{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,15]],"date-time":"2025-11-15T10:13:20Z","timestamp":1763201600948,"version":"3.45.0"},"reference-count":21,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2025,9,5]],"date-time":"2025-09-05T00:00:00Z","timestamp":1757030400000},"content-version":"vor","delay-in-days":4,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal of Medical Virology"],"published-print":{"date-parts":[[2025,9]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    Human herpesvirus 8 (HHV\u20108) positivity rates vary across regions. The rates are higher in immunosuppressed patients. There is a potential association between HHV\u20108 and type 2 diabetes. The aim of this study is to determine the prevalence of HHV\u20108 infection in type 2 diabetes patients and healthy blood donors, and to investigate whether the presence of the infection could be a risk factor for type 2 diabetes. In this cross\u2010sectional study, 90 type 2 diabetes patients and 180 healthy blood donors were included between July and October 2024 at Ankara Etlik City Hospital. HHV\u20108 IgG seroprevalence was assessed using enzyme\u2010linked immunosorbent assay, and HHV\u20108 DNA was detected via real\u2010time polymerase chain reaction. HHV\u20108 seropositivity was detected in 7.8% of type 2 diabetes patients and 6.1% of blood donors, with no statistically significant difference between the two groups (\n                    <jats:italic>p<\/jats:italic>\n                    \u2009=\u20090.605). The odds ratio of HHV\u20108 infection in the type 2 diabetes group compared to the blood donor group was 1.29 (95% CI: 0.48\u20133.46,\n                    <jats:italic>p<\/jats:italic>\n                    \u2009=\u20090.605), indicating no significant association between HHV\u20108 and diabetes. No HHV\u20108 DNA was detected in any participant. Seropositivity was most prevalent in the 51\u201365 age group among diabetic patients and in the 31\u201340 age group among blood donors. There was no significant correlation between HHV\u20108 seropositivity and diabetes duration, sex, or age. HHV\u20108 seroprevalence was similar in type 2 diabetes patients and blood donors, suggesting no significant association between HHV\u20108 infection and diabetes. However, due to regional differences, methodological variations, and limited sample size, further large\u2010scale, multicenter studies with long\u2010term follow\u2010up are necessary to clarify the potential role of HHV\u20108 in type 2 diabetes pathogenesis.\n                  <\/jats:p>","DOI":"10.1002\/jmv.70593","type":"journal-article","created":{"date-parts":[[2025,9,5]],"date-time":"2025-09-05T07:51:28Z","timestamp":1757058688000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Prevalence of Human Herpesvirus 8 Infection in Patients With Type 2 Diabetes and Blood Donors"],"prefix":"10.1002","volume":"97","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5227-7111","authenticated-orcid":false,"given":"Eyl\u00fcl Beren","family":"Tan\u0131k","sequence":"first","affiliation":[{"name":"National Virology Reference Laboratory, Ministry of Health General Directorate of Public Health Ankara T\u00fcrkiye"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9006-5267","authenticated-orcid":false,"given":"Ayfer","family":"Bak\u0131r","sequence":"additional","affiliation":[{"name":"Department of Microbiology University of Health Sciences Ankara Etlik City Hospital Ankara T\u00fcrkiye"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bet\u00fcl","family":"Y\u00fcz\u00fcg\u00fcld\u00fc","sequence":"additional","affiliation":[{"name":"National Virology Reference Laboratory, Ministry of Health General Directorate of Public Health Ankara T\u00fcrkiye"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0004-0257-5104","authenticated-orcid":false,"given":"Gizem","family":"Korkut","sequence":"additional","affiliation":[{"name":"Department of Microbiology University of Health Sciences Ankara Etlik City Hospital Ankara T\u00fcrkiye"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Muhammed Furkan","family":"K\u00fcrk\u00e7\u00fc","sequence":"additional","affiliation":[{"name":"Department of Microbiology University of Health Sciences Ankara Etlik City Hospital Ankara T\u00fcrkiye"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"\u0130lknur \u00d6zt\u00fcrk","family":"\u00dcnsal","sequence":"additional","affiliation":[{"name":"Department of Endocrinology University of Health Sciences Ankara Etlik City Hospital Ankara 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