{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,29]],"date-time":"2026-10-29T07:14:14Z","timestamp":1793258054352,"version":"4.5.0"},"reference-count":55,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2025,9,5]],"date-time":"2025-09-05T00:00:00Z","timestamp":1757030400000},"content-version":"vor","delay-in-days":4,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000025","name":"National Institute of Mental Health","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000025","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal of Medical Virology"],"published-print":{"date-parts":[[2025,9]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>Mother\u2010to\u2010child transmission (MTCT) is the primary route of human T\u2010lymphotropic virus type 1 (HTLV\u20101) infection. Although formula feeding reduces breastfeeding\u2010associated transmission, MTCT still occurs, implicating pregnancy or delivery as key transmission windows. In this study, placental tissues from nine HTLV\u20101\u2013positive mothers were analyzed using DNA\/RNAscope, revealing low HTLV\u20101 DNA and RNA levels and a low RNA\/DNA ratio, consistent with latent infection in the placenta and potentially explaining the low MTCT rate. Elevated interferon (IFN)\u2010\u03b2 levels were observed in infected placentas compared to seronegative controls, while IFN\u03b1, IFN\u03b3, and IFITM expression remained unchanged. Concurrently, sustained IFN\u03b2 expression in infected placentas suggests its dual roles in HTLV\u20101 pathogenesis: suppressing viral replication while potentially disrupting placental homeostasis through chronic inflammation. In vitro modeling using BeWo cells or primary trophoblasts cocultured with HTLV\u20101\u2010infected MT\u20102 cells demonstrated syncytin\u20101\u2010mediated viral entry, confirmed by HTLV\u20101 p19 detection in both trophoblasts. Of note, HTLV\u20101 transmission was abolished by a syncytin\u20101\u2010specific fusion inhibitor HRB1, underscoring syncytin\u20101's essential role in cell\u2010to\u2010cell transmission of HTLV\u20101. Thus, this study identifies syncytin\u20101 as a therapeutic target to block vertical transmission and highlights the need to balance antiviral responses with placental integrity in HTLV\u20101 management.<\/jats:p>","DOI":"10.1002\/jmv.70585","type":"journal-article","created":{"date-parts":[[2025,9,5]],"date-time":"2025-09-05T09:48:11Z","timestamp":1757065691000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Persistent Human T\u2010Lymphotropic Virus Type 1 (HTLV\u20101) Infection in the Placenta of Pregnant Women"],"prefix":"10.1002","volume":"97","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3728-9621","authenticated-orcid":false,"given":"Gabriela","family":"Prates","sequence":"first","affiliation":[{"name":"Laboratory of Dermatology and Immunodeficiencies, Department of Dermatology University of S\u00e3o Paulo Medical School S\u00e3o Paulo Brazil"},{"name":"UNC HIV Cure Center University of North Carolina Chapel Hill North Carolina USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoyi","family":"Li","sequence":"additional","affiliation":[{"name":"UNC HIV Cure Center University of North Carolina Chapel Hill North Carolina USA"},{"name":"Institute of Global Health &amp; Infectious Diseases University of North Carolina Chapel Hill North Carolina USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Victor","family":"Folgosi","sequence":"additional","affiliation":[{"name":"Laboratory of Dermatology and Immunodeficiencies, Department of Dermatology University of S\u00e3o Paulo Medical School S\u00e3o Paulo Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"George","family":"Souza","sequence":"additional","affiliation":[{"name":"Laboratory of Dermatology and Immunodeficiencies, Department of Dermatology University of S\u00e3o Paulo Medical School S\u00e3o Paulo Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sandy","family":"Teixeira","sequence":"additional","affiliation":[{"name":"Laboratory of Dermatology and Immunodeficiencies, Department of Dermatology University of S\u00e3o Paulo Medical School S\u00e3o Paulo Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carlos","family":"Apoliano","sequence":"additional","affiliation":[{"name":"Laboratory of Dermatology and Immunodeficiencies, Department of Dermatology University of S\u00e3o Paulo Medical School S\u00e3o Paulo Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fernanda","family":"Grassi","sequence":"additional","affiliation":[{"name":"Gon\u00e7alo Moniz Institute Oswaldo Cruz Foundation (FIOCRUZ) Salvador Bahia Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jacielma","family":"Freire","sequence":"additional","affiliation":[{"name":"Clim\u00e9rio de Oliveira Maternity Hospital Bahia Federal University of Bahia (UFABA)  Bahia Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jerusa","family":"Smid","sequence":"additional","affiliation":[{"name":"Institute of Infectious Diseases \u201cEmilio Ribas\u201d (IIER) de S\u00e3o Paulo S\u00e3o Paulo SP Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michel E.","family":"Haziot","sequence":"additional","affiliation":[{"name":"Institute of Infectious Diseases \u201cEmilio Ribas\u201d (IIER) de S\u00e3o Paulo S\u00e3o Paulo SP Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rosa Maria N.","family":"Marcusso","sequence":"additional","affiliation":[{"name":"Institute of Infectious Diseases \u201cEmilio Ribas\u201d (IIER) de S\u00e3o Paulo S\u00e3o Paulo SP Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Augusto C. 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