{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,31]],"date-time":"2026-01-31T23:13:29Z","timestamp":1769901209742,"version":"3.49.0"},"reference-count":40,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2025,9,29]],"date-time":"2025-09-29T00:00:00Z","timestamp":1759104000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2025,9,29]],"date-time":"2025-09-29T00:00:00Z","timestamp":1759104000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal of Medical Virology"],"published-print":{"date-parts":[[2025,10]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    Diffuse large B\u2010cell lymphoma (DLBCL) is clinically heterogeneous malignancy with complex etiological factors. The role of Epstein\u2010Barr virus (EBV) infection, particularly infectious mononucleosis (IM), in DLBCL development remains controversial. This study aims to elucidate the potential mechanisms underlying the inverse association between IM and DLBCL by investigating the causal relationship between EBV and DLBCL using Mendelian randomization (MR) and comprehensive miRNA profiling. We employed a two\u2010sample MR approach to assess the causal effect of EBV infection on DLBCL risk, using genetic variants associated with IM and DLBCL from genome\u2010wide association studies (GWAS). miRNA profiling was performed on bulk RNA sequencing data from IM and DLBCL samples. Differential expression analysis, functional enrichment, and protein\u2010protein interaction (PPI) network analysis were conducted to identify key regulatory pathways and potential therapeutic targets. MR analysis demonstrated a potential inverse association between IM and DLBCL, with an odds ratio (OR) of 0.796 (95%CI: 0.635\u20130.999,\n                    <jats:italic>p<\/jats:italic>\n                    \u2010value\u2009=\u20090.049). Differential miRNA expression analysis identified significant dysregulation in 146 miRNAs in IM and 328 miRNAs in DLBCL, with nine shared miRNAs suggesting overlapping regulatory pathways. Functional enrichment highlighted critical pathways such as autophagy and apoptotic signaling. The prognostic model successfully stratified patients into high\u2010 and low\u2010risk groups, significantly correlating with survival outcomes. Drug sensitivity analysis indicated increased responsiveness to targeted therapies in high\u2010risk patients. These findings suggest biological mechanisms that may underlie the observed inverse association between IM and DLBCL and provide candidate miRNAs for prognostic evaluation. Further validation in larger, multi\u2010ethnic cohorts with molecular subtyping is needed.\n                  <\/jats:p>","DOI":"10.1002\/jmv.70621","type":"journal-article","created":{"date-parts":[[2025,9,29]],"date-time":"2025-09-29T10:54:07Z","timestamp":1759143247000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Exploring the Potential Association of Infectious Mononucleosis With Diffuse Large B\u2010Cell Lymphoma: A Mendelian Randomization and miRNA Profiling Approach"],"prefix":"10.1002","volume":"97","author":[{"given":"Weimin","family":"Huang","sequence":"first","affiliation":[{"name":"Department of Hematology, Guangzhou Eighth People's Hospital Guangzhou Medical University Guangzhou China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jing","family":"Ai","sequence":"additional","affiliation":[{"name":"Department of Hematology, Guangzhou Eighth People's Hospital Guangzhou Medical University Guangzhou China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lanlan","family":"Jia","sequence":"additional","affiliation":[{"name":"Department of Hematology, Guangzhou Eighth People's Hospital Guangzhou Medical University Guangzhou China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jinying","family":"Gan","sequence":"additional","affiliation":[{"name":"Department of Hematology, Guangzhou Eighth People's Hospital Guangzhou Medical University Guangzhou China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Junteng","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Hematology, Guangzhou Eighth People's Hospital Guangzhou Medical University Guangzhou China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Manwen","family":"Tian","sequence":"additional","affiliation":[{"name":"Department of Hematology, Guangzhou Eighth People's Hospital Guangzhou Medical University Guangzhou China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lingzhen","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Hematology, Guangzhou Eighth People's Hospital Guangzhou Medical University Guangzhou China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0005-0949-0354","authenticated-orcid":false,"given":"Yongmin","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Hematology, Guangzhou Eighth People's Hospital Guangzhou Medical University Guangzhou China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2025,9,29]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMra2027612"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajh.26151"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00432-021-03824-y"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1080\/2162402X.2019.1683346"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0201546"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1080\/09674845.2021.1903683"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20161846"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.3389\/fonc.2019.00109"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1080\/01635581.2024.2399868"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-025-91594-9"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1038\/s43586-021-00092-5"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1007\/s40471-017-0128-6"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1093\/hmg\/ddu328"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1007\/s13105-010-0050-6"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopha.2020.110986"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.1002\/hon.2956"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jbc.2024.105762"},{"key":"e_1_2_9_19_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2023.1322806"},{"issue":"10","key":"e_1_2_9_20_1","article-title":"Bioinformatics in Early Cancer Detection","volume":"15","author":"Nelakurthi V. 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