{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,31]],"date-time":"2026-01-31T21:54:40Z","timestamp":1769896480993,"version":"3.49.0"},"reference-count":36,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2025,10,1]],"date-time":"2025-10-01T00:00:00Z","timestamp":1759276800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2025,10,1]],"date-time":"2025-10-01T00:00:00Z","timestamp":1759276800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal of Medical Virology"],"published-print":{"date-parts":[[2025,10]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    The infection with human papillomavirus (HPV), particularly the persistent infection with high\u2010risk HPV, is closely associated with the development of cervical cancer. A total of 81,397 specimens of cervical epithelium were collected in Weifang City from 2012 to 2023. The participants were divided into five age groups and tested for 23 HPV subtypes (13 high\u2010risk and 10 low\u2010risk subtypes) using a commercial kit. The overall infection rate of HPV was 23.78%, with the infection rate of high\u2010risk HPV being 18.36%. The top five most prevalent subtypes were HPV16, 52, 58, 51, and 68. The infection rate of low\u2010risk HPV was 5.42%, with the most common subtypes being HPV53, 81, and 66. Among different age groups, people aged 18\u201324 years and those aged \u2265\u200955 years exhibited higher infection rates, which were 33.55% and 26.29%, respectively. The predominant type of infection was single infection, followed by double infection. Joinpoint regression analysis revealed that the infection rates of HPV and HR\u2010HPV exhibited a downward trend over time (\n                    <jats:italic>p<\/jats:italic>\n                    \u2009&lt;\u20090.05), with a significant turning point identified. Bayesian structural time series model (BSTS model) suggests that human papillomavirus vaccination may have prevented 1,705 cases of infection between 2018 and 2023, equating to a 14.5% reduction in infection rates. This study reveals the characteristics of the age distribution of HPV infection rates and genotypic infections in the region, suggests that HPV vaccination may influence the trend of HPV infection, and provides an epidemiological basis for disease prevention in the region.\n                  <\/jats:p>","DOI":"10.1002\/jmv.70624","type":"journal-article","created":{"date-parts":[[2025,10,1]],"date-time":"2025-10-01T10:37:12Z","timestamp":1759315032000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Trend Analysis of HPV Prevalence in Weifang City Using a\u00a0Bayesian Structural Time Series Model: A Longitudinal Study From 2012 to 2023"],"prefix":"10.1002","volume":"97","author":[{"ORCID":"https:\/\/orcid.org\/0009-0009-3994-0466","authenticated-orcid":false,"given":"Haoran","family":"Yang","sequence":"first","affiliation":[{"name":"School of Nursing Shandong Second Medical University Weifang Shandong Province People's Republic of China"},{"name":"School of Public Health Shandong Second Medical University Weifang Shandong Province People's Republic of China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jian","family":"Xu","sequence":"additional","affiliation":[{"name":"Weifang Maternal and Child Health Hospital Weifang Shandong Province People's Republic of China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hongwei","family":"Wang","sequence":"additional","affiliation":[{"name":"Anqiu Centre for Disease Control and Prevention Weifang Shandong Province People's Republic of China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hong","family":"Kou","sequence":"additional","affiliation":[{"name":"School of Nursing Shandong Second Medical University Weifang Shandong Province People's Republic of China"},{"name":"School of Public Health Shandong Second Medical University Weifang Shandong Province People's Republic of China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiao","family":"Yang","sequence":"additional","affiliation":[{"name":"School of Nursing Shandong Second Medical University Weifang Shandong Province People's Republic of China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jing","family":"Li","sequence":"additional","affiliation":[{"name":"School of Public Health Shandong Second Medical University Weifang Shandong Province People's Republic of China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2025,10]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.virol.2013.05.012"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1590\/S0365-05962011000200014"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(98)12490-X"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41579-021-00617-5"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.3389\/fpubh.2020.552028"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jinf.2018.02.008"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.30035"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1080\/21645515.2024.2329450"},{"key":"e_1_2_10_10_1","unstructured":"Hainan girls of appropriate age receive free HPV vaccine.China News Network;2022. Mar 12 [accessed 2025 Aug] https:\/\/baijiahao.baidu.com\/s?id=1727072112419925717&wfr=spider&for=pc."},{"key":"e_1_2_10_11_1","unstructured":"Fujian Province launches free HPV vaccination program for women of appropriate age.Fujian Provincial Health Commission;2022. May 12 [accessed 2025 Aug] https:\/\/wjw.fujian.gov.cn\/jggk\/csxx\/fyjkfwc\/fyggws\/202205\/t20220512_5909168.htm."},{"key":"e_1_2_10_12_1","unstructured":"The first domestic nine\u2010valent HPV vaccine jointly developed by Xiamen University and Wantai Biologicals is approved for marketing\u2010Xiamen University News.;2025.June 4 [accessed 2025 Aug] https:\/\/news.xmu.edu.cn\/info\/1002\/499302.htm."},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1473-3099(23)00275-X"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0304760"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-021-96131-y"},{"key":"e_1_2_10_16_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0230640"},{"key":"e_1_2_10_17_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12889-017-4651-7"},{"key":"e_1_2_10_18_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12879-024-10011-0"},{"key":"e_1_2_10_19_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-025-89759-7"},{"key":"e_1_2_10_20_1","doi-asserted-by":"publisher","DOI":"10.1002\/jmv.27453"},{"key":"e_1_2_10_21_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41417-023-00682-3"},{"key":"e_1_2_10_22_1","doi-asserted-by":"publisher","DOI":"10.7326\/M21-3798"},{"key":"e_1_2_10_23_1","doi-asserted-by":"publisher","DOI":"10.1086\/657321"},{"key":"e_1_2_10_24_1","doi-asserted-by":"publisher","DOI":"10.3390\/vaccines12111262"},{"key":"e_1_2_10_25_1","doi-asserted-by":"publisher","DOI":"10.3389\/fmicb.2022.985561"},{"key":"e_1_2_10_26_1","doi-asserted-by":"publisher","DOI":"10.1128\/CMR.16.1.1-17.2003"},{"key":"e_1_2_10_27_1","doi-asserted-by":"publisher","DOI":"10.1080\/07853890.2024.2404548"},{"key":"e_1_2_10_28_1","doi-asserted-by":"publisher","DOI":"10.1089\/jwh.2008.1223"},{"key":"e_1_2_10_29_1","doi-asserted-by":"publisher","DOI":"10.1128\/JCM.00087-13"},{"key":"e_1_2_10_30_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0304-3835(03)00312-4"},{"key":"e_1_2_10_31_1","doi-asserted-by":"publisher","DOI":"10.1097\/LGT.0000000000000487"},{"key":"e_1_2_10_32_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12885-018-4330-9"},{"key":"e_1_2_10_33_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tjog.2022.07.007"},{"key":"e_1_2_10_34_1","doi-asserted-by":"publisher","DOI":"10.1071\/SH24057"},{"issue":"8","key":"e_1_2_10_35_1","article-title":"Cytology Versus HPV Testing for Cervical Cancer Screening in the General Population","volume":"8","author":"Koliopoulos G.","year":"2017","journal-title":"Cochrane Database of Systematic Reviews"},{"key":"e_1_2_10_36_1","doi-asserted-by":"publisher","DOI":"10.3390\/medicina58121697"},{"key":"e_1_2_10_37_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12905-025-03841-w"}],"container-title":["Journal of Medical Virology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/jmv.70624","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/jmv.70624","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/jmv.70624","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,1,31]],"date-time":"2026-01-31T11:07:09Z","timestamp":1769857629000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/jmv.70624"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,10]]},"references-count":36,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2025,10]]}},"alternative-id":["10.1002\/jmv.70624"],"URL":"https:\/\/doi.org\/10.1002\/jmv.70624","archive":["Portico"],"relation":{},"ISSN":["0146-6615","1096-9071"],"issn-type":[{"value":"0146-6615","type":"print"},{"value":"1096-9071","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,10]]},"assertion":[{"value":"2025-06-21","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-09-20","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-10-01","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e70624"}}