_1_2_1_9_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.blre.2016.05.001"},{"key":"e_1_2_1_9_4_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood.2021012764"},{"key":"e_1_2_1_9_5_1","doi-asserted-by":"publisher","DOI":"10.3390\/idr16020012"},{"key":"e_1_2_1_9_6_1","doi-asserted-by":"publisher","DOI":"10.1056\/nejmra2314005"},{"key":"e_1_2_1_9_7_1","doi-asserted-by":"publisher","DOI":"10.3390\/jcm12041696"},{"key":"e_1_2_1_9_8_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2022.955523"},{"key":"e_1_2_1_9_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.chest.2024.06.1282"},{"key":"e_1_2_1_9_10_1","doi-asserted-by":"publisher","DOI":"10.1155\/2020\/8833196"},{"key":"e_1_2_1_9_11_1","doi-asserted-by":"publisher","DOI":"10.1002\/hon.2819"},{"key":"e_1_2_1_9_12_1","doi-asserted-by":"publisher","DOI":"10.1007\/s15010-025-02559-z"},{"key":"e_1_2_1_9_13_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2017.01102"},{"key":"e_1_2_1_9_14_1","doi-asserted-by":"publisher","DOI":"10.1111\/bjh.14147"}],"container-title":["Journal of Medical Virology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/jmv.70577","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/jmv.70577","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/jmv.70577","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,7,12]],"date-time":"2026-07-12T05:04:08Z","timestamp":1783832648000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/jmv.70577"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,8]]},"references-count":13,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2025,8]]}},"alternative-id":["10.1002\/jmv.70577"],"URL":"https:\/\/doi.org\/10.1002\/jmv.70577","archive":["Portico"],"relation":{},"ISSN":["0146-6615","1096-9071"],"issn-type":[{"value":"0146-6615","type":"print"},{"value":"1096-9071","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,8]]},"assertion":[{"value":"2025-06-19","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-08-14","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-08-23","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e70577"}}