{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,29]],"date-time":"2026-08-29T07:12:26Z","timestamp":1787987546285,"version":"build-2784847793"},"reference-count":51,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2025,9,26]],"date-time":"2025-09-26T00:00:00Z","timestamp":1758844800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2025,9,26]],"date-time":"2025-09-26T00:00:00Z","timestamp":1758844800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal of Medical Virology"],"published-print":{"date-parts":[[2025,10]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>Previous studies showed the association between sexually transmitted infections (STIs) and cervical lesions remains ambiguous. This study was conducted among 8371 women from a screening cohort. Seven specific sexually transmitted pathogens (STPs), including one viral [high\u2010risk human papillomavirus (hrHPV), low\u2010risk HPV (lrHPV)], five bacterial [Ureaplasma parvum (UP), Mycoplasma hominis (MH), Ureaplasma urealyticum (UU), Chlamydia trachomatis (CT), and Mycoplasma genitalium (MG)], and one parasitic [Trichomonas vaginalis (TV)] pathogen, were tested by Next Generation Sequencing assay using well\u2010stored baseline samples. Odds ratios (ORs) for incident cervical lesions with different STPs were calculated by Logistic Regression analysis. Within 3\u2010year follow\u2010up, 133 and 72 participants were diagnosed with histopathological cervical intraepithelial neoplasia grade 1 (CIN1) and CIN2+, respectively. The adjusted ORs (aORs) of atypical squamous cells of undetermined significance or worse (ASC\u2010US+) for women with hrHPV, lrHPV, UP, MH, TV, CT, and MG infections were 2.62 (95% CI: 2.19\u20133.13), 1.94 (95% CI: 1.55\u20132.43), 1.48 (95% CI: 1.26\u20131.74), 1.47 (95% CI: 1.25\u20131.73), 1.65 (95% CI: 1.27\u20132.15), 1.26 (95% CI: 0.79\u20132.01) and 2.33 (95% CI: 1.41\u20133.85), respectively. The aORs of cytological high\u2010grade squamous intraepithelial lesions (HSIL) for women with hrHPV, TV, and MG infections were 13.01 (95% CI: 5.78\u201329.31), 3.48 (95% CI: 1.38\u20138.75), and 5.87 (95% CI: 1.58\u201321.77). The aORs of CIN1 for hrHPV, lrHPV, and MH were 6.88(95% CI: 4.79\u20139.90), 2.04(95% CI: 1.29\u20133.14), and 1.47(95% CI: 1.02\u20132.11). The aOR of CIN2+ for women with hrHPV infection was 17.56 (95% CI: 10.31\u201329.92), no significance was observed for CIN2+ with non\u2010hrHPV STIs. Specific STP infections were significantly associated with subsequent cervical cytological ASC\u2010US+ (hrHPV, lrHPV, UP, MH, TV, and MG) and HSIL (hrHPV, TV, and MG). Infection with lrHPV and MH could increase the CIN1 risk in future though no obvious CIN2+ risk elevation was observed.<\/jats:p>","DOI":"10.1002\/jmv.70616","type":"journal-article","created":{"date-parts":[[2025,9,26]],"date-time":"2025-09-26T09:10:31Z","timestamp":1758877831000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["The Impact of Specific Sexually Transmitted Pathogens on Cervix: A Prospective Study Based on Cervical Cancer Screening Cohort"],"prefix":"10.1002","volume":"97","author":[{"given":"Simiao","family":"Chen","sequence":"first","affiliation":[{"name":"National Cancer Center\/National Clinical Research Center for Cancer\/Cancer Hospital Chinese Academy of Medical Sciences and Peking Union Medical College Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tingyuan","family":"Li","sequence":"additional","affiliation":[{"name":"National Cancer Center\/National Clinical Research Center for Cancer\/Cancer Hospital Chinese Academy of Medical Sciences and Peking Union Medical College Beijing China"},{"name":"Sichuan Clinical Research Center for Cancer, Sichuan Cancer Hospital &amp; Institute, Sichuan Cancer Center University of Electronic Science and Technology of China Chengdu China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yakun","family":"Wang","sequence":"additional","affiliation":[{"name":"National Cancer Center\/National Clinical Research Center for Cancer\/Cancer Hospital Chinese Academy of Medical Sciences and Peking Union Medical College Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4048-8093","authenticated-orcid":false,"given":"Yu","family":"Dai","sequence":"additional","affiliation":[{"name":"National Cancer Center\/National Clinical Research Center for Cancer\/Cancer Hospital Chinese Academy of Medical Sciences and Peking Union Medical College Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qinjing","family":"Pan","sequence":"additional","affiliation":[{"name":"National Cancer Center\/National Clinical Research Center for Cancer\/Cancer Hospital Chinese Academy of Medical Sciences and Peking Union Medical College Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhihui","family":"Zhang","sequence":"additional","affiliation":[{"name":"National Cancer Center\/National Clinical Research Center for Cancer\/Cancer Hospital Chinese Academy of Medical Sciences and Peking Union Medical College Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xun","family":"Zhang","sequence":"additional","affiliation":[{"name":"National Cancer Center\/National Clinical Research Center for Cancer\/Cancer Hospital Chinese Academy of Medical Sciences and Peking Union Medical College Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qiong","family":"Liao","sequence":"additional","affiliation":[{"name":"Sichuan Clinical Research Center for Cancer, Sichuan Cancer Hospital &amp; Institute, Sichuan Cancer Center University of Electronic Science and Technology of China Chengdu China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shijun","family":"Jia","sequence":"additional","affiliation":[{"name":"Sichuan Clinical Research Center for Cancer, Sichuan Cancer Hospital &amp; Institute, Sichuan Cancer Center University of Electronic Science and Technology of China Chengdu China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dongsheng","family":"Wang","sequence":"additional","affiliation":[{"name":"Sichuan Clinical Research Center for Cancer, Sichuan Cancer Hospital &amp; Institute, Sichuan Cancer Center University of Electronic Science and Technology of China Chengdu China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lingling","family":"Zhu","sequence":"additional","affiliation":[{"name":"Sichuan Clinical Research Center for Cancer, Sichuan Cancer Hospital &amp; Institute, Sichuan Cancer Center University of Electronic Science and Technology of China Chengdu China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xingsheng","family":"Cai","sequence":"additional","affiliation":[{"name":"GuangDong Engineering Technology Research Center of Multiplex PCR &amp; Tumor Diagnostics (2022A095) Guangzhou China"},{"name":"Mygene Diagnostics Co. Ltd Guangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chunlin","family":"Wang","sequence":"additional","affiliation":[{"name":"GuangDong Engineering Technology Research Center of Multiplex PCR &amp; Tumor Diagnostics (2022A095) Guangzhou China"},{"name":"Mygene Diagnostics Co. Ltd Guangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lingmei","family":"Yan","sequence":"additional","affiliation":[{"name":"GuangDong Engineering Technology Research Center of Multiplex PCR &amp; Tumor Diagnostics (2022A095) Guangzhou China"},{"name":"Mygene Diagnostics Co. Ltd Guangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoyan","family":"Le","sequence":"additional","affiliation":[{"name":"GuangDong Engineering Technology Research Center of Multiplex PCR &amp; Tumor Diagnostics (2022A095) Guangzhou China"},{"name":"Mygene Diagnostics Co. Ltd Guangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hua","family":"Yang","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, National Clinical Research Center for Obstetric &amp; Gynecologic Diseases, State Key Laboratory of Common Mechanism Research for Major Diseases Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Youlin","family":"Qiao","sequence":"additional","affiliation":[{"name":"Center for Global Health, School of Population Medicine and Public Health Chinese Academy of Medical Sciences &amp; Peking Union Medical College Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jennifer S.","family":"Smith","sequence":"additional","affiliation":[{"name":"Department of Epidemiology UNC Gillings School of Global Public Health Chapel Hill USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuqian","family":"Zhao","sequence":"additional","affiliation":[{"name":"Sichuan Clinical Research Center for Cancer, Sichuan Cancer Hospital &amp; Institute, Sichuan Cancer Center University of Electronic Science and Technology of China Chengdu China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lan","family":"Zhu","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, National Clinical Research Center for Obstetric &amp; Gynecologic Diseases, State Key Laboratory of Common Mechanism Research for Major Diseases Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6603-0056","authenticated-orcid":false,"given":"Wen","family":"Chen","sequence":"additional","affiliation":[{"name":"National Cancer Center\/National Clinical Research Center for Cancer\/Cancer Hospital Chinese Academy of Medical Sciences and Peking Union Medical College Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,9,26]]},"reference":[{"key":"e_1_2_13_2_1","unstructured":"Global Burden of 369 Diseases and Injuries in 204 Countries and Territories 1990\u20102019: A Systematic Analysis for the Global Burden of Disease Study 2019.Lancet 2020.396(10258):1204\u20131222."},{"key":"e_1_2_13_3_1","unstructured":"Sexually Transmitted Infections (STIs).2022 https:\/\/www.who.int\/news-room\/fact-sheets\/detail\/sexually-transmitted-infections-(stis)."},{"key":"e_1_2_13_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1473-3099(21)00448-5"},{"key":"e_1_2_13_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/ddg.12310"},{"key":"e_1_2_13_6_1","doi-asserted-by":"publisher","DOI":"10.1093\/cid\/civ312"},{"issue":"1","key":"e_1_2_13_7_1","first-page":"11","article-title":"The Presentation, Diagnosis, and Treatment of Sexually Transmitted Infections","volume":"113","author":"Wagenlehner F. M.","year":"2016","journal-title":"Deutsches \u00c4rzteblatt international"},{"key":"e_1_2_13_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ygyno.2008.07.045"},{"key":"e_1_2_13_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(13)60022-7"},{"key":"e_1_2_13_10_1","doi-asserted-by":"publisher","DOI":"10.1093\/jnci\/djq562"},{"key":"e_1_2_13_11_1","doi-asserted-by":"publisher","DOI":"10.1128\/CMR.16.1.1-17.2003"},{"key":"e_1_2_13_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cmi.2018.04.019"},{"key":"e_1_2_13_13_1","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.27485"},{"key":"e_1_2_13_14_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00038-019-01261-w"},{"key":"e_1_2_13_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijid.2018.06.001"},{"key":"e_1_2_13_16_1","doi-asserted-by":"publisher","DOI":"10.1136\/sextrans-2013-051431"},{"key":"e_1_2_13_17_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0086266"},{"issue":"6","key":"e_1_2_13_18_1","first-page":"4843","article-title":"Determination of Cervicovaginal Microorganisms in Women With Abnormal Cervical Cytology: The Role of Ureaplasma Urealyticum","volume":"26","author":"Lukic A.","year":"2006","journal-title":"Anticancer Research"},{"key":"e_1_2_13_19_1","doi-asserted-by":"publisher","DOI":"10.3390\/cancers12051093"},{"key":"e_1_2_13_20_1","doi-asserted-by":"publisher","DOI":"10.1111\/cmi.13392"},{"key":"e_1_2_13_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.micinf.2009.01.004"},{"key":"e_1_2_13_22_1","doi-asserted-by":"publisher","DOI":"10.7150\/jca.58582"},{"key":"e_1_2_13_23_1","doi-asserted-by":"publisher","DOI":"10.4269\/ajtmh.2012.12-0287"},{"key":"e_1_2_13_24_1","doi-asserted-by":"publisher","DOI":"10.3802\/jgo.2016.27.e49"},{"key":"e_1_2_13_25_1","doi-asserted-by":"publisher","DOI":"10.1093\/jnci\/djq436"},{"key":"e_1_2_13_26_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13027-022-00420-8"},{"key":"e_1_2_13_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1470-2045(09)70096-8"},{"key":"e_1_2_13_28_1","doi-asserted-by":"publisher","DOI":"10.1111\/cmi.13397"},{"key":"e_1_2_13_29_1","doi-asserted-by":"publisher","DOI":"10.7150\/ijms.26523"},{"key":"e_1_2_13_30_1","doi-asserted-by":"publisher","DOI":"10.2478\/v10039-011-0028-9"},{"issue":"6","key":"e_1_2_13_31_1","first-page":"1371","article-title":"Association of Human Papillomavirus, Neisseria Gonorrhoeae and Chlamydia Trachomatis Co\u2010Infections on the Risk of High\u2010Grade Squamous Intraepithelial Cervical Lesion","volume":"6","author":"De Abreu A. L.","year":"2016","journal-title":"American Journal of Cancer Research"},{"key":"e_1_2_13_32_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijid.2013.09.014"},{"key":"e_1_2_13_33_1","doi-asserted-by":"publisher","DOI":"10.1002\/jmv.24278"},{"key":"e_1_2_13_34_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jiac.2013.08.005"},{"key":"e_1_2_13_35_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jmii.2017.05.004"},{"key":"e_1_2_13_36_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12879-021-06966-z"},{"key":"e_1_2_13_37_1","doi-asserted-by":"publisher","DOI":"10.3389\/fcimb.2023.1145215"},{"key":"e_1_2_13_38_1","doi-asserted-by":"publisher","DOI":"10.1128\/JCM.00159-14"},{"key":"e_1_2_13_39_1","doi-asserted-by":"publisher","DOI":"10.1093\/infdis\/jit101"},{"key":"e_1_2_13_40_1","doi-asserted-by":"publisher","DOI":"10.1530\/REP-21-0308"},{"key":"e_1_2_13_41_1","doi-asserted-by":"publisher","DOI":"10.2217\/fmb-2019-0242"},{"key":"e_1_2_13_42_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-019-50410-x"},{"key":"e_1_2_13_43_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms26031296"},{"key":"e_1_2_13_44_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12879-015-1055-0"},{"key":"e_1_2_13_45_1","doi-asserted-by":"publisher","DOI":"10.1002\/ijgo.14763"},{"key":"e_1_2_13_46_1","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2180-9-139"},{"key":"e_1_2_13_47_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.ppat.1008376"},{"key":"e_1_2_13_48_1","doi-asserted-by":"publisher","DOI":"10.1093\/ofid\/ofab206"},{"key":"e_1_2_13_49_1","doi-asserted-by":"publisher","DOI":"10.1097\/MD.0000000000027599"},{"key":"e_1_2_13_50_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2024.1369086"},{"key":"e_1_2_13_51_1","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.32003"},{"key":"e_1_2_13_52_1","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.30032"}],"container-title":["Journal of Medical Virology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/jmv.70616","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/jmv.70616","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/jmv.70616","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,1,31]],"date-time":"2026-01-31T11:08:01Z","timestamp":1769857681000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/jmv.70616"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,9,26]]},"references-count":51,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2025,10]]}},"alternative-id":["10.1002\/jmv.70616"],"URL":"https:\/\/doi.org\/10.1002\/jmv.70616","archive":["Portico"],"relation":{},"ISSN":["0146-6615","1096-9071"],"issn-type":[{"value":"0146-6615","type":"print"},{"value":"1096-9071","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,9,26]]},"assertion":[{"value":"2025-04-15","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-09-11","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-09-26","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e70616"}}