{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,15]],"date-time":"2025-11-15T10:13:32Z","timestamp":1763201612854,"version":"3.45.0"},"reference-count":35,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2025,9,14]],"date-time":"2025-09-14T00:00:00Z","timestamp":1757808000000},"content-version":"vor","delay-in-days":13,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal of Medical Virology"],"published-print":{"date-parts":[[2025,9]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    The respiratory syncytial virus (RSV) is a predominant pathogen that causes lower respiratory tract infections and is widespread among infants and the elderly. Antibodies and antiviral drugs are effective treatment strategies for RSV, but their efficacy varies among different animal models. Here, we present a mouse model constructed using HEp\u20102 cell line\u2010derived xenograft (HEp2\u2010CDX) technology. The HEp2\u2010CDX mouse model sustained high viral loads following both intratumoral and intravenous inoculation with RSV. The average peak titers rapidly reached 1 \u00d7 10\n                    <jats:sup>7<\/jats:sup>\n                    copies\/g in lung tissues and 6 \u00d7 10\n                    <jats:sup>9<\/jats:sup>\n                    copies\/g in the tumor tissues over a period up to 5 days. Furthermore, the addition of a clinical monoclonal antibody (nirsevimab) and an antiviral drug (ziresovir) showed strong antiviral activity within this animal model. These findings suggest that HEp2\u2010CDX mice, which enable stable RSV infection and replication, serve as useful models for evaluating antiviral therapeutics.\n                  <\/jats:p>","DOI":"10.1002\/jmv.70601","type":"journal-article","created":{"date-parts":[[2025,9,15]],"date-time":"2025-09-15T05:54:26Z","timestamp":1757915666000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Development of a HEp2\u2010CDX Mouse Model With Sustained High RSV Viral Loads for Robust Antiviral Therapeutic Evaluation"],"prefix":"10.1002","volume":"97","author":[{"ORCID":"https:\/\/orcid.org\/0009-0005-4131-8773","authenticated-orcid":false,"given":"Jinwei","family":"Yuan","sequence":"first","affiliation":[{"name":"Guangzhou National Laboratory Guangzhou China"},{"name":"School of Pharmaceutical Sciences Shenzhen Campus of Sun Yat\u2010sen University Shenzhen 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