{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,4]],"date-time":"2026-06-04T03:57:08Z","timestamp":1780545428647,"version":"3.54.1"},"reference-count":49,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2025,8,29]],"date-time":"2025-08-29T00:00:00Z","timestamp":1756425600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal of Medical Virology"],"published-print":{"date-parts":[[2025,9]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    This study aimed to determine the occurrence and risk factors for persistent symptoms after mild to moderate severe acute respiratory syndrome coronavirus 2 (SARS\u2010CoV\u20102) infection in patients who presented in primary care during the 2021 pandemic. A retrospective cross\u2010sectional survey was conducted in six public family health care units in Joao Pessoa, Brazil. A questionnaire with a set of 18 validated clinical outcomes was used to assess prolonged symptoms beyond 3 months of duration in 226 adults who had confirmed SARS\u2010CoV\u20102 infection. Binary logistic regression models were used to estimate adjusted odds ratios (aOR) and risk factors for Long COVID. A total of 16 outcomes were significantly associated with Long COVID. The largest aOR were estimated for short\u2010term memory loss, anxiety, and loss of attention. The risk factors for Long COVID included \u2265\u20095 symptoms (15.82, 7.33\u201334.15,\n                    <jats:italic>p<\/jats:italic>\n                    \u2009&lt;\u20090.0001), female sex (aOR: 1.91, 95% CI: 1.03\u20133.53,\n                    <jats:italic>p<\/jats:italic>\n                    \u2009=\u20090.032), age 40\u201349 years (3.45, 1.14\u201310.51,\n                    <jats:italic>p<\/jats:italic>\n                    \u2009=\u20090.029), and age 70+ years (4.0, 1.01\u201315.51,\n                    <jats:italic>p<\/jats:italic>\n                    \u2009=\u20090.045). Findings highlight a high frequency of persistent symptoms in adults who initially had non\u2010severe SARS\u2010CoV\u20102 infection, who are predominantly of working age, and who did not present multiple comorbidities. This study supports the need for assessing clinical outcomes and risk factors on Long COVID in primary care using routinely recorded clinical outcomes.\n                  <\/jats:p>","DOI":"10.1002\/jmv.70579","type":"journal-article","created":{"date-parts":[[2025,8,29]],"date-time":"2025-08-29T13:25:15Z","timestamp":1756473915000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Symptoms and Risk Factors for Long COVID: A Cross\u2010Sectional Study in Primary Care"],"prefix":"10.1002","volume":"97","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7371-3752","authenticated-orcid":false,"given":"Assel Muratovna Shigayeva","family":"Ferreira","sequence":"first","affiliation":[{"name":"Center of Exact Sciences and Nature Federal University of Para\u00edba Joao Pessoa Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fl\u00e1via Em\u00edlia Leite de Lima","family":"Ferreira","sequence":"additional","affiliation":[{"name":"Center of Health Sciences Federal University of Paraiba Joao Pessoa Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Caio C\u00e9sar Ferreira","family":"Alverga","sequence":"additional","affiliation":[{"name":"Center of Health Sciences Federal University of Paraiba Joao Pessoa Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jo\u00e3o Agnaldo do","family":"Nascimento","sequence":"additional","affiliation":[{"name":"Center of Exact Sciences and Nature Federal University of Para\u00edba Joao Pessoa Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andr\u00e9 Lu\u00eds Bonif\u00e1cio","family":"de Carvalho","sequence":"additional","affiliation":[{"name":"Center of Medical Sciences Federal University of Paraiba Joao Pessoa Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gabriel Rodrigues Martins","family":"de Freitas","sequence":"additional","affiliation":[{"name":"Center of Health Sciences Federal University of Paraiba Joao Pessoa Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jo\u00e3o Aur\u00edlio Cardoso","family":"de Moraes","sequence":"additional","affiliation":[{"name":"Center of Medical Sciences Federal University of Paraiba Joao Pessoa Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Izabele da Silva","family":"Rocha","sequence":"additional","affiliation":[{"name":"Center of Health Sciences Federal University of Paraiba Joao Pessoa Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lucas Tomaz da","family":"Silva","sequence":"additional","affiliation":[{"name":"Center of Medical Sciences Federal University of Paraiba Joao Pessoa Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Beatriz Carolinny Pereira da Silva","family":"Alves","sequence":"additional","affiliation":[{"name":"Center of Medical Sciences Federal University of Paraiba Joao Pessoa Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cleidilaine Ramos","family":"de Oliveira","sequence":"additional","affiliation":[{"name":"Center of Medical Sciences Federal University of Paraiba Joao Pessoa Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jos\u00e9 Ricardo Araujo","family":"Cardoso","sequence":"additional","affiliation":[{"name":"Center of Medical Sciences Federal University of Paraiba Joao Pessoa Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ruth Maria Mendon\u00e7a","family":"Anacleto","sequence":"additional","affiliation":[{"name":"Center of Medical Sciences Federal University of Paraiba Joao Pessoa Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Leandro","family":"Pernambuco","sequence":"additional","affiliation":[{"name":"Center of Medical Sciences Federal University of Pernambuco Recife Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,8,29]]},"reference":[{"key":"e_1_2_10_2_1","unstructured":"World Health Organization. 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London: ONS;2021 [cited 2024 November 16] https:\/\/www.ons.gov.uk\/peoplepopulationandcommunity\/healthandsocialcare\/healthandlifeexpectancies\/adhocs\/12788updatedestimatesoftheprevalenceoflongcovidsymptoms."},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1093\/infdis\/jiac136"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.eclinm.2021.101019"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.eclinm.2022.101762"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41591-021-01292-y"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1183\/23120541.00542-2020"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmjgh-2021-005427"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/S2213-2600(22)00169-2"},{"key":"e_1_2_10_13_1","unstructured":"C. C. 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