{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,27]],"date-time":"2026-08-27T20:28:34Z","timestamp":1787862514846,"version":"build-2784847793"},"reference-count":31,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2025,9,5]],"date-time":"2025-09-05T00:00:00Z","timestamp":1757030400000},"content-version":"vor","delay-in-days":4,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal of Medical Virology"],"published-print":{"date-parts":[[2025,9]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>The genetic variant CCR5\u039432 is mostly represented in European populations and has been studied for its protective effect against human immunodeficiency virus (HIV) infection. The Berlin patient and others have received a haematopoietic stem cell (HSC) transplant from CCR5\u039432\/\u039432\u2010HLA compatible donors and are considered cured for HIV. Several studies emphasize the need to seek donors with this condition in the HSC registries. The frequency of the CCR5\u039432 allele is unknown in Argentina. The aim of this study was to determine the frequency of the CCR5\u039432 allele and genotype in donors registered in the National Registry of HSC\u2010INCUCAI\u2010Argentina, and to evaluate possible implications in transplantation of HIV patients. A total of 238\u2009874 blood samples were analyzed molecularly for CCR5\u039432\/HLA. In the population, we report a frequency of 5.46% for CCR5\u039432 and 10.38% and 0.27% in the CCR5\u039432\/WT and CCR5\u039432\/\u039432, respectively. The genotypes registered some differences at the national level and depending on the donor's ancestry. In addition, a homogeneous distribution of HLA alleles was identified between carriers and non\u2010carriers of CCR5\u039432. We report the allelic and genotypic frequencies of CCR5\u039432 in Argentina, and its distribution, considering search strategies for CCR5\u039432\/\u039432 donors that provide a transplant alternative to patients infected with HIV.<\/jats:p>","DOI":"10.1002\/jmv.70591","type":"journal-article","created":{"date-parts":[[2025,9,5]],"date-time":"2025-09-05T07:29:11Z","timestamp":1757057351000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Frequency of the CCR5\u039432 Variant in Haematopoietic Progenitor Cell Donors From Argentina: Implications for Transplantation in HIV\u20101 Infected Patients"],"prefix":"10.1002","volume":"97","author":[{"given":"Pablo","family":"Galarza","sequence":"first","affiliation":[{"name":"Laboratorio Nacional de Inmunogenetica (LNI), Instituto Nacional Central \u00danico Coordinador de Ablaci\u00f3n e Implante (INCUCAI) Ciudad Aut\u00f3noma de Buenos Aires Argentina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laura","family":"Aguerre","sequence":"additional","affiliation":[{"name":"Registro Nacional de Donantes de C\u00e9lulas Progenitoras Hematopoy\u00e9ticas (RNDCPH), INCUCAI  Argentina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Demian","family":"Procopio","sequence":"additional","affiliation":[{"name":"Unidad de Conocimiento Traslacional (UCT), INCUCAI Ciudad Aut\u00f3noma de Buenos Aires Argentina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniela Hansen","family":"Krogh","sequence":"additional","affiliation":[{"name":"Direcci\u00f3n de Tecnolog\u00edas y Sistemas de la Informaci\u00f3n, INCUCAI Ciudad Aut\u00f3noma de Buenos Aires Argentina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gabriela","family":"Hidalgo","sequence":"additional","affiliation":[{"name":"Directorio, INCUCAI Ciudad Aut\u00f3noma de Buenos Aires Argentina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carlos A.","family":"Soratti","sequence":"additional","affiliation":[{"name":"Directorio, INCUCAI Ciudad Aut\u00f3noma de Buenos Aires Argentina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Richard","family":"Malan","sequence":"additional","affiliation":[{"name":"Directorio, INCUCAI Ciudad Aut\u00f3noma de Buenos Aires Argentina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6915-193X","authenticated-orcid":false,"given":"Cecilia Mar\u00eda","family":"Delfino","sequence":"additional","affiliation":[{"name":"Consejo Nacional de Investigaciones Cient\u00edficas y T\u00e9cnicas (CONICET) \u2013 UCT INCUCAI Ciudad Aut\u00f3noma de Buenos Aires Argentina"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,9,5]]},"reference":[{"key":"e_1_2_8_2_1","unstructured":"C. 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